A5002729713- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Systemic Sclerosis and Related Diseases
- Parkinson's Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Fibroblast Growth Factor Research
- Biotin and Related Studies
- Diabetes and associated disorders
- Immunotherapy and Immune Responses
- Hippo pathway signaling and YAP/TAZ
- Dermatologic Treatments and Research
- Sarcoma Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- Phagocytosis and Immune Regulation
- Gene Regulatory Network Analysis
- MicroRNA in disease regulation
- Mast cells and histamine
- Bioinformatics and Genomic Networks
- Pulmonary Hypertension Research and Treatments
- vaccines and immunoinformatics approaches
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Histiocytic Disorders and Treatments
Lund University
2014-2023
Tampere University Hospital
2009
Tampere University
2009
Here, we examine the cellular changes triggered by tumor necrosis factor alpha (TNF-α) and different alpha-synuclein (αSYN) species in astrocytes derived from induced pluripotent stem cells. Human treated with TNF-α display a strong reactive pro-inflammatory phenotype upregulation of gene networks, activation nuclear κB (NF-κB) pathway, release cytokines, whereas those high-molecular-weight αSYN fibrils acquire antigen (cross)-presenting major histocompatibility complex (MHC) genes increased...
SignificanceOur results demonstrate the existence of early cellular pathways and network alterations in oligodendrocytes alpha-synucleinopathies Parkinson's disease multiple system atrophy. They further reveal involvement an immune component triggered by alpha-synuclein protein, as well a connection between (epi)genetic changes reactivity The knowledge generated this study could be used to devise novel therapeutic approaches treat synucleinopathies.
The glutamate transporter 1 (GLT1) is upregulated during astrocyte development and maturation in vivo vital for function. Yet it expressed at low levels by most cultured astrocytes. We previously showed that of human mouse stem cell-derived astrocytes - including functional uptake could be enhanced fibroblast growth factor (FGF)1 or FGF2. Here, we examined the specificity mechanism action FGF2 other FGF family members, as well neurotrophic differentiation factors, on embryonic found some...
Objective. To evaluate the expression profiles of cell-free plasma miRNAs in SSc and to characterize their correlation with disease subgroups (lcSSc dcSSc) autoantibody profiles.
SSc-associated pulmonary arterial hypertension (SSc-APAH) is a late but devastating complication of SSc. Early identification SSc-APAH may improve survival. We examined the role circulating miRNAs in SSc-APAH.Using quantitative RT-PCR abundance mature plasma was determined 85 female patients with ACA-positive lcSSc. Twenty-two had SSc-APAH. Sixty-three SSc controls without PAH were matched for disease duration. Forty-six selected miRNA levels correlated clinical data. Longitudinal samples...
Somatic variations are frequent and important drivers in cancers. Amino acid substitutions can yield neoantigens that detected by the immune system. Neoantigens lead to response tumor rejection. Although neoantigen load occurrence have been widely studied, a detailed pan-cancer analysis of characterization neoepitopes is missing. We investigated proteome-wide amino 8-, 9-, 10-, 11-mer peptides 30 cancer types with NetMHC 4.0 software. 11,316,078 (0.24%) predicted were highly likely...
Most neoplasia-associated gene fusions are formed through the fusion of 5'-part one with 3'-part another. We here describe a unique mechanism, by which part KMT2A an insertion replaces YAP1 gene. The resulting YAP1::KMT2A::YAP1 (YKY) was verified RT-PCR in three cases sarcoma morphologically resembling sclerosing epithelioid fibrosarcoma (SEF-like sarcoma). In all cases, portion (exons 4/5-6) encoding CXXC domain inserted between exon 4/5 and 8/9 YAP1. sequence from thus replaced exons 5/6-8...
Data-driven studies on the dynamics of reconstructed protein-protein interaction (PPI) networks facilitate investigation and identification proteins important for particular processes or diseases reduces time costs experimental verification. Modeling very large PPI is computationally costly.To circumvent this problem, we created a link-weighted human immunome interactome performed filtering. We weighed links using jackknife gene expression correlation integrated, course data. Statistical...
Primary immunodeficiencies (PIDs) form a large and heterogeneous group of mainly rare disorders that affect the immune system. T-cell deficiencies account for about one-tenth PIDs, most them being monogenic. Apart from genetic clinical information, lots other data are available PID proteins genes, including functions interactions. Thus, it is possible to perform systems biology studies on effects PIDs physiology response. To achieve this, we reconstructed network model based literature...
Primary immunodeficiencies (PIDs) is a group of over 300 hereditary, heterogeneous and mainly rare disorders that affect the immune system. Various aspects system PID proteins genes have been investigated facilitate systems biological studies effects PIDs on B cell physiology response. We reconstructed network model based data for core receptor activation response processes performed semi-quantitative dynamic simulations normal failure modes. The results several knock-out correspond to...