A5056699531- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cell Adhesion Molecules Research
- Circular RNAs in diseases
- Immune Response and Inflammation
- RNA Research and Splicing
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Caveolin-1 and cellular processes
- Immune cells in cancer
Nanchang University
2022-2024
First Affiliated Hospital of Jiangxi Medical College
2024
Rationale: Breast cancer (BC), as one of the most frequently diagnosed cancer, has a poor prognosis due to development distant metastasis. Among BC metastatic sites, lung is common sites. Caveolin-1 (Cav-1) functional membrane protein that plays vital role in tumor Although studies have revealed Cav-1 levels were elevated patients with advanced whether affects metastasis by influencing formation pre-metastatic niche (PMN) through exosomes not been explored. Methods: Differential...
In recent years, malignant breast cancer metastasis has caused a great increase in mortality. Research on the genetic and molecular mechanisms of continued to deepen, targeted therapy become general trend. Among them, competing endogenous RNA (ceRNA)-related molecules have received much attention. Homeobox transcript antisense (HOTAIR) been reported function extensively as ceRNA cancer. Notably, miR-203 Caveolin 1 (CAV1) also found play role However, relationship between three remains...
YTH N6-methyladenosine RNA binding protein 1 (YTHDF1), an m6A reader, has a role in the development and progression of breast cancer as well immunological microenvironment. The networks competing endogenous have received much attention research. In tumor gene therapy, regulatory are increasingly emerging new route. We evaluated relationship between YTHDF1 expression, overall survival, clinicopathology using TCGA, PrognoScan, other datasets. used Western blot to demonstrate that is...
Lung metastasis in breast cancer (BC) patients is one of the main reasons for their high mortality rate. The most prevalent BC small extracellular vesicles (sEVs receptor, integrin α6β4, has been found to interact with surfactant-associated protein (SFTPC) lung epithelial cells, making more likely metastasize lung. Tumor-associated neutrophils (TANs) play an essential role as a component pre-metastatic niche (PMN) two sides. It demonstrated that Toll-like Receptor4 (TLR4) can participate...