A5028537203- Health Systems, Economic Evaluations, Quality of Life
- Dementia and Cognitive Impairment Research
- Lipoproteins and Cardiovascular Health
- Meta-analysis and systematic reviews
- Pneumonia and Respiratory Infections
- Acute Ischemic Stroke Management
- Blood Pressure and Hypertension Studies
- Pharmacovigilance and Adverse Drug Reactions
- Respiratory viral infections research
- Cardiovascular Health and Disease Prevention
- Nutritional Studies and Diet
- Health Sciences Research and Education
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neurological Disorders and Treatments
- Diet and metabolism studies
- Emergency and Acute Care Studies
- COVID-19 Clinical Research Studies
- Cholinesterase and Neurodegenerative Diseases
- Biosimilars and Bioanalytical Methods
- Alzheimer's disease research and treatments
- Clinical practice guidelines implementation
- Peripheral Artery Disease Management
- Nutrition and Health in Aging
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disease Mechanisms and Treatments
MRC Epidemiology Unit
2009-2024
London School of Hygiene & Tropical Medicine
2015-2024
Centro Nacional de Epidemiología
2023
AXON Neuroscience (Cyprus)
2022
University of Oxford
1987-2018
British Heart Foundation
2018
Medical Research Council
2018
Cancer Research UK
2018
MRC Population Health Research Unit
2018
Imperial College London
2006-2014
OBJECTIVES--To determine whether fibrinogen and lipid concentrations are risk factors for ischaemic stroke. DESIGN--Case-control study with a population based comparison within the overall study. SETTING--Oxfordshire community stroke project neurology clinic. SUBJECTS--105 patients who had transient attack or minor 352 randomly chosen controls matched age sex from same general practitioners as incident cases. 52 were ineligible refused interview. 104 cases 241 gave blood samples analysis....
<b>Background:</b> The issue of when to start treatment in Parkinson's disease (PD) remains controversial. Some favour at diagnosis while others opt for a "wait and watch" policy. effect the latter policy on self reported health status people with PD is unknown. <b>Aims:</b> To record through longitudinal use validated specific questionnaire (PDQ-39) untreated patients multiple centres UK. compare who were left those offered during follow-up. <b>Methods:</b> A multicentre, prospective, "real...
We conducted three nested case-control studies to evaluate the risk of breast, colon, and prostate cancers developing in patients exposed thiazolidinediones (TZDs) compared with other anti-diabetic agents.Cancer cases were matched five controls by age, gender, calendar year, time database from a cohort 1 26 971 diabetic taking medication US Integrated Healthcare Information Services database. Five hundred thirteen breast cancer 2557 controls, 408 colon 2027 643 3176 controls. Exposure an...
Abstract Background The 7-valent pneumococcal conjugate vaccine (PCV7) was introduced in 2006 and the 13-valent (PCV13) 2010 UK. PCVs are active immunization for prevention of invasive disease, pneumonia acute otitis media (AOM) caused by Streptococcus pneumoniae children. aim this observational study to estimate incidence rates (IRs) AOM children ≤17 years from 2003 2019 England, before after introduction vaccines (PCVs). Methods episodes were identified using Read diagnosis codes aged...
Background . Routine vaccination against Streptococcus pneumoniae is recommended in Canada for infants, the elderly, and individuals with chronic comorbidity. National incidence burden of all-cause pneumococcal pneumonia (excluding Quebec) were assessed. Methods Incidence, length stay, case-fatality rates hospitalized determined 2004–2010 using ICD-10 discharge data from Canadian Institutes Health Information Discharge Abstract Database. Population-at-risk obtained Statistics census....
Abstract Background Pneumococcal disease is a leading cause of communicable morbidity and mortality globally. We aimed to estimate invasive pneumococcal (IPD), pneumonia (PP) all-cause (ACP) incidence rates (IRs) in children aged 0–17 years England from 2003 2019. Methods A retrospective study ≤17 old 2019 using the Clinical Practice Research Datalink (CPRD) Gold Hospital Episodes Statistics Admitted Patient Care (HES APC) databases. IPD episodes were identified hospital records APC). PP...
Uncertainty remains about the aetiological role of lipids in stroke. We reviewed epidemiology light new studies and have reinterpreted evidence. A statistical overview performed on ten prospective examining relationship between total cholesterol subsequent stroke produced a pooled relative risk 1.31 (95% confidence interval 1.11–1.54; p < 0.01) for subjects with levels (roughly) 220 mg/dl above, compared values below this level. Correction ''regression dilution'' due to measurement error...
Abstract Background Acute otitis media (AOM) remains a common infection in children despite the introduction of pneumococcal conjugate vaccines. This study estimated AOM incidence rates (IRs) over time < 16 years old Germany following PCV13 introduction. Methods episodes were identified InGef healthcare claims database from 2014–2019 aged years. Each episode was classified as either simple or recurrent. Recurrent defined 3 more within 6-month period; 4 12-month period with at least one...
We carried out a case-control study to determine whether von Willebrand factor (vWF) antigen (and VII and tissue plasminogen activator [tPA] antigens) are associated with ischemic stroke. Ninety-five patients transient attack or minor stroke recruited from the Oxfordshire Community Stroke Project one neurology clinic were compared 236 controls, group-matched for age sex, same general practitioners as incident cases. In crude analyses, concentrations of vWF significantly higher in cases than...