A5024608308- Dermatology and Skin Diseases
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Allergic Rhinitis and Sensitization
- T-cell and B-cell Immunology
- Asthma and respiratory diseases
- Cutaneous lymphoproliferative disorders research
- IL-33, ST2, and ILC Pathways
- Telomeres, Telomerase, and Senescence
- Urticaria and Related Conditions
- Cutaneous Melanoma Detection and Management
- Biotin and Related Studies
- Hematopoietic Stem Cell Transplantation
- Chemical Synthesis and Analysis
- Obesity and Health Practices
- Vascular Tumors and Angiosarcomas
- Clinical Reasoning and Diagnostic Skills
- Patient-Provider Communication in Healthcare
- Bee Products Chemical Analysis
- Cytomegalovirus and herpesvirus research
- Antimicrobial Peptides and Activities
- Autoimmune and Inflammatory Disorders Research
- Exercise and Physiological Responses
- Child Nutrition and Feeding Issues
Beiersdorf (Germany)
2021-2024
Kyoto University
2016-2021
University College London
2013-2016
Philipps University of Marburg
2016
Max Planck Institute for Human Development
2016
University of Konstanz
2016
Imperial College London
2009-2010
Amphibians are experiencing a panzootic of unprecedented proportions caused by the emergence Batrachochytrium dendrobatidis (Bd). However, all species not equally at risk infection, and is further modified environmental variables, specifically temperature. In order to understand how, when, hosts mount response Bd we analysed infection dynamics patterns gene expression in model amphibian Silurana (Xenopus) tropicalis. Mathematical modelling demonstrate existence temperature-dependent...
Although nivolumab is associated with a significant improvement in overall survival and progression-free survival, only 20 to 40% of patients experience long-term benefit. It therefore great interest identify predictive marker clinical benefit for nivolumab. To address this issue, the frequencies CD4+ T cell subsets (Treg, Th1, Th2, Th9, Th17 Th22), CD8+ cells, serum cytokine levels (IFNγ, IL-4, IL-9, IL-10, TGF-β) were assessed 46 melanoma. Eighteen responded nivolumab, other 28 did not. An...
Cutaneous angiosarcoma (CAS) is a malignant sarcoma with poor prognosis. Programmed cell death-1 (PD-1)/programmed ligand-1 (PD-L1) expression reflects antitumor immunity, and associated patient prognosis in various cancers. The purpose of this study to investigate the relationship between PD-1/PD-L1 CAS cases (n = 106) were immunohistochemically studied for PD-L1 PD-1 expression, correlation was analyzed. assessed by flow cytometry on three lines or without IFNγ stimulation. A total 30.2%...
T lymphocytes have been implicated in the pathogenesis of antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Patients with myeloperoxidase (MPO) antibody (ANCA) experience relapses less frequently than those proteinase 3 ANCA, suggesting greater immune regulation. This study was undertaken to investigate MPO-specific cell reactivity during disease remission and factors regulating their responsiveness.MPO-specific cells were quantified by enzyme-linked immunospot assay...
The cytokine IFN-α is secreted during viral infections and has been shown to inhibit telomerase activity accelerate T cell differentiation in vivo. However, the mechanism for this inhibition not clear. In study, we show that inhibits both transcription translation of human reverse transcriptase (hTERT), catalytic component telomerase, activated CD8(+) cells. This was associated with increased repressor hTERT E2 factor decreased activation NF-κB promotes transcription. However did affect...
Background. While dichotomous tasks and related cognitive strategies have been extensively researched in psychology, little is known about how primary care practitioners (general [GPs]) approach ill-defined or polychotomous valid useful their are. Objective. To investigate used by GPs for making a diagnosis. Methods. In cross-sectional study, we videotaped 282 consultations, irrespective of presenting complaint final Reflective interviews were performed with after each consultation....
A survey for enteric infections in 140 asymptomatic homosexual men who attended a community clinic revealed high prevalence of infection with Entamoeba histolytica (27.1 per cent) and Giardia lamblia (15.7 cent). In contrast, the elevated indirect hemagglutination (IHA) titers (greater than or equal to 1:128), which indicate invasive amebiasis, was low (5.7 Our findings suggest that only limited amount amebic disease is occurring this group men.
Immune checkpoints are essential for preventing immunopathology but can also obstruct anti-tumor immune responses. Recent medical advances in blocking these mechanisms have therefore opened promising avenues the treatment of cancer. Various antibodies targeting programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) now approved human use. This review summarizes properties PD-1 CTLA-4 physiological tumor settings, examines efficacy, side effects biomarkers...
Modelling atopic dermatitis (AD) in vitro is paramount to understand the disease pathophysiology and identify novel treatments. Previous studies have shown that Th2 cytokines IL-4 IL-13 induce AD-like features keratinocytes vitro. However, it has not been systematically researched whether addition of cells, their supernatants or a 3D structure superior model AD compared simple 2D cell culture with cytokines. For first time, we investigated what option most closely resembles vivo based on...
Abstract The discovery of bioactive natural products lies at the forefront human medicine. continued these molecules is imperative in fight against infection and disease. While have historically dominated drug market, recent years has slowed significantly, partly due to limitations current methodologies. This work demonstrates a new workflow, Deuterium Adduct Bioactivity Screening (DABS), which pairs untargeted isotope labeling with whole cell binding assays for product discovery. DABS was...
Background: Modelling atopic dermatitis (AD) in vitro is paramount to understand the disease pathophysiology and identify novel treatments. Previous studies have shown that Th2 cytokines IL-4 IL-13 induce AD-like features keratinocytes . However, it has not been systematically researched whether addition of cells, their supernatants or a 3D structure are superior model AD compared simple 2D cell culture with cytokines. Methods: For first time, we investigated what option most closely...