A5019909259- HIV/AIDS drug development and treatment
- Biochemical and Molecular Research
- Advanced Mathematical Modeling in Engineering
- DNA and Nucleic Acid Chemistry
- Elasticity and Wave Propagation
- Differential Equations and Boundary Problems
- Organophosphorus compounds synthesis
- Synthesis and Characterization of Heterocyclic Compounds
- Advanced Numerical Analysis Techniques
- Algebraic and Geometric Analysis
- Advanced Numerical Methods in Computational Mathematics
- Pneumocystis jirovecii pneumonia detection and treatment
- Numerical methods in engineering
- Differential Equations and Numerical Methods
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Composite Material Mechanics
- Advanced Theoretical and Applied Studies in Material Sciences and Geometry
- Geotechnical and Geomechanical Engineering
- Metal complexes synthesis and properties
- Analytic and geometric function theory
- Engineering and Agricultural Innovations
- Contact Mechanics and Variational Inequalities
- Structural mechanics and materials
- Biochemical Analysis and Sensing Techniques
- Material Properties and Applications
N.N. Krasovskii Institute of Mathematics and Mechanics of the Ural Branch of the Russian Academy of Sciences
2016-2024
Kazan Federal University
2007-2024
Sechenov University
2021
Lomonosov Moscow State University
2020
LIGO Scientific Collaboration
2019
Radar (United States)
2019
Marine Hydrophysical Institute
2018
Engelhardt Institute of Molecular Biology
2001-2013
Weatherford College
2010
German Institute of Human Nutrition
2004-2007
The prohibitin (PHB)-domain proteins are membrane that regulate a variety of biological activities, including mechanosensation, osmotic homeostasis, and cell signaling, although the mechanism this regulation is unknown. We have studied two members large protein family, MEC-2, which needed for touch sensitivity in Caenorhabditis elegans, Podocin, involved function filtration barrier mammalian kidney, find both bind cholesterol. This binding requires PHB domain (including palmitoylation sites...
Olfactory receptors are the largest group of orphan G protein-coupled with an infinitely small number agonists identified out thousands odorants. The de-orphaning olfactory receptor (OR) is complicated by its combinatorial odorant coding and thus requires large scale screening establishing receptor-specific profiles. Here, we report on stable reconstitution OR-specific signaling in HeLa/Olf cells via protein alphaolf adenylyl cyclase type-III to Ca2+ influx-mediating cyclic nucleotide-gated...
The human genome harbors 5 remnant genes coding for vomeronasal type-1 receptors, compared with 187 of such receptors in mice. In rodents, are typically expressed the organ. They believed to be highly selective and sensitive pheromone detectors, as may inferred from one receptor, V1rb2, responding picomolar concentrations mouse 2-heptanone. Expression patterns, ligands, signal transduction have, however, remained largely obscure. Our aim was deorphan functionally characterize these putative...
Two series of new lipophilic phosphonoformate and phosphonoacetate derivatives AZT d4T were synthesized evaluated as anti-HIV agents. The efficacy some the compounds in cell cultures infected with HIV-1 was higher than that parent nucleosides only slightly correlated to their stability phosphate buffer human blood serum. phosphonates are most probably prodrug forms corresponding nucleosides.
Here, we present the new method of approximate conformal mapping unit disk to a one-connected domain with smooth boundary without auxiliary constructions and iterations. The function is Taylor polynomial. applicable elasticity problems solution.
A new method of approximate conformal mapping the unit disk onto a simply connected domain and an annulus doubly with smooth boundaries is presented. The based on integral equations solution which reduced to linear system does not require iterations. function has form Taylor or Laurent polynomial defined annulus, respectively. easily computable.
A series of new nucleoside 5′-triphosphate mimetics, 2, 3, 5, 6, 8–10, modified at the glycone and all three phosphate residues, have been synthesised studied. These compounds only bear enzymatically labile anhydride bond between α β phosphorus atoms. The preparative chemistry involved preparation phosphonic salts 30, 31 32 coupling these species to morpholidate 33. mechanism formation some intermediates 'en route' 27 28 is discussed. All target demonstrated high stability in human blood...
The main disadvantages of 3′-azido-3′-deoxythymidine (zidovudine, AZT), the most common anti-HIV drug, are toxicity and a short half-life in organism. introduction an <i>H</i>-phosphonate group into AZT 5′ position resulted significant improvement its therapeutic properties allowed new Nikavir (AZT H-phosphonate). In this work, we described derivatives, namely, 5′-aminocarbonylphosphonates. synthesized compounds displayed antiviral cell cultures infected with HIV-1 capacity to release active...
Carbocyclic α,γ-bis(nucleoside)-5,5'-triphosphonates and α,δ-bis(nucleoside)-5,5'-tetraphosphonates (Ap4A Gp4G) analogues were shown to be a new type of terminating substrate HIV reverse transcriptase. They effectively inhibited the DNA synthesis catalyzed by this enzyme in model cell-free systems, but their antiviral activity both Rat1 fibroblast cell culture bearing MLV transcriptase HIV-infected MT-4 cells was low. When liposome delivery system used, efficacy compounds under study increased.
Anti-HIV activity and cytotoxicity were tested for novel phosphonate derivatives of AZT, d4T ddA. For the most active was 2′,3′-Dideoxy-2′,3′-didehydrothymidine 5′-isopropylphosphite among AZT highest shown by 2′,3′-Dideoxy-3′-azidothymidine 5′-cyclohexylphosphite.
Some natural and glycon‐modified dNTPs with β,γ‐pyrophosphate substitution at the triphosphate residue were synthesized studied to evaluate effect of these modifications on substrate properties in DNA synthesis catalyzed by human placental polymerases α β, avian myeloblastosis virus reverse transcriptase, calf thymus terminal deoxynucleotidyl transferase. Reverse transcriptase proved be enzyme least specific such modifications; activity β,γ‐methylenediphosphonate substituted dTTP...
We propose a new method for constructing an approximate solution of the two-dimensional Laplace equation in arbitrary doubly connected domain with smooth boundaries Dirichlet boundary conditions. Using fact that problem is represented as sum Schwarz and logarithmic function, we reduce Schwartz to Fredholm integral respect value conjugate harmonic function. The its turn reduced solving linear system Fourier coefficients truncated expansion unknown coefficient component determined from...
The operation of active antenna in receiving and transmitting modes is discussed. design based on the use one-port resonant transistor amplifier with opened system. Resonant system realized microstrip patch antenna. assumes implementation simultaneously. switching between does not need to be implemented.
Despite the numerous drawbacks, 3-azido-3-deoxythymidine (AZT, Zidovudine, Retrovir) remains one of key drugs used in treatment and prevention HIV infection both monotherapy HAART. A strategy searching for new effective safe AZT agents among latent (depot) forms has yielded its first positive results. In particular, sodium salt 5-H-phosphonate (Nikavir, phosphazide) demonstrated clinical advantages over parent AZT: foremost, lower toxicity better tolerability. It can be effectively vertical...
Several new types of adenosine N 1 -oxide (ANO) derivatives including -alkoxy and 6 -alkyl as well the analogues with a trihydroxycyclopentane ring in place ribose residue were synthesized their antiviral properties evaluated Vero LLC-MK2 cell cultures infected vaccinia, mousepox, monkeypox, cowpox, different isolates smallpox viruses. The activity ANO its significantly depended on virus type cultures. Mousepox monkeypox viruses most sensitive to these compounds, while vaccinia cowpox...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel Acyclic Nucleotides and Nucleoside 5'-Triphosphates Imitating 2',3'-Dideoxy-2',3'-didehydro nucleotides: Synthesis Biological PropertiesElena A. Shirokova, Natalia B. Tarussova, Alexander V. Shipitsin, Dmitry G. Semizarov, KrayevskyCite this: J. Med. Chem. 1994, 37, 22, 3739–3748Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October...
In this paper we propose a new method for solving the 2D Laplace equation with Dirichlet boundary conditions in simply and doubly connected domains. Here, apply numerical algorithm based on truncated Fourier series reduce corresponding Fredholm integral to finite system of linear equations.