A5049581349- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Extracellular vesicles in disease
- Retinoids in leukemia and cellular processes
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Acute Lymphoblastic Leukemia research
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Venomous Animal Envenomation and Studies
- Genetic and Kidney Cyst Diseases
- Hematopoietic Stem Cell Transplantation
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Biopolymer Synthesis and Applications
- Therapeutic Uses of Natural Elements
- Endoplasmic Reticulum Stress and Disease
- Ferroptosis and cancer prognosis
- Esophageal and GI Pathology
- Advanced biosensing and bioanalysis techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Research Studies
- Inflammasome and immune disorders
Peking University People's Hospital
2015-2025
Peking University
2015-2025
Huazhong University of Science and Technology
2024
Tongji Hospital
2024
Honghu Hospital of Traditional Chinese Medicine
2022-2024
Hainan Medical University
2023
Zhejiang Hospital
2023
Nanjing Medical University
2022
Jiangsu Cancer Hospital
2022
Yangtze University
2022
Abstract Extracellular vesicles (EVs) have gained increasing recognition as significant regulators of intercellular communication in various physiological and pathological processes. These play a pivotal role cancer progression by facilitating the transfer diverse cargoes, including lipids, proteins, nucleic acids. Regulated cell death (RCD), orderly autonomous cells, is controlled variety biomacromolecules and, turn, influences biological processes progression. Recent studies demonstrated...
Abstract Background Even after achieving complete remission (CR), many acute myeloid leukaemia (AML) patients suffer from poor haematopoietic recovery chemotherapy. Previous studies have shown that the damage of bone marrow endothelial progenitor cell (BM EPC) hinders chemotherapy in mice. Therefore, elucidation mechanism and repair strategy chemotherapy‐induced BM EPC is urgent needed. Methods The prospective case–control study enrolled 40 AML CR (CR patients), who received idarubicin...
Colorectal cancer (CRC) is one of the leading causes cancer-related deaths globally. Metastasis associated with a poor prognosis, yet underlying molecular mechanism(s) remained largely unknown. In this study, total 85 CRC patients were included and primary tumor lesions evaluated by next-generation sequencing using targeted panel for genetic aberrations. Patients sub-divided according to their metastasis pattern into non-organ metastases (Non-OM) organ (OM) groups. By comparing differences...
Somatostatin analogues (SSTA) are first-line pharmacological treatment choice for acromegaly, which received satisfying tumor shrinkage and normalization of growth hormone.However, there still patients unresponsive to SSTA, the underline mechanism remains unknown.Besides, is no evidence regarding role endoplasmic reticulum stress (ERS) its transmission in SSTA resistance, also require investigation.Primary hormone adenoma cells cell lines were treated with SSTA; autophagy double-labeled LC3...
In order to explore the risk factors of relapse and potential optimized therapeutic regimen low-risk acute promyelocytic leukaemia (APL), here we retrospectively analysed 282 patients who were diagnosed between February 2014 September 2021. The median follow-up was 59 (9-102) months. 5-year overall survival cumulative incidence 97.9% 5.9%, respectively. terms different cytoreductive therapies, 86 administered with hydroxycarbamide (30.5%), 113 anthracyclines or cytarabine (40.1%), 31...
Anti-PD-1 monoclonal antibody is approved as an option for third-line treatment of advanced gastric and gastroesophageal junction (G/GEJ) cancer in several countries, but no anti-PD-1 yet first-line G/GEJ cancer. We report a phase Ib trial HX008, highly selective, humanized anti-programmed death-1 antibody, plus oxaliplatin capecitabine Patients with previously untreated, locally or metastatic were enrolled. All patients received HX008 3 mg/kg intravenously every weeks, 130 mg/m2 on day 1...
The combination of platinum and gemcitabine is one the standard regimens in treatment advanced lung squamous carcinoma (LSC). Resistance to main barrier successful LSC. In this study, we showed that suppression Fanconi anemia (FA) pathway increased sensitivity two LSC cell lines SK-MES-1 KLN205 gemcitabine. Moreover, found CHK1 FA are functionally compensatory repair DNA damage lines. Inactivation pathways led damage, triggering activation other pathway. Furthermore, demonstrated FANCD2...
Abstract To investigate factors related to poor prognosis of patients with stage IV esophageal cancer and provide some bases on which proper therapeutic schemes could be formulated for performance status (PS) score between 0 2. Clinical data 60 were retrospectively analyzed, the relationships clinical characteristics methods patients’ explored. Univariate analysis possibly affecting was performed using Log-rank test, independent risk estimated in multivariate Cox regression through embracing...
Abstract Background: The activin-like kinase receptor 1 (ALK-1, encoded by ACVRL1) is a member of the transforming growth factor β (TGF-β) superfamily. Combination treatment using anti-PD-1/PD-L1 agents with anti-angiogenetic reagents might bring additional benefits, such as establishing favorable TME leading to better responses towards immunotherapy. In phase II clinical trial (NCT03893695) combination therapy ALK-1 (GT90001) and Nivolumab for second line in patients metastatic...
It is common knowledge that immunoglobulin (Ig) produced by B lymphocytes and mainly functions as an antibody. However, it has been shown recently myeloblasts from acute myeloid leukemia (AML) could also express Ig AML-Ig played a role in leukemogenesis AML progression. The difference between cells not explored. Studying the characteristics of repertoire will be helpful to understand function significance AML-Ig. We performed 5' RACE-related PCR coupled with PacBio sequencing analyze Chinese...
e21213 Background: There is no effective treatment strategy for patients with advanced non-small cell lung cancer (NSCLC) who experienced progression one or two lines of chemotherapy. Apatinib, a new tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2 (VEGFR-2), has been shown promising antitumor activity and manageable toxicities in NSCLC. The purpose this study was to evaluate the effectiveness safety apatinib combined docetaxel Methods: This multicenter,...