A5058350830- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Porphyrin Metabolism and Disorders
- Childhood Cancer Survivors' Quality of Life
- Folate and B Vitamins Research
- Chronic Myeloid Leukemia Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Methemoglobinemia and Tumor Lysis Syndrome
- Chromium effects and bioremediation
- Drug Transport and Resistance Mechanisms
- Alcoholism and Thiamine Deficiency
- Aluminum toxicity and tolerance in plants and animals
- Nutrition and Health in Aging
- Drug-Induced Hepatotoxicity and Protection
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Hepatitis B Virus Studies
- Lymphoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Blood donation and transfusion practices
- Chronic Lymphocytic Leukemia Research
- Neuroblastoma Research and Treatments
- Pharmacogenetics and Drug Metabolism
Royal London Hospital
2021-2024
Barts Health NHS Trust
2021-2023
University Hospital Southampton NHS Foundation Trust
2020-2021
Great Ormond Street Hospital
2018-2020
University College London
2018-2020
Pediatric Oncology Group
2020
Hospital for Sick Children
2019
Palmetto Hematology Oncology
2019
King George's Medical University
1993-2014
Indian Institute of Toxicology Research
1982-1994
Abstract: Thiamine, ascorbic acid and their combination were investigated for ability to prevent or treat the experimental lead intoxication in rats. The of two vitamins was most effective reducing induced inhibition activity blood δ‐aminolevulinic dehydratase, elevation level zinc protoporphyrin urinary excretion uptake blood, liver kidney. combined treatment post exposure also restoring biochemical alterations mobilizing from tissues. order effectiveness was, thiamine + < thiamine....
Thiamine, zinc or their combination given through gastric gavage were investigated for ability to prevent treat experimental lead toxicity in rats. Simultaneous dietary supplementation with thiamine plus was found be the most effective way of reducing lead-induced inhibition delta-aminolevulinic acid dehydratase activity blood, urinary, excretion and accumulation liver kidney. Prevention more than post-lead exposure treatment which may due mainly decrease absorption gastro-intestinal tract...
Key Points Children with PCNSL and no immunodeficiency have a good outcome when treated by histological subtype–driven radiation-free protocol. New treatment guidelines are needed for in children adolescents an underlying immunodeficiency.
Abstract: The supplementation of vitamin‐B complex reduces lead intoxication. With a view to identify the components responsible for such protection, riboflavin, calcium pentothenate, pyridoxine, nicotinamide, folic acid and cyanocobalamine were investigated their ability, influence on efficacy disodium versenate (Na 2 CaEDTA), enhance urinary excretion lead, mobilize tissue restore induced biological alterations in intoxicated rats. Folic pyridoxine besides thiamine may be factors...
The effects of the daily administration aluminium (25 mg kg-1, orally), ethanol (10% v/v, in drinking water) or both to adult rats, for 6 weeks, on amount present tissues and functioning brain biogenic amines, hepatic serum transaminases some haematopoietic variables were investigated. Ethanol alone was seen inhibit activity delta-aminolevulinic acid dehydratase (ALAD), while elevated blood ALAD. However, combined produced a more pronounced inhibition ALAD glutamic pyruvic transaminase (GPT)...
Congenital Acute Myeloid leukemia (CAML) is a rare diagnosed within the first 28 days of life. Dismal survival rates approximately 25% at two years from diagnosis have not improved despite multiple treatment protocols, and there lacks international consensus for optimal management these vulnerable patients. We report retrospective analysis our fifteen-year experience large UK tertiary pediatric center, focusing on modalities outcomes, including late therapeutic toxicities. To knowledge, this...
Abstract Background The adverse influence of undernutrition in children with cancer may be remediated by early nutritional intervention. This study assessed the efficacy ready‐to‐use therapeutic food (RUTF) improving status and reducing treatment‐related toxicities (TRTs) such children. Methods In a randomized controlled phase‐3 open‐label trial, severely moderately undernourished were 1:1 to receive standard therapy (SNT) or SNT+RUTF for 6 weeks. primary outcome (weight gain >10%)...
One-thousand-and-sixty-five pregnant mothers among a rural population of 30,000 in Uttar Pradesh were followed for 1 year. A still birth rate 26.1 and perinatal mortality 121.1 per thousand births registered. Early neonatal was found to be 97.4 live births. Twenty cent the women identified with high risk factors. Inadequate or no antenatal care, bad obstetric history, prolonged labour attributed 13, 20, 27 risk, respectively, respective relative 2.23, 3.1, 4.09 times. These three factors...