A5041087327- Synthesis and biological activity
- Computational Drug Discovery Methods
- Synthesis and Characterization of Heterocyclic Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cytokine Signaling Pathways and Interactions
- Solid-state spectroscopy and crystallography
- Phytochemistry and Biological Activities
- Carbohydrate Chemistry and Synthesis
- Spectroscopy and Chemometric Analyses
- Synthesis and Reactions of Organic Compounds
- Bioactive Compounds and Antitumor Agents
- Synthesis and Biological Evaluation
- Synthesis of Indole Derivatives
- DNA and Nucleic Acid Chemistry
- Synthesis of Organic Compounds
- Phytochemicals and Antioxidant Activities
- Cholinesterase and Neurodegenerative Diseases
University of Chittagong
2015-2021
Different esters were found potential against microorganisms, and could be a better choice to solve the multidrug resistant (MDR) pathogenic global issue due their improved biological pharmacokinetic properties. In this view, several 4-t-butylbenzoyl uridine 4–15 with different aliphatic aromatic groups synthesized for antimicrobial, physicochemical studies. vitro antimicrobial tests nine bacteria three fungi along prediction of activity spectra substances (PASS) indicated promising...
In our present investigation a new series of nucleoside derivatives (2-13) were synthesized from uridine (1) via only two step reactions by direct acylation method.Firstly, was treated with 4-t-butylbenzoyl chloride in pyridine at -5ºC and afforded the 5´-O-(4-tbutylbenzoyl)uridine derivative (2) an excellent yield.In order to obtain newer products, 5´-O-uridine further transformed 2´,3´-di-O-acyl containing wide variety functionalities single molecular framework.The yields compounds more...
A new N-acetylsulfanilylation series of uridine have been synthesized in good yield using direct acylation method and afforded the 5'-O-N-acetylsulfanilyluridine. In order to obtain newer products, 5'-O-N-acetylsulfanilyluridine derivative was further transformed a 2',3'-di-O-acyl derivatives containing wide variety functionalities single molecular framework. The chemical structures newly compounds were confirmed on basis their FTIR, 1H-NMR spectroscopy, physicochemical properties elemental...
Dimolar pentanoylation of methyl α-D-glucopyranoside using direct method furnished the 2,6-di-O-pentanoate indicating regioselectivity at C-6 and C-2 positions. To develop glucopyranoside based potential antimicrobial agents, was further converted into eight newer 3,4-di-O-acyl esters reasonably in good yields. Both prediction activity spectra for substances (PASS) vitro test established them as better antifungals than antibacterials. PASS predication also indicated that these sugar (SEs)...
601-тренажер-имитаторын пайдалана отырып, студенттерді өндіріске баулу ақпараттық технологиялар ғасырының талабына сай келеді. Қазіргі қоғамда жаңа технологияларды жан-жақты меңгерген, бәсекеге қабілетті тұлға қалыптастыру қажет. Мұғалімнің кәсіби құзыреттілігі мен шеберлігі, оқытудың әдістерін меңгеруі маңызды рөл атқарады. Арнайы пәндерді оқытуда қолдану студенттердің пәнге деген қызығушылығын арттырып, шығармашылығын дамытуға, дербес жұмыстарын ұйымдастыруға жағдай жасайды. Мақалада...
Monosaccharide esters (MEs) are getting more attention from bioorganic chemists due to their biodegradable and drug-likeness properties. As a consequence, carbohydrate derivatives (sugar-based esters, SEs) an essential part of medicinal chemistry. In this context, density functional theory (DFT) with B3LYP/ 3-21G has been employed optimize the methyl 4,6-O-benzylidene-α-D-glucopyranoside (3) α-D-glucopyranoside (2) its protected acyl 4-6. The prediction activity spectra for substances (PASS)...
Over the past several decades significant biological activities including brains protective and antimicrobial have made sugar esters (SEs) as a topic of great interest. In this context, unimolar 3-chlorobenzoylation methyl α-L-rhamnopyranoside (4) using dibutyltin oxide method regioselectively furnished only 3-O-substitution product 5 in excellent yield. The reaction proceeded via formation cyclic 2,3-O-dibutylstannylene intermediate where equatorial hydroxyl group is activated by tin atom...