A5040699202- Nicotinic Acetylcholine Receptors Study
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- RNA Research and Splicing
- Neurotransmitter Receptor Influence on Behavior
- Nuclear Structure and Function
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Biotin and Related Studies
- Inflammasome and immune disorders
Protein Research Foundation
2022-2024
Osaka University
2022-2024
Japan Society for the Promotion of Science
2024
Abstract Nicotine, an addictive compound found in tobacco, functions as agonist of nicotinic acetylcholine receptors (nAChRs) the brain. Interestingly, nicotine has been reported to act a cognitive enhancer both human subjects and experimental animals. However, its effects animal studies have not always consistent, sex differences identified on several behaviors. Specifically, role that plays modulating discrimination learning flexibility rodents is still unclear. Here, we evaluated...
Importin α3 (Gene: Kpna3, the ortholog of human α4) is a member importin α family and participates in nucleocytoplasmic transport by forming trimeric complexes between cargo proteins β1. Evidence from studies has indicated that single nucleotide polymorphisms (SNP) KPNA3 gene are associated with occurrence several psychiatric disorders accompanied abnormal reward-related behavior, including schizophrenia, major depression, substance addiction. However, precise roles controlling reward...
Importin α4, which is encoded by the Kpna4 gene, a well-characterized nuclear-cytoplasmic transport factor known to mediate of transcription factors including NF-κB. Here, we report that knock-out (KO) mice exhibit psychiatric disorder-related behavioral abnormalities such as anxiety-related behaviors, decreased social interaction, and sensorimotor gating deficits. Contrary previous study predicting attenuated NF-κB activity result deficiency, observed significant increase in expression...
Abstract Rationale Clozapine N-oxide (CNO) has been developed as a ligand to selectively activate designer receptors exclusively activated by drugs (DREADDs). However, previous studies have revealed that peripherally injected CNO is reverse-metabolized into clozapine, which, in addition activating DREADDs, acts an antagonist at various neurotransmitter receptors, suggesting potential off-target effects of on animal physiology and behaviors. Recently, second-generation DREADD agonists...
1 Abstract Nicotine, an addictive compound found in tobacco, functions as agonist of nicotinic acetylcholine receptors (nAChRs) the brain. Interestingly, nicotine has been reported to act a cognitive enhancer both human subjects and experimental animals. However, its effects animal studies have not always consistent, sex differences identified on several behaviors. Specifically, role that plays modulating discrimination learning flexibility rodents is still unclear. Here, we evaluated...
ABSTRACT Importin α4, which is encoded by the Kpna4 gene, a well characterized nuclear-cytoplasmic transport factor known to mediate of transcription factors including NF-κB. Here, we report that knock-out (KO) mice exhibit psychiatric disorder-related behavioral abnormalities such as anxiety-related behaviors, deceased social interaction and sensorimotor gating deficits. Contrary previous study predicting attenuated NF-κB activity result deficiency, observed significant increase in...