A5005398808- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Zebrafish Biomedical Research Applications
- Mesenchymal stem cell research
- Spinal Cord Injury Research
- Tryptophan and brain disorders
- Gut microbiota and health
- Neuropeptides and Animal Physiology
- Berberine and alkaloids research
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Pluripotent Stem Cells Research
- Bone and Joint Diseases
- Biochemical Analysis and Sensing Techniques
- Hematopoietic Stem Cell Transplantation
- Genetic factors in colorectal cancer
- MicroRNA in disease regulation
- Parkinson's Disease Mechanisms and Treatments
- Advanced biosensing and bioanalysis techniques
- Mast cells and histamine
- Stress Responses and Cortisol
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Olfactory and Sensory Function Studies
- RNA Interference and Gene Delivery
- Biotin and Related Studies
Jiangnan University
2017-2024
First Affiliated Hospital of Soochow University
2021
Soochow University
2021
Nanjing Drum Tower Hospital
2015-2016
University of Utah
1994
University of Virginia
1992
Accumulative studies suggest that inflammatory bowel disease (IBD) may cause multiple central nervous system (CNS) pathologies. Studies have found indoleamine-2,3-dioxygenase (IDO, rate-limiting enzyme of the kynurenine (Kyn) pathway) deficient mice were protected from endotoxin induced cognitive impairment, and Kyn administration memory deficits in both control IDO-deficient mice. However, there is no investigation brain pathway IBD, thus we investigated whether dextran sulfate sodium...
The ancestry of dopaminergic (DA) neurons in the Xenopus laevis hypothalamus was investigated by combining intracellular lineage dye injections 16- and 32-cell blastomeres with immunofluorescent detection tyrosine hydroxylase at tadpole stages. At these stages, DA comprise a discrete nucleus that contains from 22 to 45 cells on each side [mean = 32.6 +/- 6.6 (SD)]. descends only four 16-cell blastomeres. two dorsal midline (D1.1) are major progenitors, all embryos studied they contributed...
Parkinson’s disease (PD) is characterized not only by motor symptoms but also non-motor dysfunctions, such as olfactory impairment; the cause fully understood. Our study suggests that neuronal loss and inflammation in brain regions along pathway, bulb (OB) piriform cortex (PC), may contribute to dysfunction PD mice, which might be related downregulation of trace amine-associated receptor 1 (TAAR1) these areas. In striatum, although a decrease mRNA level, protein TAAR1 was detected,...
<h3>Background</h3> Umbilical cord (UC)-derived mesenchymal stem cells (MSCs) have been confirmed to exert therapeutic effects on systemic lupus erythematosus (SLE). Deficiency in SLE macrophages exhibits excessive activation and inefficient clearance of self nuclear antigens. However, whether the benefit effect UCMSCs was mediated by regulatory remains be elucidated. <h3>Objectives</h3> We aim explore could educate macrophage become a kind alternatively activated increase its phagocytic...
<h3>Background</h3> Follicular helper T (Tfh) cells have been implicated in the pathogenesis of autoimmune diseases. Human umbilical cord mesenchymal stem cell (hUC-MSC). Transplantation could alleviate disease progression both lupus mice and patients. However, mechanism is largely unknown. <h3>Objectives</h3> The objective this study was to explore modulatory effects hUC-MSCs on Tfh B6.MRL-Fas<sup>lpr</sup> mice. <h3>Methods</h3> percentages spleen C57BL/6 (B6) were examined by flow...
Abstract In strong contrast to the limited repair within mammalian central nervous system, spinal cord of adult zebrafish is capable regeneration following injury. Understanding mechanism underlying neural and functional recovery in cord-injured may lead effective therapies for human injury (SCI). Since neuropeptide Y (NPY) plays a protective role pathogenesis several neurological diseases, present study, effects NPY on neuronal subsequent motor function post-SCI were evaluated. Real-time...