A5109660874- Chronic Myeloid Leukemia Treatments
- Eosinophilic Disorders and Syndromes
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Suicide and Self-Harm Studies
- Cancer survivorship and care
- Acute Lymphoblastic Leukemia research
- Posttraumatic Stress Disorder Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Uterine Myomas and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- MicroRNA in disease regulation
- Diagnosis and treatment of tuberculosis
- Guidance and Control Systems
- Intergenerational Family Dynamics and Caregiving
- Marine Sponges and Natural Products
- Injury Epidemiology and Prevention
- Synthesis of Tetrazole Derivatives
- Lung Cancer Treatments and Mutations
- Disaster Management and Resilience
- Traumatic Brain Injury Research
- Resilience and Mental Health
- Biochemical and Structural Characterization
- Complementary and Alternative Medicine Studies
- Microbial Natural Products and Biosynthesis
University of Hong Kong
2025
Peking University People's Hospital
2008-2024
Peking University
2008-2024
State Key Laboratory of Natural and Biomimetic Drugs
2024
National Clinical Research
2024
Weatherford College
2024
Shandong First Medical University
1999-2024
WuXi AppTec (China)
2024
Shanghai Ninth People's Hospital
2024
Kwong Wah Hospital
2024
Background Although the independent effects of childhood adversities and recent negative events on suicidality have been well-documented, combinative role risk for is still underexplored, especially in context Chinese culture consideration specific types events. Method 5989 students, randomly sampled from six universities central China, completed online survey this study. Suicidal behavior, life adversity during stressful school were assessed with designed questionnaires. Results Students...
Abstract Diabetic limb ischemia (DLI) is a frequent complication of diabetes and the leading cause non‐traumatic amputation. Traditional treatments like stent placement bypass surgery may not suit all patients. Exosome transplantation has emerged as promising therapy. Netrin1, protective cardiovascular factor, an unclear role in DLI. This study investigates Netrin1 DLI patients evaluates therapeutic potential exosomes derived from Netrin1‐overexpressing adipose‐derived stem cells (N‐ADSCs)....
Whether there is really a distinct accelerated phase (AP) at diagnosis in chronic myeloid leukaemia (CML) the context of tyrosine kinase-inhibitor (TKI)-therapy controversial. We studied 2122 consecutive subjects (CP, n = 1837) or AP (n 285) classified according to 2020 European LeukemiaNet (ELN) classification. with increased basophils only had similar transformation-free survival (TFS) and compared CP as ELTS intermediate-risk. Those blasts worse TFS but high-risk. decreased platelets...
Little is known about the information on sexually transmitted disease (STD)/AIDS in population working congregating trading markets China. A cross-sectional study was conducted among three big Hefei City. Seven hundred fifty-two market vendors completed a questionnaire, 333 of two provided specimen for STD/HIV testing. The majority China are active youths and adults, have little education. had poor knowledge STD/AIDS. rates correct answers to questions STD/AIDS varied between 21.1%–81.9%....
Mental health problems in the general population have been reported during SARS-CoV-2 pandemic; however, there were rare data persons with chronic myeloid leukemia (CML). Therefore, we performed a cross-sectional study on mental evaluated using 9-item Patient Health Questionnaire (PHQ-9; depression), 7-item Generalized Anxiety Disorder (GAD-7; anxiety), and 22-item Impact of Event Scale—Revised (IES-R; distress), including subscales avoidance, intrusion, hyper-arousal CML, non-cancer...
Pulmonary hypertension (PH) is a rare but life-threatening adverse event (AE) of dasatinib, the associated variables are not clear. This study aimed to explore with PH by echocardiography in patients chronic myeloid leukemia phase (CML-CP) receiving dasatinib therapy.Echocardiography was performed estimate probability and pulmonary artery systolic pressure (PASP). Binary logistic analysis Fine-Gray hazard model were used identify using cross-sectional longitudinal data.Among 243 dataset,...
Abstract Chimeric antigen receptor-modified T cells (CAR-T) have been widely applied in the treatment of hematological malignancies and are currently under investigation for their potential effectiveness against solid tumors. Nevertheless, CAR-T treating tumors remains unsatisfactory due to a range factors, including cell infiltration heterogeneity. The efficacy therapy is substantially influenced by tumor microenvironment. This particularly evident when PD-L1 activated through CAR-T,...
<title>Abstract</title> Whether there is really a distinct accelerated phase (AP) at diagnosis in chronic myeloid leukemia (CML) the context of tyrosine kinase-inhibitor (TKI)-therapy and whether co-variates identified as characterizing AP are simply adverse for outcomes, we studied 2,122 consecutive subjects (CP, n = 1,837) or (n 285) according to European LeukemiaNet (ELN) classification. with increased basophils only had similar transformation-free survival (TFS) compared CP ELTS...
Abstract Objective Mass Casualty Incidents (MCIs) involving high-speed passenger ferries (HSPFs) may result in the dual-wave phenomenon, which emergency department (ED) is overwhelmed by an initial wave of minor injuries, followed a second more seriously injured victims. This study aimed to characterize time pattern ED presentation victims such accidents Hong Kong. Methods All HSPF MCIs from 2005 2015 were reviewed retrospectively, with interval accident registration determined for each...
A new cyclopentapeptide, cotteslosin D (1), was isolated from the cultures of a sponge-derived fungus Aspergillus versicolour 2-18. The structure 1 eluvidated as cyclo-(N-Me-L-Tyr-L-Val-L-Pro-L-Tyr-L-Phe) on basis extensive spectroscopic analysis and chemical methods. Compound displayed weak antibacterial activities against Escherichia coli Staphylococcus aureus.
<title>Abstract</title> Blood basophils ≥ 20 percent is reportedly associated with a poor prognosis and used to define accelerated phase of chronic myeloid leukaemia (CML) in some classifications. However, quantification blood by percentage inaccurate. Using Patient Similarity Network (PSM) approach we identified basophil concentration rather than as the more accurate predictive co-variate. To test this observation interrogated data for possible correlation between quantified training cohort...
Objective To explore the surgical treatment of Crohn's disease(CD).Methods Clinical data 11 patients with disease undergoing surgery were retrospectively analyzed.Results 9 cases diagnosed before operation,with symptoms including abdomen pain,diarrhea or constipation,weight loss,and segmental lesions.Abdominal mass was most common cause,accounting for 54.5%(6/11)in surgery,and intestinal obstruction secondary.accounting 36.4%(4/11),and perianal abscess,9.1%(1/11).Partial enterectomy and...
Introduction:The precise etiology and physiopathology of ademyosis is still unknown.The aim this research to investigate if stem cells are found in adenomyosis characterize the role adenomyotic lesion-derived side population (SP) pathogenesis adenomyosis.Methods: We recruited 31 women (range 37-48 years) treated by hysterectomy for adenomyosis.Adenomyotic samples were collected The SP tissues identified flow cytometry.ATP-binding cassette transporter 2 + (ABCG2 ) isolated from human magnetic...