A5089594351- Clusterin in disease pathology
- Mitochondrial Function and Pathology
- Nuclear Structure and Function
- Aquaculture Nutrition and Growth
- Algal biology and biofuel production
- Endoplasmic Reticulum Stress and Disease
- Lipid metabolism and disorders
- ATP Synthase and ATPases Research
- Protein purification and stability
- Isotope Analysis in Ecology
- thermodynamics and calorimetric analyses
- Heat shock proteins research
- Biomarkers in Disease Mechanisms
- Marine and coastal ecosystems
- S100 Proteins and Annexins
Johannes Gutenberg University Mainz
2013-2023
Clusterin (CLU), also known as Apolipoprotein J (ApoJ) is a highly glycosylated extracellular chaperone. In humans it expressed from broad spectrum of tissues and related to plethora physiological pathophysiological processes, such Alzheimer's disease, atherosclerosis cancer. its dominant form secretory protein (secreted CLU, sCLU). During maturation, the sCLU-precursor N-glycosylated cleaved into an α- β-chain, which are connected by five symmetrical disulfide bonds. Recently, has been...
Clusterin, also known as apolipoprotein J, is expressed from a variety of tissues and implicated in pathological disorders such neurodegenerative diseases, ischemia cancer. In contrast to secretory clusterin (sCLU), which acts an extracellular chaperone, the synthesis, subcellular localization function(s) intracellular CLU isoforms currently matter intense discussion. By investigating human mRNAs we here unravel mechanisms leading synthesis distinct protein analyze their impact on apoptosis...
The use of nanocarriers as drug delivery vehicles brings them into contact with blood plasma proteins. Polymeric require some sort surfactant to ensure colloidal stability. Formation the protein corona is therefore determined not only by intrinsic properties nanocarrier itself but also accompanying surfactant. Although it well-known that surfactants have an impact on structure, few studies were conducted specific effect composition nanocarriers. Therefore, we analyzed "stealth" nanoparticles...
Clusterin, also known as apolipoprotein J, is expressed from a variety of tissues and implicated in pathological disorders such neurodegenerative diseases, ischemia cancer.In contrast to secretory clusterin (sCLU), which acts an extracellular chaperone, the synthesis, subcellular localization function(s) intracellular CLU isoforms currently matter intense discussion.By investigating human mRNAs we here unravel mechanisms leading synthesis distinct protein analyze their impact on apoptosis...
Abstract Blue‐green light is known to maximize the degree of fatty acid (FA) unsaturation in microalgae. However, knowledge on particular waveband responsible for this stimulation FA desaturation and its impact pigment composition microalgae remains limited. In study, Acutodesmus obliquus was cultivated 96 h at 15°C with different spectra (380–700 nm, 470–700 520–700 600–700 dark controls). Growth monitored daily, qualitative characterization microalgal achieved via gas chromatography...
Abstract The spectral composition of light is an important factor for the metabolism photosynthetic organisms. Several blue light‐regulated metabolic processes have already been identified in industrially relevant microalga Monoraphidium braunii . However, little known about impact on this species' growth, fatty acid (FA), and pigment composition. In study, M. was cultivated under different spectra (white light: 400–700 nm, 400–550 green 450–600 red 580–700 nm) at 25°C 96 h. growth monitored...