A5091617325- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Research and Splicing
- Pharmacological Effects of Natural Compounds
- Nicotinic Acetylcholine Receptors Study
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Nuclear Structure and Function
- Birth, Development, and Health
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Adipose Tissue and Metabolism
- Medicinal Plants and Bioactive Compounds
- Neurogenesis and neuroplasticity mechanisms
- Biotin and Related Studies
- Estrogen and related hormone effects
- Hormonal and reproductive studies
- Inflammasome and immune disorders
- Immune cells in cancer
- Genetics and Neurodevelopmental Disorders
- Sphingolipid Metabolism and Signaling
- Genetic Associations and Epidemiology
- Neuroscience and Neuropharmacology Research
- Vitamin D Research Studies
Osaka University
2020-2024
Protein Research Foundation
2020-2024
Cellular senescence, a state of irreversible cell-cycle arrest caused by variety cellular stresses, is critically involved in age-related tissue dysfunction various organs. However, the features cells central nervous system that undergo senescence and their role neural impairment are not well understood as yet. Here, through comprehensive investigations utilising single-cell transcriptome analysis mouse models, we show microglia, particularly white matter, brain spinal cord during ageing...
Abstract KPNA1 is a mediator of nucleocytoplasmic transport that abundantly expressed in the mammalian brain and regulates neuronal differentiation synaptic function. De novo mutations Kpna1 have been identified using genome-wide association studies humans with schizophrenia; however, it remains unclear how contributes to schizophrenia pathogenesis. Recent suggested complex combination genetic environmental factors are closely related psychiatric disorders. Here, we found subchronic...
Abstract Schizophrenia is a psychiatric disorder that affects around 1% of the population in widespread populations, with severe cases leading to long-term hospitalization and necessitation lifelong treatment. Recent studies on schizophrenia have highlighted involvement inflammatory immunoregulatory mechanisms onset symptoms, usage anti-inflammatory treatments are being tested against periods rapid psychosis. In central nervous system, microglia innate immune which activated response wide...
Abstract Nicotine, an addictive compound found in tobacco, functions as agonist of nicotinic acetylcholine receptors (nAChRs) the brain. Interestingly, nicotine has been reported to act a cognitive enhancer both human subjects and experimental animals. However, its effects animal studies have not always consistent, sex differences identified on several behaviors. Specifically, role that plays modulating discrimination learning flexibility rodents is still unclear. Here, we evaluated...
Importin α1/KPNA1 is a member of the α family widely present in mammalian brain and has been characterized as regulator neuronal differentiation, synaptic functionality, anxiety-like behavior. In humans, de novo mutation KPNA1 (human α5) gene linked with schizophrenia; however, precise roles disorder-related behaviors are still unknown. Moreover, recent studies have highlighted importance gene-environment interactions development psychiatric disorders, we investigated effects Kpna1 deletion...
Importin α3 (Gene: Kpna3, the ortholog of human α4) is a member importin α family and participates in nucleocytoplasmic transport by forming trimeric complexes between cargo proteins β1. Evidence from studies has indicated that single nucleotide polymorphisms (SNP) KPNA3 gene are associated with occurrence several psychiatric disorders accompanied abnormal reward-related behavior, including schizophrenia, major depression, substance addiction. However, precise roles controlling reward...
Importin α4, which is encoded by the Kpna4 gene, a well-characterized nuclear-cytoplasmic transport factor known to mediate of transcription factors including NF-κB. Here, we report that knock-out (KO) mice exhibit psychiatric disorder-related behavioral abnormalities such as anxiety-related behaviors, decreased social interaction, and sensorimotor gating deficits. Contrary previous study predicting attenuated NF-κB activity result deficiency, observed significant increase in expression...
Steroids that contain a 3-hydroxyl group (3-OH steroids) are widely distributed in nature. During analysis with ESI-MS, they easily become dehydrated while the protonated form, resulting production of several precursor ions and leading to low sensitivity detection. To address this analytical challenge, here, we developed method for quantitation 3-OH steroids by LC-MS/MS coupled post-column addition lithium (Li) mobile phase. The Li ion has high affinity keto steroids, stabilizing their...
Abstract Rationale Clozapine N-oxide (CNO) has been developed as a ligand to selectively activate designer receptors exclusively activated by drugs (DREADDs). However, previous studies have revealed that peripherally injected CNO is reverse-metabolized into clozapine, which, in addition activating DREADDs, acts an antagonist at various neurotransmitter receptors, suggesting potential off-target effects of on animal physiology and behaviors. Recently, second-generation DREADD agonists...
ABSTRACT Importin α4, which is encoded by the Kpna4 gene, a well characterized nuclear-cytoplasmic transport factor known to mediate of transcription factors including NF-κB. Here, we report that knock-out (KO) mice exhibit psychiatric disorder-related behavioral abnormalities such as anxiety-related behaviors, deceased social interaction and sensorimotor gating deficits. Contrary previous study predicting attenuated NF-κB activity result deficiency, observed significant increase in...
1 Abstract Nicotine, an addictive compound found in tobacco, functions as agonist of nicotinic acetylcholine receptors (nAChRs) the brain. Interestingly, nicotine has been reported to act a cognitive enhancer both human subjects and experimental animals. However, its effects animal studies have not always consistent, sex differences identified on several behaviors. Specifically, role that plays modulating discrimination learning flexibility rodents is still unclear. Here, we evaluated...