A5043802959- Veterinary Orthopedics and Neurology
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Orthopedic Surgery and Rehabilitation
- Veterinary Equine Medical Research
- Cervical Cancer and HPV Research
- Spine and Intervertebral Disc Pathology
- Hip disorders and treatments
- Bone fractures and treatments
- Metabolism, Diabetes, and Cancer
- Advanced MRI Techniques and Applications
- Metabolism and Genetic Disorders
- Medical Image Segmentation Techniques
- Advanced Neuroimaging Techniques and Applications
- Tendon Structure and Treatment
- Veterinary Oncology Research
- Diet and metabolism studies
- Neural Networks and Applications
- Elbow and Forearm Trauma Treatment
- Food Allergy and Anaphylaxis Research
- Global Cancer Incidence and Screening
- Endometrial and Cervical Cancer Treatments
- Mitochondrial Function and Pathology
- Peroxisome Proliferator-Activated Receptors
- Analytical Chemistry and Chromatography
Massey University
2015-2024
Agios Pharmaceuticals (United States)
2023-2024
University of Edinburgh
2008-2020
University of Zurich
2018
University of Pennsylvania
2013-2018
Translational Therapeutics (United States)
2015-2018
Royal Veterinary College
2018
John Wiley & Sons (United States)
2018
Moss Landing Marine Laboratories
2018
Hudson Institute
2018
Background— The failing human heart is characterized by metabolic abnormalities, but these defects remains incompletely understood. In animal models of failure there a switch from predominance fatty acid utilization to the more oxygen-sparing carbohydrate metabolism. Recent studies have reported decreases in myocardial lipid content, inclusion diabetic and nondiabetic patients obscures distinction adaptations derangements per se. Methods Results— We performed both unbiased targeted surveys...
Abstract The precise characterization of cortical connectivity is important for the understanding brain morphological and functional organization. Such conveyed by specific pathways or tracts in white matter. Diffusion‐weighted magnetic resonance imaging detects diffusivity water molecules three dimensions. Diffusivity anisotropic oriented tissues such as fiber tracts. In present study, we used this method to map (in terms orientation, location, size) “stem” (compact portion) principal...
Macrophage activation/polarization to distinct functional states is critically supported by metabolic shifts. How polarizing signals coordinate and reprogramming, the potential implications for control of macrophage activation, remains poorly understood. Here we show that IL-4 signaling co-opts Akt-mTORC1 pathway regulate Acly, a key enzyme in Ac-CoA synthesis, leading increased histone acetylation M2 gene induction. Only subset genes controlled this way, including those regulating cellular...
A screening programme to detect preinvasive carcinoma of the cervix was started in British Columbia 1949. Since 1970 number women who have been screened at least once has maintained about 85% population risk. More than 500 000 cervical smears are being examined each year central laboratory. There an appreciable increase cases and rates situ seen since 1970, particularly between 20 30 years age. over 26 squamous detected treated. The incidence clinically invasive fallen by 78% during period...
<b>Objective</b> To identify major concerns of national and local importance in the provision, commissioning, research, use generalist end life care. <b>Design</b> A consultation prioritising exercise using a modified form nominal group technique. <b>Participants</b> Healthcare practitioners, commissioners, academics, representatives user voluntary groups. <b>Setting</b> Primary secondary care, specialist palliative academic sectors England Scotland. <b>Results</b> 74% those invited...
The antitumor agent lonidamine (LND; 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid) is known to interfere with energy-yielding processes in cancer cells. However, the effect of LND on central energy metabolism has never been fully characterized. In this study, we report that a significant amount succinate accumulated LND-treated inhibits formation fumarate and malate suppresses succinate-induced respiration isolated mitochondria. Utilizing biochemical assays, determined...
Abstract Etomoxir (ETO) is a widely used small-molecule inhibitor of fatty acid oxidation (FAO) through its irreversible inhibitory effects on the carnitine palmitoyl-transferase 1a (CPT1a). We this compound to evaluate role in rapidly proliferating T cells following costimulation CD28 receptor. show that ETO has moderate effect cell proliferation with no observable memory differentiation, but marked oxidative metabolism. metabolism primarily dependent upon glutamine rather than FAO. Using...
<b>Objectives</b> To examine the care experiences of South Asian Sikh and Muslim patients in Scotland with life limiting illness their families to understand reasons for any difficulties access services how these might be overcome. <b>Design</b> Prospective, longitudinal, qualitative design using in-depth interviews. <b>Setting</b> Central Scotland. <b>Participants</b> 25 purposively selected patients, 18 family carers, 20 key health professionals. <b>Results</b> 92 interviews took place....
Summary The follow‐up data of 4389 treated cases preclinical squamous carcinoma the cervix is presented. After 5 years 1.86 per cent patients with in situ had developed further disease and after ten 8.2 percent disease. These rates indicate need for prolonged careful follow‐up. Hysterectomy does not mean end as there appears to be a significant risk developing recurrent or new foci vaginal vault hysterectomy. Carcinoma microinvasive behave much same fashion , so that similar treatment would...
Replication stress induced by nucleotide deficiency plays an important role in cancer initiation. primary cells typically activates the cellular senescence tumor-suppression mechanism. Senescence bypass correlates with development of cancer, a disease characterized metabolic reprogramming. However, reprogramming response to replication has been little explored. Here, we report that ataxia telangiectasia mutated (ATM) central regulating shifting metabolism. ATM inactivation bypasses triggered...
Interval cancers in an annual mammography screening program are defined as detected within 12 months after a mammographic which findings considered normal. Our objective was to analyze interval for histologic type, tumor size, staging, and grade. A classification is presented. Detection of integral part quality control required the establishment sensitivity rates mammography, necessary implementing recommendations breast cancer screening.A total 47,583 examinations 38,219 women were...
Cite this as : M. Gallagher, A. Worth, S. Cunningham‐Burley and Sheikh, Clinical & Experimental Allergy , 2011 (41) 869–877. Summary Background Adolescents with severe allergies are at particular risk of fatal anaphylactic reactions. Epinephrine (adrenaline) is known to be under‐utilized by teenagers. Objective We sought gain knowledge adolescents' attitudes towards experience epinephrine auto‐injectors in order inform improvements patient education. Methods A qualitative study...
Abstract Instruments have been developed and validated for the measurement of health‐related quality life in patients with food allergy. This guideline has prepared by European Academy Allergy Clinical Immunology's ( EAACI ) Guidelines Food Anaphylaxis Group . It draws on a systematic review literature instruments allergy Appraisal Research & Evaluation AGREE II development process. Guidance is provided use such research, current limitations their clinical practice are described. Gaps...
Tamoxifen is the most widely used adjuvant chemotherapeutic for treatment of estrogen receptor (ER)-positive breast cancer, yet a large body clinical and preclinical data indicates that tamoxifen can modulate multiple cellular processes independently ER status. Here, we describe ER-independent effects on tumor metabolism. Using combined pharmacologic genetic knockout approaches, demonstrate inhibits oxygen consumption via inhibition mitochondrial complex I, resulting in an increase AMP/ATP...
The periodic acid-thionin Schiff/potassium hydroxide/periodic acid-Schiff (PAT/KOH/PAS) procedure has been used to investigate the histochemical staining characteristics of mucins found in adenocarcinoma and villous lesions large intestine. 46 blocks examined represented 58 from 37 patients, all whom had resections for carcinoma colon. tin sharp contrast normal colon, none adenocarcinomas stained red with PAT/KOH/PAS. With two exceptions poorly moderately differentiated blue, whereas well...
Three children, aged 7 months, 1 year, and 13 years, were found to have anemia thrombocytopenia. Bone marrow examination showed an increase in myeloid elements all 3 a slight blast cells (14%) the second child. Examination of bone chromosomes missing group C chromosome while peripheral lymphocytes stimulated with phytohemagglutinin gave predominantly normal 46 pattern. Serial hematologic chromosomal analyses blood obtained throughout course disease process. All children eventually died from...
Rationale Mass spectrometric (MS) analysis of low molecular weight polar metabolites can be challenging because poor chromatographic resolution isomers and insufficient ionization efficiency. These include intermediates in key metabolic pathways, such as glycolysis, the pentose phosphate pathway, Krebs cycle. Therefore, sensitive, specific, comprehensive quantitative these biological fluids or cell culture models provide insight into multiple disease states where perturbed metabolism plays a...