A5033894683- Mitochondrial Function and Pathology
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cardiovascular Function and Risk Factors
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cardiac Valve Diseases and Treatments
- Microtubule and mitosis dynamics
- Liver physiology and pathology
- RNA Research and Splicing
- Renal and related cancers
- Cardiac Fibrosis and Remodeling
- Peroxisome Proliferator-Activated Receptors
- Congenital heart defects research
Goethe University Frankfurt
2021-2023
Institute of Molecular Biology
2022
Medizinische Hochschule Hannover
2022
Cardiac endoreplication drives disease anabolic processes to support pathologic cardiac growth.
After myocardial infarction in the adult heart remaining, non-infarcted tissue adapts to compensate loss of functional tissue. This adaptation requires changes gene expression networks, which are mostly controlled by transcription regulating proteins. Long non-coding transcripts (lncRNAs) taking part fine-tuning such programs. We describe and characterize cardiomyocyte specific lncRNA Sweetheart RNA (Swhtr), an approximately 10 kb long transcript divergently expressed from cardiac core...
The contractile phenotype of smooth muscle cells (SMCs) is transcriptionally controlled by a complex the DNA-binding protein SRF and transcriptional co-activator MYOCD. pathways that activate expression Myocd SMC structural genes in mesenchymal progenitors are diverse, reflecting different intrinsic extrinsic signaling inputs. Taking ureter as model, we analyzed whether Notch signaling, pathway previously implicated vascular development, also affects visceral differentiation. We show mice...
ABSTRACT After myocardial infarction in the adult heart remaining, non-infarcted tissue adapts to compensate loss of functional tissue. This adaptation requires changes gene expression networks, which are mostly controlled by transcription regulating proteins. Long non-coding transcripts (lncRNAs) now recognized for taking part fine-tuning such programs. We identified and characterized cardiomyocyte specific lncRNA Sweetheart RNA ( Swhtr ), an approximately 10 kb long transcript divergently...