A5068441646- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Cellular Mechanics and Interactions
- Nuclear Structure and Function
- Biotin and Related Studies
- Bone Tissue Engineering Materials
- Venous Thromboembolism Diagnosis and Management
- Exercise and Physiological Responses
- Hippo pathway signaling and YAP/TAZ
- thermodynamics and calorimetric analyses
- Cellular transport and secretion
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Orthopedic Infections and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Neurogenesis and neuroplasticity mechanisms
- Protease and Inhibitor Mechanisms
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
2015-2025
Polish Academy of Sciences
2015-2025
New York Academy of Sciences
2018
John Wiley & Sons (United States)
2018
Hudson Institute
2018
University of Warsaw
2017
ABSTRACT Neuromuscular junctions (NMJs), the synapses made by motor neurons on muscle fibers, form during embryonic development but undergo substantial remodeling postnatally. Several lines of evidence suggest that α-dystrobrevin, a component dystrophin-associated glycoprotein complex (DGC), is crucial regulator process and tyrosine phosphorylation one isoform, α-dystrobrevin-1, required for its function at synapses. We identified functionally important site generated...
Abstract Neuromuscular junctions (NMJs) are specialized synapses that connect motor neurons to skeletal muscle fibers and orchestrate proper signal transmission from the nervous system muscles. The efficient formation maintenance of postsynaptic machinery contains acetylcholine receptors (AChR) indispensable for NMJ function. Abnormalities in organization synaptic components often cause severe neuromuscular disorders, such as muscular dystrophy. dystrophin-associated glycoprotein complex...
The neuromuscular junctions (NMJs) connect muscle fibers with motor neurons and enable the coordinated contraction of skeletal muscles. dystrophin-associated glycoprotein complex (DGC) is an essential component postsynaptic machinery NMJ important for maintenance structural integrity. To identify novel proteins that are organization, we performed a mass spectrometry-based screen interactors α-dystrobrevin 1, one components DGC. guanidine nucleotide exchange factor Arhgef5 was found to be 1...
Skeletal muscle growth and regeneration relies on the activation of specific stem cells, that is, satellite cells. The differentiation cells into myoblasts, as well their migration, proliferation, fusion mononuclear myoblasts a functional multi-nucleated fiber, are associated with extracellular matrix (ECM) protein synthesis degradation. environment is dynamically adapting to changes accompanying skeletal or repair. Enzymes engaged in many biological processes involve ECM remodeling...
Proper muscle function depends on the neuromuscular junctions (NMJs), which mature postnatally to complex “pretzel-like” structures, allowing for effective synaptic transmission. Postsynaptic acetylcholine receptors (AChRs) at NMJs are anchored in actin cytoskeleton and clustered by scaffold protein rapsyn, recruiting various actin-organizing proteins. Mechanisms driving maturation of postsynaptic machinery regulating rapsyn interactions with still poorly understood. Drebrin is an...
Abstract The molecular mechanisms underlying the development and maintenance of neuromuscular junction are poorly understood, even though malfunction these specialized synapses is associated with severe genetic autoimmune disorders. identity factors controlling postsynaptic acetylcholine receptors (AChR) in high-density has been elusive great interest to pharma industry, searching for possible new targets disease interventions. Here, we report identification a scaffold protein SH3BP2, which...