A5043614092- Nerve injury and regeneration
- Pain Mechanisms and Treatments
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Pancreatic function and diabetes
- Botulinum Toxin and Related Neurological Disorders
- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Infrastructure Maintenance and Monitoring
- Spinal Cord Injury Research
- Diabetes Management and Research
- Phytochemicals and Antioxidant Activities
- Axon Guidance and Neuronal Signaling
- Metabolism, Diabetes, and Cancer
- Biochemical Analysis and Sensing Techniques
- Biochemical effects in animals
- melanin and skin pigmentation
- Ubiquitin and proteasome pathways
- Periodontal Regeneration and Treatments
- Innovative Microfluidic and Catalytic Techniques Innovation
- Calpain Protease Function and Regulation
- 3D Surveying and Cultural Heritage
- Smart Agriculture and AI
- Neurogenesis and neuroplasticity mechanisms
Nanyang Technological University
2024
Ho Chi Minh City University of Industry and Trade
2021-2024
Pukyong National University
2023
National University of Singapore
2019-2023
Kansai Medical University
2015-2019
Vietnam National University Ho Chi Minh City
2014-2018
Ho Chi Minh City University of Science
2018
Mesenchymal stem cells (MSCs) are an attractive source of for clinical applications. These exhibit a multilineage differentiation potential and strong capacity immune modulation. Thus, MSCs widely used in cell therapy, tissue engineering, immunotherapy. Because important advantages, umbilical cord blood-derived (UCB-MSCs) have attracted interest some time. However, the applications UCB-MSCs limited by small number recoverable fetal bovine serum (FBS)-dependent expansion methods. Hence, this...
Abstract Peripheral neuropathy is one of the most common and serious complications type‐2 diabetes. Diabetic characterized by a distal symmetrical sensorimotor polyneuropathy, its incidence increases in patients 40 years age or older. In spite extensive research over decades, there are few effective treatments for diabetic besides glucose control improved lifestyle. The earliest changes occur sensory nerve fibers, with initial degeneration regeneration resulting pain. To seek treatment, here...
Diabetes mellitus is a high incidence disease that has increased rapidly in recent years. Many new therapies are being studied and developed order to find an effective treatment. An ideal candidate stem cell therapy. In this study, we investigated the differentiation of adipose derived cells (ADSCs) into pseudo-islets defined medium vitro, produce large quantities insulin-producing (IPCs) for transplantation. ADSCs isolated from tissue were induced differentiate islet-like clusters vitro by...
The restoration of function to injured peripheral nerves separated by a gap requires regeneration across it and reinnervation target organs. To elucidate these processes, we have established an in vivo monitoring system nerve thy1-yellow fluorescent protein transgenic mice expressing their nervous system. Here demonstrated that motor sensory were regenerated coordinated fashion the functional recovery response mechanical stimuli correlated well with innervation foot. Among mitogen-activated...
Diabetic polyneuropathy (DPN) renders progressive sensory neurodegeneration linked to hyperglycemia and its associated metabolopathy. We hypothesized that there may be additive impacts of direct insulin signaling, independent glycemia phosphatase tensin homolog deleted on chromosome 10 (PTEN) knockdown neuropathy. Our targets for combined interventions were neurons Schwann cells (SCs) in vitro chronic type 1 DPN mice. Insulin receptor expression was not altered by high-glucose conditions or...
Abstract We have recently demonstrated that endothelin ( ET ) is functionally coupled to Na x , a + concentration‐sensitive channel for lactate release via receptor type B R and involved in peripheral nerve regeneration sciatic transection–regeneration mouse model. known interact directly with /K ‐ ATP ase, leading production the brain. To investigate role of ase regeneration, this study, we applied ouabain, inhibitor, cut site 4 weeks an osmotic pump. While functional recovery reinnervation...
Type 1 diabetes mellitus is characterized by the destruction of pancreatic islet beta cells, which leads to insulin insufficiency, hyperglycemia, and reduced metabolic glucose level. Insulin replacement current standard therapy for type but has several limitations. Pancreatic transplantation can result in production exogenous insulin, its use limited immune-rejection donor availability. Recent studies have shown that mesenchymal stem cells (MSCs) transdifferentiate into insulin-producing...
The authors established an in vitro model of diabetic neuropathy based on the culture system primary neurons and Schwann cells (SCs) to mimic similar symptoms observed vivo models this complication, such as impaired neurite extension myelination. was then utilized investigate effects insulin enhancing myelination neurons.SCs were cultured under conditions mimicking hyperglycemia prepared by adding glucose basal medium. In a single culture, proliferation maturation SCs evaluated. co-culture,...
Real-time monitoring of the behavior reinforced soil retaining wall (RSW) is required for safety checks. In this study, a targetless RSW technology (TRMT) consisting image registration module and displacement calculation was proposed to monitor RSW, in which facing settlement typically occur. Laboratory field experiments on were conducted compare performances natural target (NT) with artificial (AT). Feature count- location-based performance analyzed determine their correlations. The...
Introduction: Human adipose derived stem cells (hASCs) have great potential for regenerative medicine. The demand hASCs, especially in the development of off-the-shelf products, is increasing. Although initial receipt hASCs was relatively limited, there now greater interest and also awareness that vitro expansion be further explored. purpose this study to assess integrity mesenchymal cell characteristics mutant capability chromosome number on undergoing expansion. Methods: In study, three...