A5076530500- SARS-CoV-2 and COVID-19 Research
- Olfactory and Sensory Function Studies
- SARS-CoV-2 detection and testing
- Nasal Surgery and Airway Studies
- Sinusitis and nasal conditions
- Nerve injury and regeneration
- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
- Forensic Toxicology and Drug Analysis
- Bacterial Infections and Vaccines
- Alcoholism and Thiamine Deficiency
- Allergic Rhinitis and Sensitization
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Chemical Sensor Technologies
- Animal Virus Infections Studies
- Nitric Oxide and Endothelin Effects
- GABA and Rice Research
- Neurological Disease Mechanisms and Treatments
- Biosensors and Analytical Detection
- Cannabis and Cannabinoid Research
- Diet, Metabolism, and Disease
- Vaccine Coverage and Hesitancy
- Cardiovascular Health and Disease Prevention
- Alzheimer's disease research and treatments
University of Rome Tor Vergata
2019-2024
SARS-CoV-2 antibody assays are crucial in managing the COVID-19 pandemic. Approved mRNA vaccines well known to induce a serum responses against spike protein and its RBD. Mucosal immunity plays major role fight directly at site of virus entry; however, vaccine abilities elicit mucosal immune have not been reported. We detected anti-SARS-CoV-2 IgA-S1 IgG-RBD three study populations (healthy controls, vaccinated subjects, subjects recovered from infection) on serum, saliva, nasal secretions...
Olfactory impairment, particularly hyposmia and anosmia, has emerged as a distinctive early symptom of SARS-CoV-2. Drawing on the historical association autoimmune diseases with olfactory function, this study delves into connections between COVID-19, autoimmunity, persistent dysfunctions, focusing individuals experiencing long-lasting smell disorders (3–18 months post-SARS-CoV-2 infection). The comprised 36 Long Covid patients alongside two control groups. functionality was assessed using...
Many transversal mechanisms act synergistically at different time-points in the cascade of Alzheimer's disease (AD), since amyloid-β (Aβ) deposition, tau pathology, and neuroinflammation influence each other.We explored contributions microglia astrocytes patients with symptomatic sporadic AD stratified according to AT(N) system APOE genotype.We compared cerebrospinal fluid (CSF) levels sTREM-2 markers astrocytic activation (GFAP; β-S100) from 71 (23 A+T-,48 A+T+; 38 APOEɛ3, 33 APOEɛ4) 30...
Remyelination in the adult brain relies on reactivation of Neuronal Precursor Cell (NPC) niche and differentiation into Oligodendrocyte Cells (OPCs) as well OPC maturation myelinating oligodendrocytes (OLs). These two distinct phases OL development are defined by transcriptional morphological changes. How this program is controlled remains unclear. We used drugs that stimulate myelin basic protein (MBP) expression (Clobetasol Gefitinib) alone or combined with epidermal growth factor receptor...
Both the endothelial (eNOS) and neuronal (nNOS) isoforms of constitutive Nitric Oxide Synthase have been implicated in vascular dysfunctions Alzheimer's disease (AD). We aimed to explore relationship between amyloid pathology NO dynamics by comparing cerebrospinal fluid (CSF) levels nNOS eNOS 8 healthy controls (HC) 27 patients with a clinical diagnosis isolated CSF changes, stratified according APOE ε genotype (APOE ε3 = 13, ε4 14). Moreover, we explored associations NOS isoforms, AD...
This longitudinal prospective study aims to investigate the potential of circulating calprotectin (cCLP) as a biomarker in persistent olfactory dysfunctions following COVID-19 infection.
Cannabis remains the most illicitly produced and consumed substance worldwide, average trans-Δ9-tetrahydrocannabinol (THC) content in cannabis products (marijuana, hashish) has increased over time. This paper presents data about THC concentration resin samples seized by law enforcement from 2015 to 2022 southern area of Rome (Italy). From 2022, more than 1000 hashish were analyzed; was 18.0% dramatically 13.7% (2015) 27.1% (2022). The potency some characterized unusual shape color higher 24%...
SARS-CoV-2 severe acute respiratory syndrome has rapidly spread worldwide since 2019. All scientific and technological forces have concentrated towards the formulation of vaccines to contain disease. In less than one year (December 2020) a first messenger RNA vaccine (Comirnaty, BioNTech/Pfizer) was authorized. However, research community wondered about possible side effects on immune system, given administration in phase 4.This study aims evaluate mRNA impact development positive...
Alcohol abuse is still one of the leading causes death worldwide. Early diagnosis alcohol enables preventive intervention on effects and risks associated with its consumption. Carbohydrate-deficient transferrin (CDT) most reliable biomarkers chronic misuse. We retrospectively studied a population 12,624 subjects who had their driving license suspended for under influence or drugs from 2016 to 2022. The analytical determination CDT was performed following certified high-performance liquid...
<title>Abstract</title> Objective and Design: This longitudinal prospective study aims to investigate the potential of circulating calprotectin (cCLP) as a biomarker in persistent olfactory dysfunctions following COVID-19 infection. Materials Methods Thirty-six patients with hyposmia or anosmia post were enrolled (HT0) re-evaluated after three months training (HT1). Two control groups included 18 subjects without defects (CG1) healthy individuals (CG2). Nasal blood samples collected assess...