To detect macrophages in atherosclerotic plaques, plasmonic gold nanoparticles are introduced as a contrast agent for intravascular photoacoustic imaging. The phantom and ex vivo tissue studies show that the individual spherical nanoparticles, resonant at 530 nm wavelength, produce weak signal 680 wavelength while from internalized by is very strong due to plasmon resonance coupling effect. These results suggest imaging can assess macrophage-mediated aggregation of therefore identify...

The potential of intravascular photoacoustic (IVPA) imaging to detect atherosclerosis was previously demonstrated using a 532 nm nanosecond pulsed laser and an ultrasound (IVUS) catheter. However, differentiate vulnerable plaques, the composition plaques needs be imaged. Therefore, we introduce multi-wavelength method distinguish various types plaques. Multi-spectral IVPA ex vivo samples normal atherosclerotic rabbit aorta performed at several wavelengths within 680-900 range. spectral...

Catheter-based imaging of atherosclerosis with high resolution, albeit invasive, is extremely important for screening and characterization vulnerable plaques. Currently, there a need an technique capable providing comprehensive morphological functional information In this paper, we present intravascular photoacoustic to characterize plaques by using optical absorption contrast between normal tissue atherosclerotic lesions. Specifically, investigate the feasibility obtaining (IVPA) images...

Sustainability is maintained by regular practices, but many factors may directly or indirectly affect sustainability in the construction industry. This paper introduces an enhancement manageability to improve that can actualize some imperative with help of ANN framework approach. The primary approach this discover present variables influence supportability development considers qualitative meta-analysis for collecting all information and contents. major problems sub-problems are identified...

Sustainability has become an important focus in the construction industry due to growing environmental concerns, resource depletion, and urgency reduce greenhouse gas emissions. The sector contributes significantly world’s carbon emissions energy consumption, making it a prime candidate for sustainable transformation. In response these challenges, there been shift towards utilizing earth-based products, especially earth blocks, as alternatives. Compressed stabilized blocks (CSEBs) are...

The imaging of plaque composition represents one the important steps in interventional management atherosclerosis. Intravascular photoacoustic (IVPA) has potential to play a major role detection and differentiation an atherosclerotic lesion. difference optical properties arterial wall constituents could be utilized obtain high resolution images. In this work, through ex vivo studies using rabbit model atherosclerosis, we evaluate ability IVPA detect characterize plaque. Specifically,...

Combination of three complementary imaging technologies - ultrasound imaging, elastography, and optoacoustic is suggested for detection diagnostics tissue pathology including cancer. The fusion these ultrasound-based techniques results in a novel system capable simultaneous the anatomy (ultrasound imaging), cancer-induced angiogenesis (optoacoustic imaging) changes mechanical properties (elasticity to uniquely identify differentiate at various stages. To evaluate our approach, analytical...

An advanced in-vivo imaging technology; namely, combined ultrasound, elasticity and photoacoustic imaging, capable of visualizing both structural functional properties living tissue, is presented. This hybrid technology based on the fusion complementary modalities takes full advantage many synergistic features these systems. To highlight fundamental differences similarities between systems to appreciate advantages limitations each system, basic physics system described. The experimental...

We describe a differential phase low-coherence interferometric probe for non-invasive, quantitative imaging of photothermal phenomena in biological materials. Our detection method utilizes principles optical coherence tomography with measurement interference fringe signals. A dual-channel is used to analyse laser-induced thermoelastic and thermorefractive effects tissue micrometre axial resolution nanometre sensitivity. demonstrate an application the technique using phantoms ex-vivo...

We are studying a new method for estimating blood volume flow that uses 3-dimensional ultrasound to measure the total integrated flux through an ultrasound-generated Gaussian surface intersects umbilical cord. This makes none of assumptions typically required with standard 1-dimensional spectral Doppler estimates. compared variations in estimates between techniques vein.The study was Institutional Review Board approved, and all 12 patients gave informed consent. Because we had no reference...

Intravascular ultrasound (IVUS) imaging has emerged as an technique to evaluate coronary artery diseases including vulnerable plaques. However, in addition the morphological characteristics provided by IVUS imaging, there is a need for functional capability that could identify composition of photoacoustic (IVPA) conjunction with clinically available may be such allowing plaque characterization and differentiation. We have developed integrated intravascular system visualize relevant...

There is a need for an imaging technique that can reliably identify and characterize the vulnerability of atherosclerotic plaques. Catheter-based intravascular ultrasound (IVUS) one tools clinical evaluation atherosclerosis. However, histopathological information obtained with IVUS limited. We present discuss applicability combined photoacoustic (IVPA) approach to assess both vessel structure tissue composition thus identifying rupture-prone Photoacoustic (or optoacoustic and, generally,...

Diagnosis and treatment of atherosclerosis necessitates the detection differentiation rupture prone plaques. In principle, intravascular photoacoustic (IVPA) imaging has ability to simultaneously visualize structure composition atherosclerotic plaques by utilizing difference in optical absorption. Extensive studies are required validate utility IVPA detecting vulnerable address issues associated with clinical implementation technique. this work, we performed <i>ex vivo </i>imaging using a...

Ultrasound-mediated delivery (USMD) of novel therapeutic agents in the presence microbubbles is a potentially safe and effective method for gene therapy offering many desired characteristics, such as low toxicity, potential repeated treatment, organ specificity. In this study, we tested capability USMD to improve expression mice livers using glycogen storage disease Type Ia model under systemic administration naked plasmid DNA. Image-guided ultrasound was used two studies provide livers....

Atherosclerosis is a systemic disease characterized by the development of plaque leading to several acute coronary syndromes. Imaging structure and composition important in diagnosing further guiding interventions. Currently, there no clinical imaging technique capable providing comprehensive morphological functional information plaques. Several emerging techniques including palpography thermography are under investigation for intravascular atherosclerosis. In this paper we present...

Intravascular photoacoustic (IVPA) imaging can image atherosclerotic plaques inside the artery by utilizing differences in optical absorption between various tissue types. Combined intravascular ultrasound (IVUS) and IVPA has potential to visualize both structure composition of plaques. However, molecular or cellular specific components be further enhanced introducing plasmonic nanoparticles as molecularly targeted contrast agents. To demonstrate that with agents is possible, we performed...

An ultrasonic interferometric sensor has been introduced for the measurement of subtle changes in physical properties fluids such as density, viscosity, and bulk modulus. Tone burst waves are generated using a single peizocrystal bonded between two solid delay line media slightly different lengths. One side is contact with reference fluid (with known properties) other whose to be measured. The reflect from solid-fluid boundaries received back by where interference effects longitudinal were...

In many clinical and research applications including cancer diagnosis, tumor response to therapy, reconstructive surgery, monitoring of transplanted tissues organs, quantitative evaluation angiogenesis, sequential assessment microcirculation in tissue is required. this paper we present an imaging technique capable spatial temporal measurements blood perfusion through microcirculation. To demonstrate the developed technique, studies were conducted using phantoms with modeled small vessels...

Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Twitter Facebook Reddit LinkedIn Tools Reprints and Permissions Cite Search Site Citation Ajay Anand, John Petruzzello, Shiwei Zhou, Shriram Sethuraman, Jose Azevedo; Two‐Dimensional Real‐time Ultrasound Technique to Control Lesion Size during HIFU Therapy. AIP Conf. Proc. 9 March 2010; 1215 (1): 79–82. https://doi.org/10.1063/1.3367201 Download citation file: Ris (Zotero) Reference Manager EasyBib...

Monitoring of radiofrequency ablation (RFA) is essential to ensure accurate treatment coverage large liver tumors. Ultrasound an excellent option for monitoring ablations. Since ultrasound B-mode imaging lacks the ability precisely estimate extent lesion, there has been considerable effort and interest in other based techniques. thermometry one such technique that potential monitor thermal However, drawback approach its applicability only sub-ablative temperatures. We attempt overcome this...

The reliability of automated image interpretation point-of-care (POC) echocardiography scans depends on the quality acquired ultrasound data. This work reports development and validation spatiotemporal deep learning models to assess suitability input cine loops collected using a handheld device for processing by an quantification algorithm (e.g. ejection fraction estimation). POC echocardiograms (n=885 DICOM from 175 patients) two sites were annotated at frame-level. Attributes high-quality...