A5015721155- Cutaneous lymphoproliferative disorders research
- Vascular Tumors and Angiosarcomas
- Cutaneous Melanoma Detection and Management
- Autoimmune Bullous Skin Diseases
- Oral and gingival health research
- melanin and skin pigmentation
- Drug-Induced Adverse Reactions
- Fungal Infections and Studies
- Cancer and Skin Lesions
- Tumors and Oncological Cases
- Wound Healing and Treatments
- Infectious Diseases and Tuberculosis
- Otitis Media and Relapsing Polychondritis
- Melanoma and MAPK Pathways
- Cancer Immunotherapy and Biomarkers
- Neurofibromatosis and Schwannoma Cases
- RNA regulation and disease
- Dermatological and COVID-19 studies
- Antifungal resistance and susceptibility
- Infections and bacterial resistance
- Dermatologic Treatments and Research
- Pituitary Gland Disorders and Treatments
- CAR-T cell therapy research
- IgG4-Related and Inflammatory Diseases
- Myasthenia Gravis and Thymoma
Niigata University
2017-2025
Niigata Cancer Center Hospital
2022
GTx (United States)
2017
Kitasato University
2017
Mycosis fungoides (MF), the most common subtype of cutaneous T-cell lymphoma (CTCL), typically progresses through patch, plaque, and tumor stages, with various clinical histopathological variants. Diagnosing early-stage MF (stage IA–IIA) is challenging because its differing features similarity to benign inflammatory skin disorders (ISDs), often leading diagnostic errors repeated biopsies. Recent reports suggesting an association between dupilumab, a human monoclonal antibody targeting...
We conducted a nationwide survey in Japan to clarify the clinical spectrum of these events. An initial questionnaire was sent 126 dermatology facilities, and responses were obtained from 66 (52.4%). Among responding most commonly identified cutaneous adverse events after COVID-19 vaccination urticaria (49 (74.2%)), delayed local reactions (37 (56.1%)), erythema multiforme (31 (47.0%)), alopecia (30 (45.5%)). The primary (19 (20.9%)), bullous pemphigoid (7 (7.7%)), (6 (6.6%)). mean latency...
Nivolumab is an antibody against programmed cell death 1 and functions as immune checkpoint inhibitor for various malignancies, including unresectable melanomas. causes several immune-related adverse events, which typically include skin rash, pneumonitis, thyroid dysfunction, hepatitis, colitis; in rare cases, anemia may be present. There are reports of autoimmune hemolytic that has developed response to nivolumab; however, there few pure red aplasia (PRCA). We describe a patient who PRCA...
Tie-over bolster dressing after skin grafting can prolong operative time, and cause hematoma seroma formation because of uneven pressure application. To describe the possibility discontinuing use tie-over dressing, we carried out a retrospective comparative study patients who underwent at an institution between January 2009 December 2014. We investigated compared take rate, healing period, wound infection rate for group non-tie-over group. Among 266 patients, 148 118 were included in group,...
Neurocutaneous melanosis (NCM) is a rare congenital neurocutaneous syndrome characterized by melanocytic nevus of skin and abnormal proliferation leptomeningeal melanocytes. Early acquisition post-zygotic somatic mutations has been postulated to underlie the pathogenesis NCM. The NCM remains be fully elucidated, treatment options have not established. Here, we report for first time, multiregional genomic analyses in 3-year-old autopsied girl with melanomatosis associated NCM, which...
Although the efficacy of dermoscopic diagnosis basal cell carcinoma (BCC) has already been established, most studies have conducted in Western countries. However, there are racial differences clinicopathological characteristics BCC, highlighting need for a survey among Asians. Herein, we aimed to investigate diagnostic accuracy dermoscopy 934 Japanese patients with BCC and statistically analyze factors affecting accuracy. We analyzed 5093 skin lesions, including BCCs that were diagnosed...
Abstract Deep dermatophytosis is an invasive and sometimes life‐threatening fungal infection mainly reported in immunocompromised patients. However, a caspase recruitment domain‐containing protein 9 (CARD9) deficiency has recently been to cause deep dermatophytosis. Herein, we report the first Japanese case of associated with CARD9 deficiency. An 80‐year‐old man tinea corporis presented subcutaneous nodules on his left sole. Histopathological findings revealed marked epithelioid cell...
Cutaneous syncytial myoepithelioma (CSM) is a recently recognized variant of characterized by an intradermal proliferation spindled, ovoid, and histiocytoid cells. Immunohistochemically, tumor cells usually show strong expression S-100 protein epithelial membrane antigen (EMA). Here we report case CSM in the thigh 51-year-old Japanese woman. Histopathological findings showed sheet-like growth ovoid with eosinophilic cytoplasm, adipocytic metaplasia was widely observed tumor....
Abstract Neurocutaneous melanosis (NCM) is a rare congenital neurocutaneous syndrome characterized by melanocytic nevus of skin and abnormal proliferation leptomeningeal melanocytes. Early acquisition post-zygotic somatic mutations has been postulated to underlie the pathogenesis NCM. The NCM remains be fully elucidated treatment options have not established. Here, we report for first time, multiregional genomic analyses in 3-year-old autopsied girl with melanomatosis associated NCM, which...
66歳，男性。右前胸部に被覆表皮が紅色の皮下腫瘤を自覚した。近医にて切除されたが，病理検査は施行されなかった。切除1年後同部位に腫瘤の再発を認め，全摘組織では，病理学的に皮膚型皮膚平滑筋肉腫と診断された。側方断端陽性であり，精査，追加治療目的に当科紹介受診した。PET－CTで，右腋窩の腫大したリンパ節にFDGの集積を認め，転移が疑われた。拡大切除と，右腋窩リンパ節生検を施行した。病理組織所見で，原発巣の腫瘍細胞は真皮深層までの浸潤で，腫瘍細胞の残存がみられたが断端は陰性。リンパ節に腫瘍細胞は認めなかった。一般的に予後良好とされる皮膚型の皮膚平滑筋肉腫であっても真皮深層にまで腫瘍細胞の浸潤を認めたため，慎重な経過観察が必要と考えた。
33歳，男性。母と母方従伯母，2人の再従姉に悪性黒色腫の家族歴がある。17歳時に腰部の黒色斑を，21歳時に左母指爪甲色素線条を切除され，それぞれ表在拡大型悪性黒色腫（SSM），末端黒子型悪性黒色腫と診断された。32歳時，背部と左下腿の黒色斑を切除され，いずれもSSM in situと診断された。これまで欧米では家族性悪性黒色腫の主要な原因遺伝子としてCDKN2A，CDK4の変異が報告されており，近年もBAP1，POT1,TERTなどの遺伝子変異が報告されている。我々が調べ得た限り本邦で過去に遺伝子解析を行った家系は2家系であるが，未だ遺伝子変異の同定はない。自験例でもwhole exome sequencingを行ったが，明らかな病的変異は認められなかった。今後さらに症例を集積し，本邦での家族性悪性黒色腫における遺伝子変異の有無や傾向を明らかにすることが望まれる。