A5006044247- Ubiquitin and proteasome pathways
- Erythrocyte Function and Pathophysiology
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Drug-Induced Adverse Reactions
- Immunodeficiency and Autoimmune Disorders
- Autophagy in Disease and Therapy
- Urticaria and Related Conditions
- Geographic Information Systems Studies
- Chronic Lymphocytic Leukemia Research
- RNA and protein synthesis mechanisms
- Ferroptosis and cancer prognosis
- Microtubule and mitosis dynamics
- Tea Polyphenols and Effects
- Pharmacological Effects and Toxicity Studies
- ATP Synthase and ATPases Research
- Listeria monocytogenes in Food Safety
- Vibrio bacteria research studies
- Coastal and Marine Management
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Computational Drug Discovery Methods
- Coral and Marine Ecosystems Studies
- Linguistic research and analysis
- Peptidase Inhibition and Analysis
The University of Sydney
2025
Max Planck Institute of Biochemistry
2022-2024
John Wiley & Sons (United States)
2023
Hudson Institute
2023
Liechtenstein Institute
2023
The University of Queensland
2022
Research Center Borstel - Leibniz Lung Center
2020-2021
Federal Agency for Nature Conservation
2006
Abstract Toxic epidermal necrolysis (TEN) is a fatal drug-induced skin reaction triggered by common medications and an emerging public health issue 1–3 . Patients with TEN undergo severe sudden detachment caused keratinocyte cell death. Although molecular mechanisms that drive death have been proposed, the main drivers remain unknown, there no effective therapy for 4–6 Here, to systematically map changes are associated identify potential druggable targets, we utilized deep visual proteomics,...
The yeast glucose-induced degradation-deficient (GID) E3 ubiquitin ligase forms a suite of complexes with interchangeable receptors that selectively recruit N-terminal degron motifs metabolic enzyme substrates. orthologous higher eukaryotic C-terminal to LisH (CTLH) complex has been proposed also recognize substrates through an alternative subunit, WDR26, which promotes the formation supramolecular CTLH assemblies. Here, we discover human WDR26 binds...
Amino acid (AA) detection is fundamental for cellular function, balancing translation demands, biochemical pathways, and signaling networks. While the GCN2 mTORC1 pathways are known to regulate AA sensing, global response deprivation remains poorly understood, particularly in non-transformed cells, which may exhibit distinct adaptive strategies compared cancer cells. Here we employed murine pluripotent embryonic stem (ES) cells as a model system dissect responses stress. Using multi-omics...
In view of emerging drug-resistant tuberculosis (TB), host-directed adjunct therapies are urgently needed to improve treatment outcomes with currently available anti-TB therapies. One approach is interfere the formation lipid-laden "foamy" macrophages in host, as they provide a nutrient-rich host cell environment for Mycobacterium (Mtb). Here, we evidence that Wnt family member 6 (WNT6), ligand evolutionarily conserved Wingless/Integrase 1 (WNT) signaling pathway, promotes foam by regulating...
The development of haematopoietic stem cells into mature erythrocytes - erythropoiesis is a controlled process characterized by cellular reorganization and drastic reshaping the proteome landscape. Failure ordered associated with anaemias haematological malignancies. Although ubiquitin system known crucial post-translational regulator in erythropoiesis, how erythrocyte reshaped poorly understood. By measuring proteomic landscape vitro human models, we found dynamic differential expression...
A hallmark of Listeria (L . ) monocytogenes pathogenesis is bacterial escape from maturing entry vacuoles, which required for rapid replication in the host cell cytoplasm and cell-to-cell spread. The transcriptional activator PrfA controls expression key virulence factors that enable exploitation this intracellular niche. activity within infected cells controlled by allosteric coactivation. Inhibitory occupation coactivator site has been shown to impair functions, but consequences inhibition...
Abstract In our paper we present a multimedia tool which is based on assumption that computers are much better suited in language learning to act an organising and structuring capacity rather than take up role as machine. READERS was developed jointly by team of researchers from the universities Essen Wuppertal headed Bernd Rüschoff (the editor volume) Dieter Wolff. It programme designed help university students—not necessarily students—with difficult business understanding texts foreign...
Abstract Toxic epidermal necrolysis (TEN) is a fatal drug-induced skin reaction and an emerging public health issue. Triggered by common medications, TEN patients undergo severe sudden detachment caused keratinocyte cell death. Although molecular mechanisms driving death have been proposed, the main drivers remain unknown no effective therapy exists. To systematically map changes that are associated with identify potential druggable targets, we employed single- spatial proteomics technique...
Abstract In view of emerging drug-resistant tuberculosis, host directed therapies are urgently needed to improve treatment outcomes with currently available anti-tuberculosis therapies. One option is interfere the formation lipid-laden “foamy” macrophages in infected host. Here, we provide evidence that WNT6, a member evolutionary conserved WNT signaling pathway, promotes foam cell by regulating key lipid metabolic genes including acetyl-CoA carboxylase-2 (ACC2) during pulmonary TB....
Abstract The development of haematopoietic stem cells into mature erythrocytes – erythropoiesis is a controlled process characterized by cellular reorganisation and drastic reshaping the proteome landscape. Failure ordered associated with anaemias haematological malignancies. Although ubiquitin (UB) system known crucial post-translational regulator in erythropoiesis, how erythrocyte reshaped UB poorly understood. By measuring proteomic landscape vitro human models, we found dynamic...