A5101892820- Mesenchymal stem cell research
- Cytokine Signaling Pathways and Interactions
- Pharmacological Effects of Natural Compounds
- Tissue Engineering and Regenerative Medicine
- Wnt/β-catenin signaling in development and cancer
- Electrospun Nanofibers in Biomedical Applications
- Neonatal Respiratory Health Research
- Family Support in Illness
- Adrenal Hormones and Disorders
- International Business and FDI
- Global trade and economics
- Immune Response and Inflammation
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Cancer survivorship and care
- 3D Printing in Biomedical Research
- Medicinal Plant Pharmacodynamics Research
- Biotechnology and Related Fields
- Science, Research, and Medicine
- Animal Virus Infections Studies
- Congenital heart defects research
- Galectins and Cancer Biology
- Cancer, Lipids, and Metabolism
- Plant-based Medicinal Research
- Research on Leishmaniasis Studies
National Hospital of Pediatrics
2023
Hospital for Tropical Diseases
2023
The University of Queensland
2014-2022
Konkuk University
2016-2022
Translational Research Institute
2014-2018
Vietnam National University Ho Chi Minh City
2012-2017
Ho Chi Minh City University of Science
2012-2017
James Cook University
2013
Oxford University Clinical Research Unit
1995
Mesenchymal stem cells (MSCs) are an attractive source of for clinical applications. These exhibit a multilineage differentiation potential and strong capacity immune modulation. Thus, MSCs widely used in cell therapy, tissue engineering, immunotherapy. Because important advantages, umbilical cord blood-derived (UCB-MSCs) have attracted interest some time. However, the applications UCB-MSCs limited by small number recoverable fetal bovine serum (FBS)-dependent expansion methods. Hence, this...
Key Points Differential expression of WNT ligands in patients with septic shock and a mouse model endotoxemia correlates inflammatory cytokines. WNT/β-catenin signaling positively regulate lipopolysaccharide-induced pro-inflammatory cytokines without impairing IL-10.
The in vitro activities of 14 antimicrobial agents were determined for 78 strains Yersinia pestis. most active antibiotics ceftriaxone and ciprofloxacin, followed by ofloxacin ampicillin. traditionally used the treatment plague (streptomycin, tetracycline, chloramphenicol) considerably less active. Azithromycin showed poor activity against all strains.
An increasing number of studies address the roles Wnt proteins in shaping leukocyte functions. Recombinant Wnt3a and Wnt5a, prototypical activators β-Catenin-dependent -independent signaling, respectively, are widely used to investigate effects on myeloid cell Recent reports describe both proinflammatory immunemodulatory Wnt5a macrophages, DCs, microglia. The underlying molecular mechanisms for this divergence unclear. We show here that recombinant Wnt3a- Wnt5a-induced cytokine production...
AAA (abdominal aortic aneurysm) is an important cause of sudden death in older adults, but there no current effective drug therapy for this disease. The UCNs (urocortins1-3) and their receptors: CRFR (corticotrophin-releasing factor receptor)-1 -2 have been implicated various CVDs (cardiovascular diseases). We assessed the relative expression UCN1-3 by qRT-PCR (quantitative reverse transcription-PCR) ELISA, examined vitro how UCN2 affects human VSMC (vascular smooth muscle cell) Akt...
Natural Killer T (NKT) cells are prominent innate-like lymphocytes in the liver with critical roles immune responses during infection, cancer and autoimmunity. IFN-g IL-4 key cytokines rapidly produced by NKT upon recognition of glycolipid antigens presented antigen presenting (APCs). It has previously been reported that transcriptional co-activator b-catenin regulates cell differentiation functionally biases towards IL-4, at expense production. is a central effector Wnt signaling but also...
A hallmark of Listeria (L . ) monocytogenes pathogenesis is bacterial escape from maturing entry vacuoles, which required for rapid replication in the host cell cytoplasm and cell-to-cell spread. The transcriptional activator PrfA controls expression key virulence factors that enable exploitation this intracellular niche. activity within infected cells controlled by allosteric coactivation. Inhibitory occupation coactivator site has been shown to impair functions, but consequences inhibition...
Cytokines are significantly associated with the homeostasis of immune responses in health and disease. Interleukin-32 (IL-32) is a cytokine originally discovered natural killer cell transcript 4. IL-32 different disorders has been described terms pathogenesis progression diseases. Clinical studies have investigated under various conditions, such as viral infection, autoimmune diseases, inflammatory certain types cancer, vascular disease, pulmonary The high expression was identified tissues...
It has been reported that fatty acid binding proteins (FABPs) do not act only as intracellular mediators of lipid responses but also have extracellular functions. This study aimed to investigate whether liver type (L)-FABP a biological activity and determined serum L-FABP levels in patients with end-stage renal disease (ESRD). We isolated complementary deoxyribonucleic (cDNA) from the Huh7 human hepatocarcinoma cell line expressed recombinant protein Escherichia coli. A549 lung carcinoma...
The induction of interleukin (IL)-32 in bone marrow (BM) inflammation is crucial graft versus host disease (GvHD) that a common side effect allogeneic BM transplantation.Clinical trials on a-1 antitrypsin (AAT) patients with GvHD are based the preliminary human and mouse studies AAT reducing severity GvHD.Proteinase 3 (PR3) an IL-32-binding protein was isolated from urine.IL-32 primarily induces inflammatory cytokines myeloid cells, probably due to PR3 expression membrane lineage cells.The...
Virus-like particles (VLPs) derived from human papillomavirus (HPV) L1 capsid proteins were used for HPV quadrivalent recombinant vaccine.The vaccine is administrated in a 3-dose regimen of initial injection followed by subsequent doses at 2 and 6 months to prevent cervical cancer, vulvar, vaginal cancers.The type 6, 11, 16, or 18 infection associated with precancerous lesions genital warts adolescents young women.The composed viral are produced eukaryotic expression systems purified the...
Recently, stem cell therapy has been investigated as a strategy to prevent or reverse damage heart tissue. Although the results of transplantation in animal models and patients with myocardial ischemia are promising, selection appropriate type remains an issue that requires consideration. In this study, we aimed evaluate effect cardiac progenitor mouse model ischemia. The cells used for were differentiated from umbilical cord blood mesenchymal cells. Animal injected phosphate-buffered saline...
In the current, cardiovascular disease is one of leading causes death in World. Coronary artery blockage acute myocardial infarction that makes tissue damaged and can be fatal some cases. If patients overcome infarctions, obstruction long run will lead to ischemia then cell ischemic myocardium area. So far there no method prevent effectively lesions, development an animal model injury necessary for studying new therapies treatment. This study aimed create a mouse injury. An occluding suture...
Interferons (IFNs) have been known as antiviral genes and they are classified by type 1, 2, 3 IFN.The 1 IFN consists of IFNα, IFNβ, IFNτ, IFNω whereas the 2 only IFNγ, which is a key cytokine driving T helper cell immunity.IFNλ belongs to IFN, also IL-28 IL-29 possessing activities.Type produced viral infection induced mitogenic or antigenic T-cell stimuli.The IFNτ bovine was first discovered in an ungulate ruminant recognition hormone.IFNτ with common feature such activity.IFNs mostly...