A5100768306- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- S100 Proteins and Annexins
- Identification and Quantification in Food
- Diabetes Treatment and Management
- Blood Coagulation and Thrombosis Mechanisms
- Liver Disease Diagnosis and Treatment
- Genomics and Phylogenetic Studies
- Metabolism and Genetic Disorders
- Stress Responses and Cortisol
- Analytical Chemistry and Chromatography
- RNA Interference and Gene Delivery
- Diabetes and associated disorders
- Menopause: Health Impacts and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Metabolomics and Mass Spectrometry Studies
- Vasculitis and related conditions
- Renal cell carcinoma treatment
- Biomarkers in Disease Mechanisms
- Genetic diversity and population structure
- Aldose Reductase and Taurine
- Traditional Chinese Medicine Analysis
- Cancer Research and Treatments
- Urinary Bladder and Prostate Research
- Diet and metabolism studies
Peking University
2018-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Peking University First Hospital
2018-2024
Ministry of Education of the People's Republic of China
2023
First Affiliated Hospital of Wenzhou Medical University
2021
Wenzhou Medical University
2021
Central South University of Forestry and Technology
2018
Central South University
2018
East China University of Science and Technology
2014
University of Hawaiʻi at Mānoa
2012
Inflammation and abnormal metabolism play important roles in the pathogenesis of diabetic nephropathy (DN). Annexin A1 (ANXA1) contributes to inflammation resolution improves metabolism. In this study, we assess effects ANXA1 mice proximal tubular epithelial cells (PTECs) treated with high glucose plus palmitate acid (HGPA) explore association lipid accumulation patients DN. It is found that deletion aggravates renal injuries, including albuminuria, mesangial matrix expansion,...
Although the current literature has recorded many reports of identifying components from herbal preparations, all them were largely limited to target components. This paper provides a novel and generally applicable approach nontarget based on use liquid chromatography ion trap time-of-flight mass spectrometry (LC/MS-IT-TOF). A simple program was originally developed for searching common diagnostic ions experimentally generated ions. The sharing exact same (mass error < 5 mDa) classified into...
In diabetic kidney disease (DKD), it is important to find biomarkers for predicting initiation and progression of the disease. Besides glomerular damage, tubular injury inflammation are also involved in development DKD. The current study investigated associations urinary epidermal growth factor (uEGF), monocyte chemotactic protein-1 (MCP-1) uEGF:MCP-1 ratio with involvement patients at early advanced stages DKD.The concentration uEGF uMCP-1 was measured two Chinese population-based studies....
Background The tilapia family of the Cichlidae includes many fish species, which live in freshwater and saltwater environments. Several such as O. niloticus, aureus, mossambicus, are excellent for aquaculture because these easily reproduced readily adapt to diverse Historically, including S. melanotheron, were introduced Hawaii decades ago, state uses import permit policy prevent niloticus from coming into islands. However, hybrids produced may already be present marine environments purpose...
Increasing studies demonstrated the importance of activation neutrophils in pathogenesis antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV). Previous showed that annexin A1 (ANXA1) inhibited recruitment, transendothelial migration and respiratory burst induced apoptosis neutrophils. The current study aimed to investigate plasma renal levels ANXA1 as well their association with disease severity AAV patients.Thirty-one patients active stage 35 remission were recruited....
An aldo-keto reductase AKR5C3 from Gluconobacter oxydans (designated as Gox0644) is a useful enzyme with various substrates, including aldehydes, diacetyl, keto esters, and α-ketocarbonyl compounds. The crystal structures of in apoform complex NADPH the D53A mutant (AKR5C3(-D53A) ) are presented herein. Structure comparison site-directed mutagenesis combined biochemical kinetics analysis reveal that conserved Asp53 catalytic tetrad has crucial role securing active pocket conformation....
Diabetic kidney disease (DKD), the major cause of chronic disease, is associated with progressive renal fibrosis. The expression CD90 correlated fibrogenesis. However, association between urinary soluble and severity, whether it predicts outcomes in patients DKD are still unclear.Urinary sCD90 was measured 285 a longitudinal cohort. composite endpoint defined as end-stage (ESRD) or 40% reduction estimated glomerular filtration rate (eGFR). associations sCD90/Cr clinical parameters, well were...
Background: Chronic kidney disease (CKD) is significantly influenced by mitochondrial dysfunction (MD). Previous research suggests that methylmalonic acid (MMA) involved in MD. Consequently, we aimed to investigate associations between blood MMA level and the prevalence of CKD as well mortality patients with CKD. Methods: The study included 23,587 individuals from National Health Nutrition Examination Survey (NHANES). NHANES datasets 1999–2004 2011–2014 were utilized separate primary...