A5082312064- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- Genetics and Neurodevelopmental Disorders
- Statistical Methods in Clinical Trials
- Nutrition, Health and Food Behavior
- Gene expression and cancer classification
- Diverse Topics in Contemporary Research
- CRISPR and Genetic Engineering
- Genetics, Bioinformatics, and Biomedical Research
- Cytokine Signaling Pathways and Interactions
- Computational Drug Discovery Methods
- Technology and Data Analysis
- COVID-19 Clinical Research Studies
- Consumer Perception and Purchasing Behavior
- Education and Learning Interventions
- RNA Interference and Gene Delivery
- Pharmacological Effects of Natural Compounds
- Advanced Proteomics Techniques and Applications
- 3D Printing in Biomedical Research
- Bayesian Methods and Mixture Models
- Virus-based gene therapy research
- Bioinformatics and Genomic Networks
- Adrenal Hormones and Disorders
- Long-Term Effects of COVID-19
- Structural Load-Bearing Analysis
Konkuk University
2016-2022
Asan Medical Center
2018-2021
University of Ulsan
2014-2021
Ulsan College
2020-2021
Rutgers, The State University of New Jersey
2013-2021
Rutgers Cancer Institute of New Jersey
2020
Rutgers Sexual and Reproductive Health and Rights
2015
University of Michigan
2006-2010
CHA University
2005-2009
University of the Pacific
2008
Journal Article Variable selection in clustering via Dirichlet process mixture models Get access Sinae Kim, Kim Search for other works by this author on: Oxford Academic Google Scholar Mahlet G. Tadesse, Tadesse Marina Vannucci Biometrika, Volume 93, Issue 4, December 2006, Pages 877–893, https://doi.org/10.1093/biomet/93.4.877 Published: 01 2006
Several therapeutic agents have been assessed for the treatment of COVID-19, but few approaches proven efficacious. Because leukotriene receptor antagonists, such as montelukast shown to reduce both cytokine release and lung inflammation in preclinical models viral influenza acute respiratory distress syndrome, we hypothesized that therapy with could be used treat COVID-19. The objective this study was determine if would rate clinical deterioration measured by COVID-19 Ordinal Scale.We...
// Jaeyun Jung 1 , Chanjoo Yeom 2 Yeon-Sook Choi Sinae Kim EunJi Lee Min Ji Park Sang Wook Kang Sung Bae 1, Suhwan Chang Department of Biomedical Sciences, University Ulsan School Medicine, Seoul 138-736, Korea Asan Medical Center, Correspondence to: Chang, e-mail: suhwan.chang@amc.seoul.kr Keywords: oncogenic microRNA, miRNA inhibitor, sponge, breast cancer, pancreatic cancer Received: September 12, 2014 Accepted: July 11, 2015 ...
The establishment of new technology for genetic modification in human embryonic stem (ES) cell lines has raised great hopes achieving ground basic and clinical research. Recently, lentiviral vector been shown to be highly effective therefore could emerge as a popular tool ES modification. objectives this study were evaluate the efficiency promoters gene delivery systems mammalian cells, including mouse, monkey, human, construct efficient optimized conditions lentivirus-mediated transfection...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is a positive-sense single-stranded RNA (+ssRNA) that causes disease 2019 (COVID-19). The viral genome encodes twelve genes for replication and infection. third open reading frame the spike (S) gene glycoprotein interacting with specific cell surface receptor - angiotensin converting enzyme (ACE2) on host membrane. Most recent studies identified single point mutation in S gene. A leading to an amino acid substitution at codon 614...
Article Natural Plant Extracts as Novel Antiviral Candidates: Citrus extracts Mijeong Choi 1,†, Jihyeong Hwang 2,†, Kwango Han 1, Hyunjik Noh Byeongju Kang Taehwa Jeong Gyumin Haekyoung Lee Yuri Kim Hanbong Ryu Sinae 2, Heejun 3, and Saerok Shim 2,* 1 Biomedical Engineering Research Institute, 32 Dongguk-ro, Goyang-si 10326, Republic of Korea 2 The Institute YbdY Biotechnology, 83, Gasan digital 1-ro, Geumcheon-gu, Seoul 08589, 3 Kulf, 7, Sareung-ro 70 beon-gil, Namyangju-si, Gyeonggi-do...
We propose a Bayesian method for multiple hypothesis testing in random effects models that uses Dirichlet process (DP) priors nonparametric treatment of the distribution. consider general model formulation which accommodates variety conditions. A key feature our is use product spiked distributions, i.e., mixtures point-mass and continuous as centering distribution DP prior. Adopting these readily sharp null hypotheses allows estimation posterior probabilities such hypotheses. mixture...
Abstract We have developed a novel culture technique for human embryonic stem cells (hESCs) using porous membrane with feeder cells. The were seeded and attached to the bottom of and, subsequently, hESCs cultured on top membrane. This (PMT) allowed be successfully effectively efficiently separated from cell layer without enzyme treatment. being by PMT observed interact through pores membrane, where interaction was dependent pore size used. It also revealed that number hESC colonies depended...
Affinity purification followed by mass spectrometry (AP‐MS) has become a common approach for identifying protein–protein interactions (PPIs) and complexes. However, data analysis visualization often rely on generic approaches that do not take advantage of the quantitative nature AP‐MS. We present novel computational method, nested clustering , biclustering label‐free AP‐MS data. Our forms bait clusters based similarity interaction profiles identifies submatrices prey proteins showing...
Protein expression varies as a result of intricate regulation synthesis and degradation messenger RNAs (mRNA) proteins. Studies dynamic typically rely on time-course data sets mRNA protein expression, yet there are no statistical methods that integrate these multiomics deconvolute individual regulatory processes gene control underlying the observed concentration changes. To address this challenge, we developed Expression Control Analysis (PECA), method to quantitatively dissect variation...
Cytokines are significantly associated with the homeostasis of immune responses in health and disease. Interleukin-32 (IL-32) is a cytokine originally discovered natural killer cell transcript 4. IL-32 different disorders has been described terms pathogenesis progression diseases. Clinical studies have investigated under various conditions, such as viral infection, autoimmune diseases, inflammatory certain types cancer, vascular disease, pulmonary The high expression was identified tissues...
Abstract Background Several therapeutic agents have been assessed for the treatment of COVID-19, but few approaches proven efficacious. Because leukotriene receptor antagonists such as montelukast shown to reduce both cytokine release and lung inflammation in preclinical models viral influenza acute respiratory distress syndrome, we hypothesized that therapy with would clinical deterioration measured by COVID-19 Ordinal Scale. Methods We performed a retrospective analysis confirmed...
It has been reported that fatty acid binding proteins (FABPs) do not act only as intracellular mediators of lipid responses but also have extracellular functions. This study aimed to investigate whether liver type (L)-FABP a biological activity and determined serum L-FABP levels in patients with end-stage renal disease (ESRD). We isolated complementary deoxyribonucleic (cDNA) from the Huh7 human hepatocarcinoma cell line expressed recombinant protein Escherichia coli. A549 lung carcinoma...
BRCA1/2 mutations account for only a small fraction of homologous recombination (HR) deficiency (HRD) cases. Recently developed genomic HRD (gHRD) tests suffer confounding factors that cause low precision in predicting samples will respond to PARP inhibitors and DNA damaging agents. Here we present molecular clinical evidence transcriptional (tHRD) is based on aberrant transcript usage (aTU) minor isoforms. Specifically, increased TU nonfunctional isoforms repair genes was prevalent breast...
The induction of interleukin (IL)-32 in bone marrow (BM) inflammation is crucial graft versus host disease (GvHD) that a common side effect allogeneic BM transplantation.Clinical trials on a-1 antitrypsin (AAT) patients with GvHD are based the preliminary human and mouse studies AAT reducing severity GvHD.Proteinase 3 (PR3) an IL-32-binding protein was isolated from urine.IL-32 primarily induces inflammatory cytokines myeloid cells, probably due to PR3 expression membrane lineage cells.The...