A5044373568- Cancer Cells and Metastasis
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Glioma Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Single-cell and spatial transcriptomics
- Traumatic Brain Injury and Neurovascular Disturbances
- Management of metastatic bone disease
- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Brain Metastases and Treatment
- Spinal Fractures and Fixation Techniques
- Cancer Research and Treatments
- Neurosurgical Procedures and Complications
- Neurofibromatosis and Schwannoma Cases
- MicroRNA in disease regulation
- Zebrafish Biomedical Research Applications
- 3D Printing in Biomedical Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Bone Tumor Diagnosis and Treatments
- Trauma and Emergency Care Studies
- Pituitary Gland Disorders and Treatments
- Cell Image Analysis Techniques
Western University
2020-2024
University of Windsor
2021-2023
Windsor Regional Hospital
2020-2021
Oxford University Press (United Kingdom)
2020
University of Toronto
2001
✓ Stereotactic radiosurgery is being increasingly advocated as the primary modality for treatment of vestibular schwannomas (VS). This has been shown to arrest tumor growth, with few associated short-term morbidities, and possibly better hearing facial nerve preservation rates than microsurgery. Radiation-induced oncogenesis long recognized, although stereotactic de novo induction a secondary never clearly described. The authors report on patient VS who did not have neurofibromatosis Type 2...
INTRODUCTION: The extremely poor response to therapy, resulting in relapse of patients with GBM, is attributed the existence Glioma Stem Cells (GSCs) and their ability resist standard care therapy. Spy1 a cyclin like protein which plays role expansion GSCs unlike classical cyclins can stimulate cell cycle progression against checkpoint control. METHODS: Twelve GBM patient-derived tumour samples were subjected extraction. cultured as neurospheres enrich for GSC populations vitro. levels...
Glioblastoma is one of the most aggressive types cancer with success therapy being hampered by existence treatment resistant populations stem-like Tumour Initiating Cells (TICs) and poor blood-brain barrier drug penetration. Therapies capable effectively targeting TIC population are in high demand. Here, we synthesize spherical diketopyrrolopyrrole-based Conjugated Polymer Nanoparticles (CPNs) an average diameter 109 nm. CPNs were designed to include fluorescein-conjugated Hyaluronic Acid...
There is a paucity of data on outcomes following four-level anterior cervical discectomy and fusions (ACDFs), especially the sagittal balance (SB) parameters.We aimed to review long-term clinical radiographic for 41 consecutive patients that underwent instrumented ACDF.Records 27 men 14 women, aged 40-68 years, who ACDF plating at C3-C7 (n = 37) or C4-T1 4) were retrospectively analyzed. Clinical assessed visual analog scale (VAS) pain, neck disability index (NDI), Odom's criteria,...
Spontaneous intracranial hypotension (SIH) is a rare condition that can be very debilitating. SIH well understood to due CSF leak, however, identifying the source of leak still challenge. We are presenting case Type 4 and reviewing related literature. A 46-year-old female with intractable orthostatic headaches was diagnosed SIH. She unable mobilize severity her symptoms. MRI scans brain spine did not identify leak. After failing conservative therapy multiple epidural blood patches, patient...
Summary Successful containment of unwanted cell cycle progression in tumours such as glioblastoma (GBM) requires targeted therapeutic approaches which rely on understanding dynamics response to microenvironmental stimuli. Glioma Stem Cells (GSCs) can drive tumour initiation, recurrence, therapy resistance, and are often attributed the heterogeneity plasticity GBM. In vitro models using patient-derived GSCs provide a life relevant tool for exploration complex molecular mechanisms underlying...
Summary Glioblastoma is an aggressive brain tumour associated with high post-therapy recurrence and very poor survival rates. One of the factors contributing to nature this disease level heterogeneity seen at phenotypic genetic level. Glioma Stem Cells (GSCs) are stem-like cells within ability self-renew give rise different types tumour, hence giving found in glioblastoma. GSCs often implicated resistance glioma standard care radiation chemotherapy. The physical niche a mass supports...
INTRODUCTION: The extremely poor response to therapy, resulting in relapse of patients with GBM, is attributed the existence Cancer Stem Cells (CSCs). Lately we have come understanding that regulation CSCs comes also from tumour microenvironment (TME), making attempts therapeutically target solely, largely ineffective. METHODS: Using Fluorescent Activated Cell Sorting (FACS) six individual patient-derived GBM samples, obtained fraction CAFs based on their FAP+/COL1A1+/CD90+/CD31-/EPCAM-...
El-Ghandour, Nasser M.F MD; Elsebaie, Eman; Salem, Amany; Alkhamees, Abdullah; Zaazoue, Mohamed; Fouda, Mohammed A Ahmed, Rasha G. Elbadry; Aly, Bakr, Hebatalla; Labib, Tobin, Matthew K; Gragnaniello, Cristian; Gonzalez-Lo, Pablo; Shamisa, Abdalla MBBS; Jhawar, Balraj S Soliman, Mohamed A.R MD, MSc, PhD Author Information
Glioblastoma is one of the most aggressive types cancer with median survival only 15 months. Successful therapy hampered by existence treatment resistant populations stem-like tumour initiating cells (TICs) and poor blood-brain barrier drug penetration. Therapies capable effectively targeting TIC population are in high demand. Here, we synthesize spherical diketopyrrolopyrrole (DPP)-based conjugated polymer nanoparticles (CPNs) an average diameter 109 nm. The CPN were designed to include...
Glioblastoma is one of the most aggressive types cancer with median survival only 15 months. Successful therapy hampered by existence treatment resistant populations stem-like tumour initiating cells (TICs) and poor blood-brain barrier drug penetration. Therapies capable effectively targeting TIC population are in high demand. Here, we synthesize spherical diketopyrrolopyrrole (DPP)-based conjugated polymer nanoparticles (CPNs) an average diameter 109 nm. The CPN were designed to include...
Abstract The aggressive biology and poor response to therapy resulting in relapse of patients with GBM is attributed the existence Brain Tumour Initiating Cells (BTICs) stem cell properties. Targeting BTICs isolation their surrounding tumour microenvironment (TME) has proven ineffective. Determining molecular effects TME on an evolving area that requires more focus. OUR APPROACH: Using innovative patient-derived organoid co-culture models paired vivo zebrafish xenograft system our...
Lubanska, Dorota; Soliman, Mohamed A.R MD, MS, PhD; Shamisa, Abdalla; DeCarvalho, Ana Rodzinka, Alex; Nyayachavadi, Adit; Rondeau-Gagné, Simon; Kulkarni, Swati; Porter, Lisa Author Information
Glioblastoma is one of the most aggressive types cancer with median survival only 15 months. Successful therapy hampered by existence treatment resistant populations stem-like tumour initiating cells (TICs) and poor blood-brain barrier drug penetration. Therapies capable effectively targeting TIC population are in high demand. Here, we synthesize spherical diketopyrrolopyrrole (DPP)-based conjugated polymer nanoparticles (CPNs) an average diameter 109 nm. The CPN were designed to include...
Glioblastoma is one of the most aggressive types cancer with median survival only 15 months. Successful therapy hampered by existence treatment resistant populations stem-like tumour initiating cells (TICs) and poor blood-brain barrier drug penetration. Therapies capable effectively targeting TIC population are in high demand. Here, we synthesize spherical diketopyrrolopyrrole (DPP)-based conjugated polymer nanoparticles (CPNs) an average diameter 109 nm. The CPN were designed to include...