Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol. By an unknown mechanism, they direct coupling radicals toward formation (+)- or (-)-pinoresinol. We show here that dirigent protein AtDIR6 Arabidopsis thaliana is a homodimeric all-beta in superfamily calycins. Based its homology with calycins, structure was modeled using allene oxide cyclase as template. The structural model...

As a consequence of the permanently increasing complexity modeling and simulation (M&S) applications, demand for controlling demonstrating quality model its applications by introducing adequate measures, techniques, tools is obvious. Since efforts toward assurance such as documentation verification validation (V&V) are time consuming costly, reasonable balance between efficiency should be achieved in all practical applications. In context an integrated strategy, several quality-...

Let X be a one-dimensional strong Markov process with continuous sample paths. Using Volterra-Stieltjes integral equation techniques we investigate Hölder continuity and differentiability of first passage time distributions respect to lower upper moving boundaries. Under mild assumptions on the transition function prove existence density one-sided differentiable boundaries derive new for this density. We apply our results Brownian motion its nonrandom Markovian transforms, in particular...

Multi-agent simulations gain more and importance for the simulation of complex systems. In order to meet continuously increasing requirements regarding complexity, level detail, size model on one hand an efficient modeling execution other hand, a reasonable theoretical foundation is essential. Based awareness that at current time these foundations multi-agent are weak in comparison paradigms, necessity general approach defining describing examined. Following this investigation, exemplary...

We present osm2rdf, a tool for converting OpenStreetMap (OSM) data to RDF triples, along with an efficient SPARQL endpoint and convenient user interface formulating queries on that data. Unlike previous tools, osm2rdf retains all provided by OSM, including the complete object geometries. Optionally, can output explicit triples realizing spatial relations contains intersects. provide weekly updates of (for whole planet also per continent country) https://osm2rdf.cs.uni-freiburg.de. The is...

Caching has been recognized as one of the most important techniques to reduce Internet bandwidth in WWW. Different caching algorithms have developed achieve this task. These for specific contexts and show different performance values depending on their application domains. This is caused by fact that each algorithm rates document characteristics more than others. In paper we compare well-known strategies with respect types. For purpose, use trace-driven simulation consider resulting hit well...

For reasons of increasing productivity, efficiency, and decreasing time cost for complex system innovations, modelling simulation (M&S) becomes a standard "tool" huge variety applications.The demand controlling demonstrating the quality model its applications by introducing appropriate measures, techniques, tools is obvious.Consequently, structured even standardized processes development as well verification validation (V&V) has been proposed.All them require, however, due to different...

This paper proposes a modelling methodology combining simulation and analysis for computer performance evaluation prediction. The is based on special workload model that suitable the generation description of dynamic program behaviour. A this given in section 2. applicability concept with respect to design new storage systems, as well improvement or comparison existing will be described by investigation efficiency small cache memories 3.

Enthusiasm for high-tech, simulation-based training should never obscure the fact that trainees must be validly and dependably trained to perform tasks given standard metrics. The educational performance effectiveness of any such method, simulation model scenario therefore rigorously verified validated. Stringent quantitative acceptance criteria applied allow fair detailed skill-training comparisons with traditional methods. challenges verifying validating a proposed generic architecture...

Let X be a one-dimensional strong Markov process with continuous sample paths. Using Volterra-Stieltjes integral equation techniques we investigate Hölder continuity and differentiability of first passage time distributions respect to lower upper moving boundaries. Under mild assumptions on the transition function prove existence density one-sided differentiable boundaries derive new for this density. We apply our results Brownian motion its nonrandom Markovian transforms, in particular...

Regarding permanently increasing complexity and connectivity of technical systems, decreasing innovation cycle times for the design development, systems life time, performance model simulation development application becomes a real challenge. One conceptual approach to increase efficiency effectiveness complex models is component-based design, execution based on reusable components in distributed environment. This presentation will summarize state-of-the-art midterm perspectives modeling...