A5037934051- Parasitic infections in humans and animals
- Parasites and Host Interactions
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- HIV Research and Treatment
- COVID-19 epidemiological studies
- RNA modifications and cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Congenital Anomalies and Fetal Surgery
- Extracellular vesicles in disease
- Parasite Biology and Host Interactions
- Diabetes and associated disorders
- Histone Deacetylase Inhibitors Research
- Cardiovascular Function and Risk Factors
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Mosquito-borne diseases and control
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
Université de Montréal
2021-2023
Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
2023
University of Sussex
2020
Oklahoma State University
2014-2015
University of Pennsylvania
2014-2015
Cancer Research Institute
2014
Neurocysticercosis is common in regions endemic for Taenia solium. Active-stage neurocysticercosis can be treated with antiparasitic medication, but so far no study on efficacy and safety has been conducted Africa.We a prospective cohort treatment of Tanzania between August 2018 January 2022. Patients were initially albendazole (15 mg/kg/d) 10 days followed up 6 months. Additionally July 2021, all participants who then still had cysts offered combination therapy consisting praziquantel (50...
Diabetes is a chronic inflammatory disease that carries high risk of cardiovascular disease. However, the pathophysiological link between these disorders not well known. We hypothesize TLR4 signaling mediates fat diet (HFD)-induced peripheral and cardiac glucose metabolic derangements. Mice with loss-of-function mutation in (C3H/HeJ) age-matched control (C57BL/6) mice were fed either high-fat or normal for 16 weeks. Glucose tolerance plasma insulin measured. Protein expression transporters...
The presence of perilesional edema among patients with parenchymal neurocysticercosis (pNCC) various lesion subtypes has not been correlated results serum enzyme-linked immunotransfer blot (EITB) for cysticercal antibodies.In total, 521 pNCC were classified into solitary cysticercus granuloma (SCG), multiple lesions, at least one which was an enhancing (GMNCC), calcified (SCC) and lesions (CMNCC). proportion EITB positivity each subtype its association determined.There significantly higher...
Abstract Deregulation of cellular epigenetics is essential for malignant transformation. However, the mechanisms that cause epigenetic alterations in cancer cells are incompletely understood. Recent evidence has shown metabolism a direct impact on epigenome, since many chromatin-modifying enzymes rely intracellular metabolites as cofactors or donor substrates. We have previously metabolic enzyme ATP-citrate lyase (ACLY), which generates nuclear-cytoplasmic acetyl-CoA from glucose, required...
Diabetes mellitus is an epidemic disease characterized by alterations in glucose transport, which tightly regulated a family of specialized proteins called the transporters (GLUTs). Although diabetic cardiomyopathy common complication patients, its pathogenesis still not well understood. Toll-like receptor (TLR) 4, plays central role pathogen recognition innate immune system, may also play critical linking inflammation and metabolic disease. We hypothesized that TLR4 activation triggers...