A5044002992- Lipid Membrane Structure and Behavior
- Antioxidant Activity and Oxidative Stress
- Vitamin C and Antioxidants Research
- Cancer Cells and Metastasis
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Nanopore and Nanochannel Transport Studies
- Sphingolipid Metabolism and Signaling
- Antimicrobial Peptides and Activities
- Hemoglobin structure and function
- Plant-based Medicinal Research
- Chemical synthesis and alkaloids
- RNA Interference and Gene Delivery
- Inhalation and Respiratory Drug Delivery
- Surfactants and Colloidal Systems
- Neuroscience of respiration and sleep
- Fuel Cells and Related Materials
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Silicone and Siloxane Chemistry
- Advanced NMR Techniques and Applications
- RNA and protein synthesis mechanisms
- Metabolomics and Mass Spectrometry Studies
- Cellular transport and secretion
- Alkaloids: synthesis and pharmacology
University of Windsor
2012-2025
McMaster University
2024
Windsor Dermatology
2019-2020
Despite the prevalence of lipid transbilayer asymmetry in natural plasma membranes, most biomimetic model membranes studied are symmetric. Recent advances have helped to overcome difficulties preparing asymmetric liposomes vitro, allowing for examination a larger set relevant biophysical questions. Here, we investigate stability bilayers by measuring flip-flop with time-resolved small-angle neutron scattering (SANS). Asymmetric large unilamellar vesicles inner bilayer leaflets containing...
The outbreak of electronic-cigarette/vaping-associated lung injury (EVALI) has made thousands ill. This been attributed to a physical interaction between toxicants from the vaping solution and pulmonary surfactant. In particular, studies have implicated vitamin E acetate as potential instigator EVALI. Pulmonary surfactant is vital proper respiration through mechanical processes adsorption interface stability achieve maintain low surface tension at air-liquid interface. Using neutron spin...
The popularity of electronic cigarettes and vaping products has launched the outbreak a condition affecting respiratory system users, known as electronic-cigarette/vaping-associated lung injury (EVALI). build-up vitamin E acetate (VEA), diluent some illicit oils, in bronchoalveolar lavage patients with EVALI provided circumstantial evidence target for investigation. In this work, we provide fundamental characterization interaction VEA cells pulmonary surfactant (PS) models to explore...
Neutron spin-echo (NSE) spectroscopy to measure the bending fluctuations of large unilamellar vesicles having an asymmetric transbilayer distribution high- and low-melting lipids. Image by Kayle Kathleen Marie Gorospe University Windsor Science Meets Art program.
Time-resolved SANS showed alamethicin and melittin promote DMPC lipid vesicle mixing perturb kinetics in similar ways.
Cellular membranes are responsible for absorbing the effects of external perturbants cell's survival.
Glioblastoma is one of the most aggressive types cancer with success therapy being hampered by existence treatment resistant populations stem-like Tumour Initiating Cells (TICs) and poor blood-brain barrier drug penetration. Therapies capable effectively targeting TIC population are in high demand. Here, we synthesize spherical diketopyrrolopyrrole-based Conjugated Polymer Nanoparticles (CPNs) an average diameter 109 nm. CPNs were designed to include fluorescein-conjugated Hyaluronic Acid...
In this review, we delve into the topic of pulmonary surfactant (PS) system, which is present in respiratory system. The total composition PS has been presented and explored, from types cells involved its synthesis secretion, down to specific building blocks used, such as various lipid protein components. varies across species between individuals, but ultimately produces a monolayer with same role. As such, investigated for ways it imposes function confers peculiar biophysical...
Take your vitamins, or don't? Vitamin E is one of the few lipophilic vitamins in human diet and considered an essential nutrient. Over years it has proven to be a powerful antioxidant commercially used as such, but this association far from linear physiology. It increasingly more likely that vitamin multiple legitimate biological roles. Here, we review past current work using neutron X-ray scattering elucidate influence on key features model membranes can translate function(s) E. Although...
Despite its discovery over 95 years ago, the biological and nutritional roles of vitamin E remain subjects much controversy. Though it is known to possess antioxidant properties, recent assertions have implied that may not be limited this function in living systems. Through densitometry measurements small-angle X-ray scattering we observe favorable interactions between α-tocopherol unsaturated phospholipids, with more correlating an increase lipid chain unsaturation. Our data provide...
The function of vitamin E in biomembranes remains a prominent topic discussion. As its limitations as an antioxidant persist and novel functions are discovered, our understanding the role becomes increasingly enigmatic. group lipophilic molecules (tocopherols tocotrienols), has been shown to influence properties host membrane, wealth research connected polyunsaturated fatty acid (PUFA) lipids. Here, we use contrast-matched small-angle neutron scattering differential scanning calorimetry...
In recent years, vaping has increased in both popularity and ease of access. This led to an outbreak a relatively new condition known as e-cigarette/vaping-associated lung injury (EVALI). can be caused by physical interactions between the pulmonary surfactant (PS) lungs toxins typically found solutions, such medium chain triglycerides (MCT). MCT been largely used carrier agent within many cannabis products commercially available on market. Pulmonary ensures proper respiration maintaining low...
Pancratistatin (PST) is a natural antiviral alkaloid that has demonstrated specificity toward cancerous cells and explicitly targets the mitochondria. PST initiates apoptosis while leaving healthy, noncancerous unscathed. However, manner by which induces remains elusive impedes advancement of as anticancer therapeutic agent. Herein, we use neutron spin–echo (NSE) spectroscopy, molecular dynamics (MD) simulations, supporting small angle scattering techniques to study PST's effect on membrane...
Glioblastoma is one of the most aggressive types cancer with median survival only 15 months. Successful therapy hampered by existence treatment resistant populations stem-like tumour initiating cells (TICs) and poor blood-brain barrier drug penetration. Therapies capable effectively targeting TIC population are in high demand. Here, we synthesize spherical diketopyrrolopyrrole (DPP)-based conjugated polymer nanoparticles (CPNs) an average diameter 109 nm. The CPN were designed to include...
Glioblastoma is one of the most aggressive types cancer with median survival only 15 months. Successful therapy hampered by existence treatment resistant populations stem-like tumour initiating cells (TICs) and poor blood-brain barrier drug penetration. Therapies capable effectively targeting TIC population are in high demand. Here, we synthesize spherical diketopyrrolopyrrole (DPP)-based conjugated polymer nanoparticles (CPNs) an average diameter 109 nm. The CPN were designed to include...
Liposomes have been recognized as an ideal drug delivery system due to their amphiphilic properties, allowing the entrapment of both hydrophobic and hydrophilic drugs.Liposomal systems are typically composed phospholipids, which biocompatible a low toxicity, making them for arrangements.