A5061311036- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Animal Nutrition and Physiology
- Animal Behavior and Welfare Studies
- Brucella: diagnosis, epidemiology, treatment
- Bacteriophages and microbial interactions
- Antibiotic Resistance in Bacteria
- Galectins and Cancer Biology
- Antibiotics Pharmacokinetics and Efficacy
- Escherichia coli research studies
- Genomics and Phylogenetic Studies
- Meat and Animal Product Quality
- Chromosomal and Genetic Variations
- Microbial Fuel Cells and Bioremediation
- Genetic diversity and population structure
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Genetics and Plant Breeding
- Membrane-based Ion Separation Techniques
- Monoclonal and Polyclonal Antibodies Research
- Ion Transport and Channel Regulation
- 14-3-3 protein interactions
- Sphingolipid Metabolism and Signaling
- Genomics and Rare Diseases
- Urban Stormwater Management Solutions
Fundación INTRAS
2020
Instituto de Biomedicina y Biotecnología de Cantabria
2009-2014
Universidad de Cantabria
2000-2012
Consejo Superior de Investigaciones Científicas
2012
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
2010-2011
Marqués de Valdecilla University Hospital
2008-2011
Fundación Marques de Valdecilla
2011
Centro de Investigación y Desarrollo
2008
Samueli Institute
2006
University of California, Irvine
2006
Protein phosphorylation by protein kinases may generate docking sites for other proteins. It thus allows the assembly of signaling complexes in response to kinase activation. Several domains that bind phosphoserine or phosphothreonine residues have been identified, including 14-3-3, PIN1, FHA, KIX, WD-40 domain, and polo box (Yaffe, M. B., Elia, A. E. (2001) Curr. Opin. Cell Biol. 13, 131-138; E., Cantley, L. C., Yaffe, B. (2003) Science 299, 1228-1231). The BRCA1 COOH-terminal (BRCT) are...
Summary Multilocus homozygosity, measured as the proportion of autosomal genome in homozygous genotypes or runs was compared with respective pedigree inbreeding coefficients 64 Iberian pigs genotyped using Porcine SNP 60 Beadchip. Pigs were sampled from a set experimental animals large variation born closed strain completely recorded multi‐generation genealogy. Individual calculated strongly correlated different ‐derived metrics homozygosity ( r = 0.814–0.919). However, unequal correlations...
Summary Nucleotide sequences of mitochondrial DNA (mtDNA) cytochrome B gene (1140 bp) and control region (707 were used to determine the phylogenetic relationships among 51 pig samples representing ancient current varieties Iberian pigs (26), Spanish wild boars (seven) other domestic (18) cosmopolitan (Duroc, Large White, Landrace, Pietrain Meishan) local (Spotted Black Jabugo, Basque Mangalitza) breeds. A neighbour‐joining tree constructed from pairwise distances provide evidence European...
Most members of the genus Brucella show strong urease activity. However, role this enzyme in pathogenesis infections is poorly understood. We isolated several Tn5 insertion mutants deficient activity from abortus strain 2308. The mutations most these mapped to a 5.7-kbp DNA region essential for Sequencing region, designated ure1, revealed presence seven open reading frames corresponding structural proteins (UreA, UreB, and UreC) accessory (UreD, UreE, UreF, UreG). In addition genes, another...
Background The two-component BvrR/BvrS system is essential for Brucella abortus virulence. It was shown previously that its dysfunction alters the expression of some major outer membrane proteins and pattern lipid A acylation. To determine genes regulated by BvrR/BvrS, we performed a whole-genome microarray analysis using B. RNA obtained from wild type bvrR mutant cells grown in same conditions. Methodology/Principal Findings total 127 differentially expressed were found: 83 over 44 less...
ABSTRACT There is limited information on the role of penicillin-binding proteins (PBPs) in resistance Acinetobacter baumannii to β-lactams. This study presents an analysis allelic variations PBP genes A. isolates. Twenty-six clinical isolates (susceptible or resistant carbapenems) from three teaching hospitals Spain were included. The antimicrobial susceptibility profile, clonal pattern, and genomic species identification also evaluated. Based six complete genomes , identified, primers...
In contrast to international pig breeds, the Iberian breed has not been admixed with Asian germplasm. This makes it an important model study both domestication and relevance of genes in pig. Besides, pigs exhibit high meat quality as well appetite propensity obesity. Here we provide a genome wide analysis nucleotide structural diversity reduced representation library from pool (n=9 sows) shotgun genomic sequence single sow highly inbred Guadyerbas strain. pool, applied newly developed tools...
Abstract An experimental herd of Large White pigs was established in 1931 and maintained as a closed population until 1992. The complete -pedigree (410 boars 916 sows) has been analysed to measure along the succesive cohorts breeding animals: thefounder representation allele survival, evolution ofcoancestry inbreeding components due each founder. Inferences about genetic phenotypic parameters effects dam litter on size were obtained, using Bayesian techniques, from 2612 records. A...
Genetic progress for reproductive performance in pigs is limited by mothering ability. It a critical aspect dam lines, which litter weight at weaning could be included with size the selection goal. Our objective was to investigate Iberian genetic basis of number alive born piglets (NBA) and 21days (LW21) over successive parities (t). Records NBA were available from 6,775 litters 1,893 sows Torbiscal line, LW21 records proceeded 1,431 2,963 without crossfostering. parameters estimated using...
Bacteria of the genus Brucella have unusual capability to catabolize erythritol and this property has been associated with their virulence mainly because presence in bovine foetal tissues attenuated S19 vaccine strain is only unable oxydize erythritol. In work we analyzed transcriptional changes produced by means two high throughput approaches: RNA hybridization against a microarray containing most ORF's constructed from ORFeome next generation sequencing mRNA an Illumina GAIIx platform. The...
Summary The complete pedigree of two closed Iberian pig lines ( Gamito and Torbiscal ), with 798 4077 reproducers, has been used to measure the evolution coancestry f ) inbreeding F for autosomal X‐linked genes along 16 28 respective equivalent discrete generations. At last generation, mean values each line were = 0.41 0.22, 0.35 0.18, X 0.46 0.22 0.47 0.19, respectively. Other calculated parameters effective number founders (final values, 6.8 35.2) non‐founders (1.5 2.4), founder genome...
Summary We carried out a comprehensive genomic analysis of porcine copy number variants ( CNV s) based on whole‐genome SNP genotyping data and provided new measures diversity (number, length distribution events) for highly inbred strain (the Guadyerbas strain). This represents one the most ancient surviving populations Iberian breed, it is currently in serious danger extinction. detection was conducted complete population, adjusted waves, used strict quality criteria, pedigree information...
The time since the divergence of European and East Asian domestic pigs wild boars has been estimated in several phylogenetic analyses, generally based on partial mitochondrial sequences or a small number complete mtDNA sequences. In present study, we obtained refined estimate this set 32 near-complete from types, including 14 new 18 previously published A weighted average for different functional components resulted an 746 000 YBP Asian-type European-type pigs. addition, our data allowed us...
The growth performance of inbred pigs coming from full-sib matings was compared to that contemporary animals the same sires mated control dams. belong three strains Iberian with different histories previous inbreeding. data consisted 1,615 weight records between 50 and 250 d age 229 pigs. statistical model assumed two parameters describe linear function (a = intercept, b slope) as traits (weight at 120 daily gain) analysis carried out in a Bayesian framework via Gibbs sampling. means...