A5034126452- Child and Adolescent Psychosocial and Emotional Development
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Eating Disorders and Behaviors
- Epigenetics and DNA Methylation
- Neuropeptides and Animal Physiology
- Family Caregiving in Mental Illness
- Mental Health Research Topics
- Obsessive-Compulsive Spectrum Disorders
- Olfactory and Sensory Function Studies
- Attention Deficit Hyperactivity Disorder
- Hormonal Regulation and Hypertension
- Bipolar Disorder and Treatment
- GABA and Rice Research
- Attachment and Relationship Dynamics
- Intergenerational Family Dynamics and Caregiving
- Sleep and Wakefulness Research
- Tryptophan and brain disorders
- Reading and Literacy Development
- Palliative Care and End-of-Life Issues
- Neurotransmitter Receptor Influence on Behavior
- Regulation of Appetite and Obesity
- Language Development and Disorders
- Mental Health Treatment and Access
Dornier (Germany)
2012-2023
Dornier Flugzeugwerke (Germany)
2012-2020
University of Münster
2010-2015
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2013
The monoamine oxidase A (MAOA) gene has been suggested as a prime candidate in the pathogenesis of panic disorder. In present study, DNA methylation patterns MAOA regulatory and exon 1/intron 1 region were investigated for association with disorder particular attention to possible effects gender environmental factors. Sixty-five patients (44 females, 21 males) 65 healthy controls analysed status at 42 CpG sites via direct sequencing sodium bisulfate treated extracted from blood cells....
Abstract The plasticity of the adult memory network for integrating novel word forms (lexemes) was investigated with whole-head magnetoencephalography (MEG). We showed that spoken an (artificial) foreign language are integrated rapidly and successfully into existing lexical conceptual networks. new lexemes were learned in untutored way, by pairing them frequently one particular object (and thus meaning), infrequently 10 other objects (learned set). Other encountered just as often, but paired...
The pathogenesis of anxiety disorders is considered to be multifactorial with a complex interaction genetic factors and individual environmental factors. Therefore, the aim this study was examine gene‐by‐environment interactions genes coding for catechol‐ O ‐methyltransferase ( COMT ) monoamine oxidase A MAOA life events on measures related anxiety. sample healthy subjects N = 782; thereof 531 women; mean age M 24.79, SD 6.02) genotyped rs4680 ‐ uVNTR (upstream variable number tandem...
Genetic factors and environmental are assumed to interactively influence the pathogenesis of anxiety disorders. Thus, a gene-environment interaction (G × E) study was conducted with respect sensitivity (AS) as promising intermediate phenotype disorders.Healthy subjects (N = 363) were assessed for AS, childhood maltreatment (Childhood Trauma Questionnaire), genotyped functional serotonin transporter gene variants (5-HTTLPR/5-HTT rs25531). The genetic variables on AS its subdimensions...
Objectives. The pathogenesis of anxiety is assumed to be interactively influenced by genetic and environmental factors. Thus, a gene–environment interaction (G × E) study the neuropeptide S receptor gene (NPSR) A/T polymorphism (rs324981) life events was conducted with respect sensitivity (AS) as an intermediate phenotype disorders. Methods. A sample 475 healthy German subjects genotyped for NPSR assessed AS, childhood maltreatment (CTQ) recent (LTE). Influences on AS its subdimensions were...
Accumulating evidence from mouse models points to the G protein‐coupled receptor RGS2 (regulator of G‐protein signaling 2) as a promising candidate gene for anxiety in humans. Recently, polymorphisms were found be associated with various disorders, e.g., rs4606 panic disorder (PD), but other findings have been negative or inconsistent concerning respective risk allele. To further examine role pathogenesis PD, we genotyped and five additional tag single nucleotide (SNPs; rs16834831,...
Background Panic disorder is common (5% prevalence) and females are twice as likely to be affected males. The heritable component of panic estimated at 48%. Glutamic acid dehydrogenase GAD1, the key enzyme for synthesis inhibitory anxiolytic neurotransmitter GABA, supposed influence various mental disorders, including mood anxiety disorders. In a recent association study in depression, which highly comorbid with disorder, GAD1 risk allele associations were restricted females....
The etiology of emotion-related disorders such as anxiety or affective is considered to be complex with an interaction biological and environmental factors. Particular evidence has accumulated for alterations in the dopaminergic noradrenergic system – partly conferred by catechol-O-methyltransferase (COMT) gene variation adenosinergic well early life trauma constitute risk factors those conditions. Applying a multi-level approach, sample 95 healthy adults, we investigated effects functional...
Impairments in facial emotion recognition are an underlying factor of deficits regulation and interpersonal difficulties mental disorders evident eating (EDs).We used a computerized psychophysical paradigm to manipulate parametrically the quantity signal expressions (QUEST threshold seeking algorithm). This was measure 308 adult women (anorexia nervosa [n = 61], bulimia 58], healthy controls 130], mixed [mixed, n 59]). The M (SD) age 22.84 (3.90) years. aims were establish thresholds...
Background Difficulties in emotion regulation have been related to psychological and physiological stress responses such as lower mood parasympathetic activation (HF-HRV) under resting condition, but evidence on the potential link hypothalamic-pituitary-adrenal (HPA) axis functioning during a task is still scarce. The aim of study was investigate young women when confronted daily stressor exposure thin ideals understand role correlates self-reported trait-like difficulties (ERD). Methods...
Abstract The current study intends to investigate whether the therapeutic process is impeded by stigma and how develops over course of cognitive behavioural psychotherapy treatment. Sixty German inpatients were asked on a weekly basis about two facets stigma: self‐stigma perceived public stigma. That information was linked additional as well outcome variables (therapeutic engagement, working alliance, depressive, general psychological symptoms). Both decreased psychotherapy, but only...
This study examined the consequences of media exposure to thin ideals compared pictures landscapes in healthy young women and with eating mixed mental disorders investigated whether appearance-related cognitive factors distortions moderate effects. Two hundred seventy-five a multisite laboratory trial (174 in- or outpatients 101 women; Mage 22.87 years, SD = 3.94) were exposed either landscape guided through vivid imagery these thereafter. Changes body image dissatisfaction, mood, behavior,...
This descriptive study examined patient characteristics, treatment and short-term outcomes among patients with Anorexia Nervosa (AN) Bulimia (BN) in routine clinical care. Results for receiving full-time were contrasted results ambulatory treatment. Data of a trial including 116 female (18–35 years) diagnosed AN or BN subjected to secondary analyses. Patients voluntarily admitted one nine facilities Germany Switzerland. received cognitive-behavioral interventions accordance the national...
Inpatients diagnosed with major depression that had lost a loved person were asked about loss-related variables and symptoms of complicated grief (CG).CG was assessed by the Inventory Complicated Grief (ICG-R). 14.2% n = 127 individuals unipolar met criteria for CG. Depressive patients CG compared to those without lower educational level; reported higher burden at time loss, during survey year after loss; significant different closeness within relationships deceased; loss more recently.An...
Introduction The monoamine oxidase A ( MAO-A ) gene has been suggested as a vulnerability in the pathogenesis of panic disorder. Objectives Epigenetic processes such methylation critically influencing regulation and mediating adaptation to environmental factors have so far not investigated Aims Thus, present study DNA patterns regulatory exon1/intron1 region were for association with Methods Sixty-five patients disorder (m = 21, f = 44) 65 healthy controls analyzed status at 42 CpG sites via...
Theoretischer Hintergrund: Mit Fragebögen erfasste Depressions- und Angstwerte sind häufig hoch korreliert. Nach dem Tripartite Modell von Clark Watson (1991) ist diese Kovariation auf die gemeinsame Komponente negativer Affekt zurückzuführen. Eine bessere Differenzierung depressiver ängstlicher Symptome sei über den depressionsspezifischen geringen positiven das angstspezifische physiologische Hyperarousal möglich. Fragestellung: Ziel dieser Studie Überprüfung dieses Modells Bestimmung...
The glutamate decarboxylase (GAD67/65; GAD1/GAD2) as the rate-limiting enzyme in gamma-aminobutyric acid (GABA) synthesis has been suggested a prime candidate pathogenesis of anxiety disorders. In present study, DNA methylation GAD1/2 gene regulatory regions was investigated for association with panic disorder particular attention to possible effects environmental factors. Sixty-five patients (f=44, m=21) and 65 matched healthy controls were analyzed status at 40 GAD1 10 GAD2 CpG sites via...