A5101959605- TGF-β signaling in diseases
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- S100 Proteins and Annexins
- Mitochondrial Function and Pathology
- Migraine and Headache Studies
- Virus-based gene therapy research
- Cytokine Signaling Pathways and Interactions
- Genetic Neurodegenerative Diseases
- Neurogenetic and Muscular Disorders Research
- Cancer-related gene regulation
- Air Quality Monitoring and Forecasting
- Cell Adhesion Molecules Research
- Clusterin in disease pathology
- RNA Research and Splicing
- Climate Change and Health Impacts
- Myasthenia Gravis and Thymoma
- Developmental Biology and Gene Regulation
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Parkinson's Disease and Spinal Disorders
- Glioma Diagnosis and Treatment
- Connective Tissue Growth Factor Research
- Trigeminal Neuralgia and Treatments
Inje University Haeundae Paik Hospital
2023-2024
Korea University
2021-2024
Seoul National University
2006-2019
Ajou University
2006
Sungkyunkwan University
2006
Abstract Although bevacizumab (BVZ), a representative drug for anti-angiogenesis therapy (AAT), is used as first-line treatment patients with glioblastoma (GBM), its efficacy notably limited. Whereas several mechanisms have been proposed to explain the acquisition of AAT resistance, specific underlying yet be sufficiently ascertained. Here, we established that inhibitor differentiation 1 (ID1) high /activin A cell confers resistance BVZ. The bipotent effect activin during active phase was...
Abstract Jagged1 (JAG1) is a Notch ligand that correlates with tumor progression. Not limited to its function as ligand, JAG1 can be cleaved, and intracellular domain translocates the nucleus, where it functions transcriptional cofactor. Previously, we showed (JICD1) forms protein complex DDX17/SMAD3/TGIF2. However, molecular mechanisms underlying JICD1-mediated aggressiveness remains unclear. Here, demonstrate JICD1 enhances invasive phenotypes of glioblastoma cells by transcriptionally...
The oncogenic role of nuclear LIM domain only 2 (LMO2) as a transcriptional regulator is well established, but its function in the cytoplasm largely unknown. Here, we identified LMO2 cytoplasmic activator for signal transducer and transcription 3 (STAT3) signaling glioma stem cells (GSCs) through biochemical bioinformatics analyses. increases STAT3 phosphorylation by interacting with glycoprotein 130 (gp130) Janus kinases (JAKs). LMO2-driven activation requires LDB1 protein leads to...
Alternative cancer models that are close to humans required create more valuable preclinical results during oncology studies. Here, a new onco-pig model via developing CRISPR-Cas9-based Conditional Polycistronic gene expression Cassette (CRI-CPC) system control the tumor inducing simian virus 40 large T antigen (SV40LT) and oncogenic HRASG12V . After conducting somatic cell nuclear transfer (SCNT), transgenic embryos were transplanted into surrogate mothers five male piglets born. Umbilical...
Glioblastoma (GBM) is the most lethal brain cancer, causing inevitable deaths of patients owing to frequent relapses cancer stem cells (CSCs). The significance NOTCH signaling pathway in CSCs has been well recognized; however, there no NOTCH-selective treatment applicable with GBM. We recently reported that Jagged1 (JAG1), a ligand, drives receptor-independent via JAG1 intracellular domain (JICD1) as crucial signal renders CSC properties. Therefore, mechanisms regulating JICD1 should be...
OPS 13: Heat, cold and mortality, Room 117, Floor 1, August 26, 2019, 1:30 PM - 3:00 Background/Aim: Recent studies showed that temperature variability is a risk factor for human mortality. Some also reported high temperature, demographic characteristics (e.g., age structure), regional climate modified the association between However comprehensive potential modifiers in community-scale have not been fully discussed. Investigating may contribute to establishing better public health...
Abstract Jagged1 (JAG1) is a Notch ligand that contact-dependently activates receptors and regulates cancer progression. The JAG1 intracellular domain (JICD1) generated from JAG1, such as the formation of NOTCH1 (NICD1), however, role JICD1 in tumorigenicity has not been comprehensively elucidated. Herein, we revealed induced astrocytes to acquire several stem cell properties, including tumor formation, invasiveness, stemness, resistance chemotherapy radiotherapy. transcriptome,...
Ataxia is presented by various etiologies, including acquired, genetic and degenerative disorders. Although hereditary ataxia suspected when typical symptom of with concurrent identified, it sometimes difficult to diagnose without test. Clinically, next generation sequencing technology has been developed widely used for diagnosis disease. Hereby, we experienced cases genetically confirmed <i>OPA1</i> mutation, which are clinical manifestations ataxic gait decreased visual acuity.
Background: We aimed to identify any differences in the structural covariance network based on volume and those functional cerebral blood flow between ipsilateral contralateral hemispheres of pain patients with episodic migraine without aura.Methods: prospectively enrolled 27 aura, all whom had unilateral pain. defined hemisphere as side measured volumes three-dimensional T1-weighted images using arterial spin labeling magnetic resonance imaging. then analyzed graph theory. Results: There...
P-589 Introduction: Estimation of inhalation rate is essential for the assessment uptake airborne pollutants in population. Since heart (HR) and ventilation (VR) are closely correlated, estimated from measurements over days. However, validity estimating equation widely varied, especially adolescents younger adults. This study was conducted to evaluate methods estimation normal Korean adults teenagers. Methods: We studied 51 (26 males 25 females) volunteers 15–47 years age. Test protocol...