A5102968376- Genetics, Aging, and Longevity in Model Organisms
- Frailty in Older Adults
- Epigenetics and DNA Methylation
- Nutrition and Health in Aging
- Mechanical stress and fatigue analysis
- Mitochondrial Function and Pathology
- Fungal and yeast genetics research
- Diet and metabolism studies
- Insurance, Mortality, Demography, Risk Management
- Adhesion, Friction, and Surface Interactions
- Gut microbiota and health
- Ginseng Biological Effects and Applications
- Dementia and Cognitive Impairment Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Advanced Chemical Physics Studies
- DNA Repair Mechanisms
- Identity, Memory, and Therapy
- Plant Gene Expression Analysis
- Genomics and Chromatin Dynamics
- Chronic Myeloid Leukemia Treatments
- Health disparities and outcomes
- Pharmacological Effects of Natural Compounds
- Aging and Gerontology Research
- Birth, Development, and Health
- Dietary Effects on Health
Tulane University
2013-2024
MSD (South Korea)
2024
Korean Society of Ginseng
2022-2023
Yonsei University
2006-2021
Peter MacCallum Cancer Centre
2013-2018
The University of Melbourne
2018
Kyungpook National University
2016
Seoul National University
2012
Louisiana State University Health Sciences Center New Orleans
2003-2007
Osaka City University
2007
The human gastrointestinal microbiota plays a key homeostatic role in normal functioning of physiologic processes commonly undermined by aging. We used previously validated 34-item frailty index (FI34) to identify changes gut community structure associated with biological age community-dwelling adults. Stool 16S rRNA cDNA libraries from 85 subjects ranging (43-79) and FI34 score (0-0.365) were deep sequenced, denoised, clustered using DADA2. Subject but not chronological correlated decrease...
Abstract Replicative capacity, which is the number of times an individual cell divides, measure longevity in yeast Saccharomyces cerevisiae. In this study, a process that involves signaling from mitochondrion to nucleus, called retrograde regulation, shown determine longevity, and its induction resulted postponed senescence. Activation by genetic environmental means, correlated with increased replicative capacity four different S. cerevisiae strains. Deletion gene required for response,...
The yeast Saccharomyces cerevisiae has a limited life-span, which is measured by the number of divisions that individual cells complete. Among many changes occur as yeasts age are alterations in chromatin-dependent transcriptional silencing. We have genetically manipulated histone deacetylases to modify chromatin, and we examined effect on longevity. Deletion deacetylase gene RPD3 extended life-span. Its effects chromatin functional state were evidenced enhanced silencing at three known...
To design rational therapies for JAK2-driven hematological malignancies, we functionally dissected the key survival pathways downstream of hyperactive JAK2. In tumors driven by mutant JAK2, Stat1, Stat3, Stat5, and Pi3k Mek/Erk were constitutively active, gene expression profiling TEL-JAK2 T-ALL cells revealed upregulation prosurvival Bcl-2 family genes. Combining Bcl-2/Bcl-xL inhibitor ABT-737 with JAK2 inhibitors mediated prolonged disease regressions cures in mice bearing primary human...
The measurement of biological age as opposed to chronological is important allow the study factors that are responsible for heterogeneity in decline health and function ability among individuals during aging. Various measures aging have been proposed. Frailty indices based on deficits diverse body systems well studied, we documented use a frailty index (FI34) composed 34 items, measuring age. A different approach leukocyte DNA methylation. It has termed methylation age, derivatives this...
Numerous genetic and non-genetic factors contribute to aging. To facilitate the study of these factors, various descriptors biological aging, including 'successful aging' 'frailty', have been put forth as integrative functional measures A separate but related quantitative approach is 'frailty index', which has operationalized frequently used. Various frailty indices constructed. Although based on different numbers types health variables, possess several common properties that make them...
Abstract Sphingolipid metabolites in mammals can function as signaling molecules with cell-specific functions. In Saccharomyces cerevisiae, phosphorylated long chain bases, such dihydrosphingosine 1-phosphate and phytosphingosine 1-phosphate, have also been implicated stress responses. To further explore the biological roles of these molecules, we created disruption mutants for LCB4, LCB5, DPL1, YSR2, YSR3, SUR2. LCB4 LCB5 encode kinases that phosphorylate bases. DPL1 YSR2/YSR3 are involved...
A reliable model of biological age is instrumental in the field geriatrics and gerontology. This should account for heterogeneity plasticity aging also accurately predict aging-related adverse outcomes. Epigenetic models are based on DNA methylation levels at selected genomic sites can be significant predictors mortality healthy/unhealthy aging. However, function yet to determined. Frailty a syndrome resulting from decreased physiological reserves resilience. The frailty index...
The hallmarks of aging have contributed immensely to the systematization research on and emergence geroscience. developments that led concepts geroscience were first marked by proliferation 'theories' aging, mostly based experimental predilections practitioners research. Deeper consideration leads quandary whether a biological process exists beyond disease itself. To address this difficulty, metric age as opposed calendar is necessary. Several examples measured using similar assumptions, but...
Summary The search for longevity‐determining genes in human has largely neglected the operation of genetic interactions. We have identified a novel combination common variants three that marked association with lifespan and healthy aging. Subjects were recruited stratified according to their genetically inferred ethnic affiliation account population structure. Haplotype analysis was performed candidate genes, haplotype combinations tested exceptional longevity. An HRAS1 enhanced effect an...
We investigated the potential probiotic properties of Limosilactobacillus fermentum KGC1601 isolated from Panax ginseng. Ginseng cultivated in an experimental field Korea Research Institute was fermented, followed by single colony selection MRS agar. performed 16s-rRNA sequencing and whole-genome analysis to identify L. evaluate biosafety parameters this strain, respectively. confirmed strain susceptible six antibiotics, as proposed European Food Safety Authority, did not produce biogenic...
Biological age is a concept that takes into account the heterogeneity of aging process in different individuals results differences survival and variations relative health. Any measure biological must be better than chronological at predicting mortality. Several quantitative measures have been developed. Among them are frailty indices, one which called FI34 discussed here greater detail. increases exponentially with reflecting decline health function ability. It readily depicts patterns...
Activating JAK2 point mutations are implicated in the pathogenesis of myeloid and lymphoid malignancies, including high-risk B-cell acute lymphoblastic leukemia (B-ALL). In preclinical studies, treatment mutant leukemias with type I inhibitors (e.g., Food Drug Administration [FDA]-approved ruxolitinib) provided limited single-agent responses, possibly due to paradoxical Y1007/1008 hyperphosphorylation induced by these agents. To determine importance B-ALL initiation maintenance, we developed...
Social behaviors are associated with health outcomes in later life. The authors examined relationships among social and physical activities a lifespan sample of adults (N = 771) drawn from the Louisiana Healthy Aging Study (LHAS). Four age groups were compared: younger (21-44 years), middle-aged (45-64 older (65-84 oldest-old (85 to 101 years). Linear regression analyses indicated that activity, hours spent outside house, support significantly self-reported health, after controlling for...