A5024559499- Calcium signaling and nucleotide metabolism
- Cellular transport and secretion
- Lysosomal Storage Disorders Research
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Neurosurgical Procedures and Complications
- Hematopoietic Stem Cell Transplantation
- Parvovirus B19 Infection Studies
- Ethics and bioethics in healthcare
- Vector-Borne Animal Diseases
- Global Public Health Policies and Epidemiology
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Hematological disorders and diagnostics
- COVID-19 Clinical Research Studies
- Public Health Policies and Education
- Health disparities and outcomes
- Healthcare Systems and Reforms
Costa Rican Department of Social Security
2022
Commonly known as Batten disease, the neuronal ceroid lipofuscinoses (NCLs) are a genetically heterogeneous group of rare pediatric lysosomal storage disorders characterized by intracellular accumulation autofluorescent material (known lipofuscin), progressive neurodegeneration, and neurological symptoms. In 2002, disease-causing NCL mutation in CLN6 gene was identified (c.214G > T) Costa Rican population, but frequency this among local disease patients remains incompletely characterized, do...
COVID-19 is a disease caused by the novel Coronavirus SARS-CoV-2 causing an acute respiratory that can eventually lead to severe syndrome (SARS). An exacerbated inflammatory response characteristic of infection, which leads cytokine release also known as storm associated with severity disease. Considering importance this event in immunopathology COVID-19, study analyses levels hospitalized patients identify profiles and mortality. Using machine learning approach, 3 clusters were created...
Background Aplastic anemia (AA) is a rare and heterogeneous hematological disorder defined as pancytopenia with hypocellular bone marrow in the absence of abnormal infiltration or medullary fibrosis. Various causes AA have been identified, such autoimmune factors, injuries, viral infections, genetic disorders. The symptoms are directly linked to most common fatigue, recurrent bleeding problems. treatment varies according severity disease includes immunosuppressive therapies transplantation....
Objetivo: este estudio tuvo como objetivo describir la incidencia y analizar las principales características demográficas, epidemiológicas, clínicas, de diagnóstico tratamiento; así presencia factores riesgo pronósticos conocidos en pacientes costarricenses con e sclerosis múltiple, atendidos tres hospitales, que participaron el internacional denominado ENHANCE. Métodos: fue naturaleza observacional, se analizaron forma retrospectiva los registros médicos mayores 18 años diagnosticados...
Presente mayoritariamente en el sexo masculino y con diagnóstico durante la quinta década de vida, hepatocarcinoma constituye malignidad hepática más frecuente mayor mortalidad. Su desarrollo se relaciona presencia infecciones por virus Hepatitis B C, consumo alcohol prevalencia enfermedades metabólicas. La presente investigación tuvo como objetivo describir incidencia patología, seroprevalencia Hepatitis, compromiso hepático al supervivencia global los principales hospitales Seguridad...
La creciente incidencia de diabetes mellitus tipo 1 y 2, así como la inefectividad terapéutica actual en pacientes difícil control, ha llevado a necesidad ampliar disponibilidad opciones tratamiento para este sector poblacional, buscando novedosos tratamientos que brinden resultados corto mediano plazo un menor número complicaciones secundarias. Es por esto lo través historia se han desarrollado múltiples intentos trasplantar el órgano encargado contrarrestar los elevados niveles glucosa...
Abstract Background: Commonly known as Batten disease, the neuronal ceroid lipofuscinoses (NCLs) are a genetically heterogeneous group of rare pediatric lysosomal storage disorders characterized by intracellular accumulation autofluorescent material (known lipofuscin), progressive neurodegeneration, and neurological symptoms. In 2002, disease-causing NCL mutation in CLN6 gene was identified (c.214G>T) Costa Rican population, but frequency this among local disease patients remains...