A5089558351- Drug-Induced Adverse Reactions
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Salivary Gland Disorders and Functions
- Diabetes and associated disorders
- Mast cells and histamine
- Vascular Malformations and Hemangiomas
- Cancer Immunotherapy and Biomarkers
- Adrenal Hormones and Disorders
- Autoimmune and Inflammatory Disorders
- Adenosine and Purinergic Signaling
- melanin and skin pigmentation
- Monoclonal and Polyclonal Antibodies Research
- Herpesvirus Infections and Treatments
- Tumors and Oncological Cases
- Diabetes Treatment and Management
- Inflammatory Myopathies and Dermatomyositis
- Immunodeficiency and Autoimmune Disorders
- Cancer and Skin Lesions
- Antiplatelet Therapy and Cardiovascular Diseases
- Abdominal vascular conditions and treatments
- Intramuscular injections and effects
- Systemic Sclerosis and Related Diseases
- Vascular Malformations Diagnosis and Treatment
- Actinomycetales infections and treatment
Niigata University
2020-2025
Nagaoka Red Cross Hospital
2022-2023
National Hospital Organization
2020
Niigata City General Hospital
2019
Abstract Toxic epidermal necrolysis (TEN) is a fatal drug-induced skin reaction triggered by common medications and an emerging public health issue 1–3 . Patients with TEN undergo severe sudden detachment caused keratinocyte cell death. Although molecular mechanisms that drive death have been proposed, the main drivers remain unknown, there no effective therapy for 4–6 Here, to systematically map changes are associated identify potential druggable targets, we utilized deep visual proteomics,...
Abstract Background Repaglinide is widely prescribed to reduce postprandial hyperglycemia and elevated glycated hemoglobin (HbA1c) levels associated with type 2 diabetes, clopidogrel a thienopyridine antiplatelet agent used in cardiovascular cerebrovascular diseases. It has been suggested that the concomitant use of repaglinide may inhibit metabolism, because substrate cytochrome P450 2C8 (CYP2C8) main metabolite acyl-β-D-glucuronide inhibits CYP2C8 activity. In this study, we...
Abstract Toxic epidermal necrolysis (TEN) is a fatal drug-induced skin reaction and an emerging public health issue. Triggered by common medications, TEN patients undergo severe sudden detachment caused keratinocyte cell death. Although molecular mechanisms driving death have been proposed, the main drivers remain unknown no effective therapy exists. To systematically map changes that are associated with identify potential druggable targets, we employed single- spatial proteomics technique...
2系統の門脈大循環シャントを一期的に閉塞することで症状が改善した肝性脳症の1例を報告する.症例は56歳の男性.膵頭部癌による閉塞性黄疸で初診し,その際肝硬変と,脾腎,腸間膜下大静脈,腸間膜右腎シャントが認められた.Child-Pugh 10点 C gradeと肝予備能は低く,膵癌の根治手術を断念した.その後徐々に肝性脳症が出現し,意識障害のため入院を反復して内科治療抵抗性と判断した.3系統のシャントのうち,脾腎,腸間膜下大静脈シャントに対して一期的にバルーン下逆行性経静脈的塞栓術(BRTO)を施行し,その後は脳症顕性化を認めず,術前Child-Pugh 12点から術後7-8点へ改善した.本例では肝性脳症が本人の尊厳と家族の生活を著しく損ねており,また膵癌の病勢も比較的落ち着いていたため,治療適応とした.内科治療に抵抗性の肝性脳症に対して,BRTOが有効な治療法の一つになると考えられた.
Abstract Background: Autoimmune polyendocrine syndromes (APSs) are relatively rare clinical conditions characterized by functional impairment of multiple endocrine glands due to loss immune tolerance. These broadly categorized as monogenic forms, such APS-1, and a more common polygenic variety, APS-2. In APS-2, many autoimmune can develop, including rheumatic diseases. However, systemic sclerosis myositis occur quite rarecomplications, for which no treatment strategy has yet been...
Autoimmune polyendocrine (or polyglandular) syndrome (APS) is a relatively rare clinical condition characterized by functional impairment of multiple endocrine glands due to loss immune tolerance. APS broadly categorized as monogenic forms, such autoimmune type 1 (APS-1), and more common polygenic variety, 2 (APS-2). Although many conditions including rheumatic diseases can develop in APS-2, systemic sclerosis or myositis complication quite no treatment strategy has yet been established. A...
33歳，男性。母と母方従伯母，2人の再従姉に悪性黒色腫の家族歴がある。17歳時に腰部の黒色斑を，21歳時に左母指爪甲色素線条を切除され，それぞれ表在拡大型悪性黒色腫（SSM），末端黒子型悪性黒色腫と診断された。32歳時，背部と左下腿の黒色斑を切除され，いずれもSSM in situと診断された。これまで欧米では家族性悪性黒色腫の主要な原因遺伝子としてCDKN2A，CDK4の変異が報告されており，近年もBAP1，POT1,TERTなどの遺伝子変異が報告されている。我々が調べ得た限り本邦で過去に遺伝子解析を行った家系は2家系であるが，未だ遺伝子変異の同定はない。自験例でもwhole exome sequencingを行ったが，明らかな病的変異は認められなかった。今後さらに症例を集積し，本邦での家族性悪性黒色腫における遺伝子変異の有無や傾向を明らかにすることが望まれる。