A5100659623- Cleft Lip and Palate Research
- Cancer-related molecular mechanisms research
- Tissue Engineering and Regenerative Medicine
- Cell death mechanisms and regulation
- Craniofacial Disorders and Treatments
- Mesenchymal stem cell research
- Dermatologic Treatments and Research
- Periodontal Regeneration and Treatments
- RNA modifications and cancer
- Wound Healing and Treatments
- Oral and gingival health research
- Connective Tissue Growth Factor Research
- RNA Research and Splicing
- Plant-based Medicinal Research
- Circular RNAs in diseases
- Bioactive Natural Diterpenoids Research
Capital Medical University
2012-2024
Beijing Chao-Yang Hospital
2017-2021
Il-Yang Pharmaceutical (South Korea)
2006
This study aimed to investigate the effect and underlying mechanism of lncRNA CASC2 in malignant melanoma (MM). Expression MM tissues cells was detected. A375 were transfected with pc-CASC2, si-CASC2, miR-18a-5p inhibitor, or corresponding controls, then cell proliferation, migration, invasion detected using MTT assay, colony formation Transwell analysis, respectively. The relationship RUNX1 by luciferase reporter assay. levels significantly reduced compared normal skin cells, while level...
Transforming growth factor β (TGF-β) is a presenting important functions during tissue remodeling and hypertrophic scar (HS) formation. However, the underlying molecular mechanisms are largely unknown. In this study, we identified thrombospondin-4 (TSP-4) as TGF-β1 target that essentially mediates TGF-β1-induced formation both in vitro vivo. The expression of TSP-4 was compared on mRNA protein levels between fibroblasts (HSFs) normal skin fibroblast (NFs) response to treatment. Two signaling...
Objective: This study aimed to identify novel proteins involved in retinoic acid (RA)-induced embryonic cleft palate development. Method: The tissues of the control and RA-treated E14.5 were dissected subjected iTRAQ-based proteomic analysis. Results: Differential expression analysis identified 196 significantly upregulated 149 downregulated considerably RA-induced tissues. Comprehensive Gene Ontology Kyoto Encyclopedia Genes Genomes enrichment revealed significant involvement cytoplasmic...
Abstract Background All-trans retinoic acid (atRA) results in cleft palate, but the cellular and molecular mechanisms underlying teratogenic effects on palatal development have not been fully elucidated. Autophagy interruption has reported to seriously affect embryonic-cell differentiation development. This study aimed verify whether atRA-induced palate occurs because atRA blocks autophagy stemness of embryonic mesenchyme (MEPM) cells, which are maintained via phosphatase tensin homolog...