A5057672096- Metabolomics and Mass Spectrometry Studies
- Genetic Associations and Epidemiology
- Lipid Membrane Structure and Behavior
- Bioinformatics and Genomic Networks
- Protein Structure and Dynamics
- Click Chemistry and Applications
- Oral and gingival health research
- Bacterial Genetics and Biotechnology
- Metabolism and Genetic Disorders
- Cancer-related gene regulation
- RNA modifications and cancer
- Biochemical and Molecular Research
- Enzyme Structure and Function
Gwangju Institute of Science and Technology
2021-2024
Abstract Phosphatidylethanolamine (PE), a major component of the cellular membrane across all domains life, is synthesized exclusively by membrane-anchored phosphatidylserine decarboxylase (PSD) in most bacteria. The enzyme undergoes auto-cleavage for activation and utilizes pyruvoyl moiety to form Schiff base intermediate with PS facilitate decarboxylation. However, structural basis self-maturation, binding, decarboxylation processes directed PSD remain unclear. Here, we present X-ray...
Abstract Most heritable diseases are polygenic. To comprehend the underlying genetic architecture, it is crucial to discover clinically relevant epistatic interactions (EIs) between genomic single nucleotide polymorphisms (SNPs) (1–3). Existing statistical computational methods for EI detection mostly limited pairs of SNPs due combinatorial explosion higher-order EIs. With NeEDL (network-based epistasis via local search), we leverage network medicine inform selection EIs that an order...
Abstract The uridine at the 34th position of tRNA, which is able to base pair with 3′-end codon on mRNA, usually modified influence many aspects decoding properties during translation. Derivatives 5-methyluridine (xm5U), include methylaminomethyl (mnm-) or carboxymethylaminomethyl (cmnm-) groups C5 uracil base, are widely conserved prokaryotic tRNAs. In Gram-negative bacteria such as Escherichia coli, a bifunctional MnmC involved in last two reactions biosynthesis mnm5(s2)U, enzyme first...
Phosphatidylserine synthase (PssA) is essential in the biosynthesis of phosphatidylethanolamine, a major phospholipid bacterial membranes. A peripheral membrane protein PssA can associate with cellular its active state or exist cytosol an inactive form. The membrane-bound enzyme acts on cytidine diphosphate diacylglycerol (CDP-DG) to form monophosphate and covalent intermediate, which subsequently targeted by serine produce phosphatidylserine. Here, we present two crystal structures...
Abstract Most heritable diseases are polygenic. To comprehend the underlying genetic architecture, it is crucial to discover clinically relevant epistatic interactions (EIs) between genomic single nucleotide polymorphisms (SNPs) 1–3 . Existing statistical computational methods for EI detection mostly limited pairs of SNPs due combinatorial explosion higher-order EIs. With NeEDL ( ne twork-based e pistasis d etection via l ocal search), we leverage network medicine inform selection EIs that...