A5057445390- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroblastoma Research and Treatments
- Ferroptosis and cancer prognosis
- interferon and immune responses
- Immune Response and Inflammation
- Adipokines, Inflammation, and Metabolic Diseases
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Phagocytosis and Immune Regulation
- Autophagy in Disease and Therapy
- Biochemical Acid Research Studies
- GDF15 and Related Biomarkers
- Tryptophan and brain disorders
Max Planck Institute of Biochemistry
2021-2023
Interleukin-4-induced-1 (IL4i1) is an amino acid oxidase secreted from immune cells. Recent observations have suggested that IL4i1 pro-tumorigenic via unknown mechanisms. As has homologs in snake venoms (L-amino oxidases [LAAO]), we used comparative approaches to gain insight into the mechanistic basis of how conserved regulate cell fate and function. Using mammalian expressed recombinant proteins, found venom LAAO kills cells hydrogen peroxide generation. By contrast, non-cytotoxic instead...
Inflammation induces macrophage histone lactylation uncoupled from arginine metabolism or M2 polarization.
Immune cells regulate tumor growth by mirroring their function as tissue repair organizers in normal tissues. To understand the different facets of immune-tumor collaboration through genetics, spatial transcriptomics, and immunologic manipulation with noninvasive, longitudinal imaging, we generated a penetrant double oncogene-driven autochthonous model neuroblastoma. Spatial transcriptomic analysis showed that CD4+ myeloid populations colocalized within parenchyma, while CD8+ T B were...
Anti-TNF therapies are a core anti-inflammatory approach for chronic diseases such as rheumatoid arthritis and Crohn’s Disease. Previously, we others found that TNF blocks the emergence function of alternative-activated or M2 macrophages involved in wound healing tissue-reparative functions. Conceivably, anti-TNF drugs could mediate their protective effects part by an altered balance macrophage activity. To understand mechanistic basis how regulates macrophages, used RNAseq, scRNAseq,...
Summary By mirroring their function as tissue repair organizers in normal tissues, immune cells regulate tumor growth. To understand the different facets of immune-tumor collaboration through genetics, spatial transcriptomics, and immunological manipulation with non-invasive, longitudinal imaging, we generated a penetrant double oncogene-driven autochthonous model neuroblastoma. Using transcriptomic analysis, co-localized CD4 + myeloid populations within parenchyma, while CD8 T B were...
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<div>Abstract<p>Immune cells regulate tumor growth by mirroring their function as tissue repair organizers in normal tissues. To understand the different facets of immune–tumor collaboration through genetics, spatial transcriptomics, and immunologic manipulation with noninvasive, longitudinal imaging, we generated a penetrant double oncogene–driven autochthonous model neuroblastoma. Spatial transcriptomic analysis showed that CD4<sup>+</sup> myeloid populations...
<div>Abstract<p>Immune cells regulate tumor growth by mirroring their function as tissue repair organizers in normal tissues. To understand the different facets of immune–tumor collaboration through genetics, spatial transcriptomics, and immunologic manipulation with noninvasive, longitudinal imaging, we generated a penetrant double oncogene–driven autochthonous model neuroblastoma. Spatial transcriptomic analysis showed that CD4<sup>+</sup> myeloid populations...