A5043386594- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- RNA regulation and disease
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- vaccines and immunoinformatics approaches
- Glycosylation and Glycoproteins Research
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Clusterin in disease pathology
- S100 Proteins and Annexins
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Galectins and Cancer Biology
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
Asan Medical Center
2020-2023
Ulsan College
2020-2023
Korea University
2023
University of Ulsan
2015-2023
// Jaeyun Jung 1 , Chanjoo Yeom 2 Yeon-Sook Choi Sinae Kim EunJi Lee Min Ji Park Sang Wook Kang Sung Bae 1, Suhwan Chang Department of Biomedical Sciences, University Ulsan School Medicine, Seoul 138-736, Korea Asan Medical Center, Correspondence to: Chang, e-mail: suhwan.chang@amc.seoul.kr Keywords: oncogenic microRNA, miRNA inhibitor, sponge, breast cancer, pancreatic cancer Received: September 12, 2014 Accepted: July 11, 2015 ...
ADAR (adenosine deaminase acting on RNA) catalyzes the deamination of adenosine to generate inosine, through its binding double-stranded RNA (dsRNA), a phenomenon known as editing. One functions ADAR1 is suppressing type I interferon (IFN) response, but mechanism in gastric cancer not clearly understood. We analyzed changes editing and IFN signaling ADAR1-depleted cells, clarify how regulates signaling. Interestingly, we observed dramatic increase protein level signal transducer activator...
The major challenges in pancreatic ductal adenocarcinoma (PDAC) management are local or distant metastasis and limited targeted therapeutics to prevent it. To identify a druggable target tumor secretome explore its therapeutic intervention, we performed liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomic analysis of tumors obtained from patient-derived xenograft model PDAC. Galectin-3 binding protein (Gal-3BP) is identified as highly secreted protein, overexpression...
Deamination of adenine or cytosine in RNA, called RNA editing, is a constitutively active and common modification.The primary role editing tagging right after its synthesis so that the endogenous recognized as self distinguished from exogenous such viral RNA.In addition to this function, direct indirect effects on gene expression can be utilized cancer where high level activity persists.This report identified actin-related protein 2/3 complex inhibitor (ARPIN) target ADAR1 breast cells.Our...
BRCA1/2 mutations account for only a small fraction of homologous recombination (HR) deficiency (HRD) cases. Recently developed genomic HRD (gHRD) tests suffer confounding factors that cause low precision in predicting samples will respond to PARP inhibitors and DNA damaging agents. Here we present molecular clinical evidence transcriptional (tHRD) is based on aberrant transcript usage (aTU) minor isoforms. Specifically, increased TU nonfunctional isoforms repair genes was prevalent breast...
Abstract Background Systematic in vitro loss-of-function screens provide valuable resources that can facilitate the discovery of drugs targeting cancer vulnerabilities. Results We develop a deep learning-based method to predict tumor-specific vulnerabilities patient samples by leveraging wealth screening data. Acquired dependencies tumors are inferred cases which one allele is disrupted inactivating mutations or association with oncogenic mutations. Nucleocytoplasmic transport Ran GTPase...
Glioblastoma (GBM) is the most lethal brain cancer, causing inevitable deaths of patients owing to frequent relapses cancer stem cells (CSCs). The significance NOTCH signaling pathway in CSCs has been well recognized; however, there no NOTCH-selective treatment applicable with GBM. We recently reported that Jagged1 (JAG1), a ligand, drives receptor-independent via JAG1 intracellular domain (JICD1) as crucial signal renders CSC properties. Therefore, mechanisms regulating JICD1 should be...
Abstract Antitumor peptide vaccine is an alternative and attractive way to eradicate tumors by the aid of host immune system. The current development hampered several hurdles. These include heterogeneity tumor cells, applicable in vivo stability peptides, others. One major obstacles precise prediction cancer antigen, which can be loaded efficiently onto antigen presenting cells. We present here a neoantigen algorithm DeepNeo comprised DeepNeo-MHC DeepNeo-TCR, calculates antigenicity based on...
ABSTRACT BRCA1/2 mutations account for only a small fraction of homologous recombination (HR) deficiency (HRD) cases. Recently developed genomic HRD (gHRD) tests suffer confounding factors causing low precision in predicting samples that will respond to poly (ADP-ribose) polymerase (PARP) inhibitors and DNA damaging agents. Here, we present molecular evidence clinical utility transcriptional (tHRD) is based on aberrant transcript usage (TU) minor isoforms. Specifically, increased TU...