A5010086734- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Contact Dermatitis and Allergies
- Autoimmune Bullous Skin Diseases
- Mast cells and histamine
- Drug-Induced Adverse Reactions
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Exercise and Physiological Responses
- Cutaneous Melanoma Detection and Management
- Psoriasis: Treatment and Pathogenesis
- Neuropeptides and Animal Physiology
- Immune Cell Function and Interaction
- Cancer and Skin Lesions
- Ion Channels and Receptors
- Cancer, Stress, Anesthesia, and Immune Response
- Transgenic Plants and Applications
- Advancements in Transdermal Drug Delivery
- Dermatological and COVID-19 studies
Kindai University Hospital
2021-2025
Kyoto University
2013-2023
Kindai University
2022
Nara Medical University
2020
National Center for Geriatrics and Gerontology
2004
Abstract Hypoxia is a hallmark of cancer that strongly associated with invasion, metastasis, resistance to therapy and poor clinical outcome. Tumour hypoxia affects immune responses promotes the accumulation macrophages in tumour microenvironment. However, signals linking tumour-associated macrophage recruitment promotion are incompletely understood. Here we show damage-associated molecular pattern High-Mobility Group Box 1 protein (HMGB1) released by melanoma cells as consequence M2-like an...
In December 2019, a new infectious pathogen named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in Wuhan, China. Transmitted through droplets, SARS-CoV-2 is the causative of disease 2019 (COVID-19). Although this COVID-19 infection known to cause primarily interstitial pneumonia and failure, it often associated with cutaneous manifestations as well. These can be classified into seven categories: (i) chilblain-like skin eruption (e.g., COVID toes), (ii)...
The pathogenesis of atopic dermatitis (AD) is understood to be crucially influenced by three main factors: dysregulation the immune response, barrier dysfunction, and pruritus. In lesional skin AD, various innate cells, including Th2 type 2 lymphoid cells (ILC2s), basophils, produce cytokines [interleukin (IL)-4, IL-5, IL-13, IL-31]. Alarmins such as TSLP, IL-25, IL-33 are also produced epidermal keratinocytes, amplifying inflammation. chronic phase, not only but Th22 Th17 increase in...
Although nivolumab is associated with a significant improvement in overall survival and progression-free survival, only 20 to 40% of patients experience long-term benefit. It therefore great interest identify predictive marker clinical benefit for nivolumab. To address this issue, the frequencies CD4+ T cell subsets (Treg, Th1, Th2, Th9, Th17 Th22), CD8+ cells, serum cytokine levels (IFNγ, IL-4, IL-9, IL-10, TGF-β) were assessed 46 melanoma. Eighteen responded nivolumab, other 28 did not. An...
Recent advances in generative artificial intelligence (AI) have expanded its applications diagnostic support within dermatology, but clinical accuracy requires ongoing evaluation. This study compared the performance of three advanced AI models, ChatGPT-4o, Claude 3.5 Sonnet, and Gemini 1.5 Pro, with that board-certified dermatologists, using a dataset 30 cases encompassing variety dermatological conditions. The models demonstrated comparable to, sometimes exceeding, specialists, particularly...
We conducted a nationwide survey in Japan to clarify the clinical spectrum of these events. An initial questionnaire was sent 126 dermatology facilities, and responses were obtained from 66 (52.4%). Among responding most commonly identified cutaneous adverse events after COVID-19 vaccination urticaria (49 (74.2%)), delayed local reactions (37 (56.1%)), erythema multiforme (31 (47.0%)), alopecia (30 (45.5%)). The primary (19 (20.9%)), bullous pemphigoid (7 (7.7%)), (6 (6.6%)). mean latency...
In this study, we compared the impact of health problems (HPs) on everyday activities and depressive symptoms between middle-aged older adults. We also examined what type source social interactions moderate noxious effects HPs. Longitudinal analyses data with 1,802 Japanese community-dwelling adults indicated that HPs were significantly related to (a) an increase in among (b) a decline The former was buffered by emotional family support, whereas latter instrumental support and, surprisingly,...
A decrease in the number of basophils peripheral blood, or basopenia, has been noted, reflecting activity chronic spontaneous urticaria (CSU). Infiltration into skin also reported, but mechanism basopenia CSU not clarified. The phenomenon during active phase was confirmed, and basophil numbers increased following symptom improvement 15 out 17 patients treated with omalizumab 13 antihistamines. Our examination by immunostaining revealed infiltration lesions, as previous reports, since most...
Cancer immunotherapy has highlighted the clinical relevance of enhancing anti-tumor response CD8+ T cells in several cancer types. Little is known, however, about involvement immune system extramammary Paget's disease (EMPD). We examined cytotoxicity and effector functions using paired samples peripheral blood tumors by flow cytometry. Expression levels perforin, granzyme B, IFN-g, TNF-a, IL-2 tumor-infiltrating lymphocytes (TILs) were significantly lower than those blood. Significantly...
Abstract Immune checkpoint inhibitors have improved the prognosis of advanced melanoma. Although anti–programmed death ligand‐1 ( PD ‐L1) is a well‐studied biomarker for response to death‐1 ‐1 therapy in melanoma, its clinical relevance remains unclear. It has been established that high expression indoleamine 2,3‐dioxygenase IDO ) correlated anti– CTLA ‐4 treatment However, it still unknown whether associated with In addition, acral and mucosal melanomas, which comprise great proportion all...
The assessment of facial symmetry, after mandibular reconstruction, currently relies on subjective esthetic by an evaluator. present study aimed to compare conventional with quantitative evaluation three-dimensional (3D) stereophotogrammetry cosmetic symmetry. This retrospective enrolled 20 patients who underwent reconstruction free fibula flap segmental resection between 2014 and 2018. Subjective assessments were performed seven clinicians at 6–12 months surgery. Simultaneously, lower face...