A5056980494- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Dementia and Cognitive Impairment Research
- Bone and Joint Diseases
- Functional Brain Connectivity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell Image Analysis Techniques
- Neuroscience and Neuropharmacology Research
- Genomics and Chromatin Dynamics
- Gene Regulatory Network Analysis
- Radiomics and Machine Learning in Medical Imaging
- Pluripotent Stem Cells Research
- Congenital heart defects research
- Advanced NMR Techniques and Applications
- Epigenetics and DNA Methylation
- Neurological Disease Mechanisms and Treatments
- Bioinformatics and Genomic Networks
University at Buffalo, State University of New York
2017-2024
Medical University of South Carolina
2020-2024
Abstract Studies of induced pluripotent stem cells (iPSCs) from schizophrenia patients and control individuals revealed that the disorder is programmed at preneuronal stage, involves a common dysregulated mRNA transcriptome, identified Integrative Nuclear FGFR1 Signaling mechanism. We used human embryonic cell (hESC) iPSC-derived cerebral organoids four controls three to model first trimester in utero brain development. The an abnormal scattering proliferating Ki67+ neural progenitor (NPCs)...
PyDesigner is a Python-based software package based on the original Diffusion parameter EStImation with Gibbs and NoisE Removal (DESIGNER) pipeline (Dv1) for dMRI preprocessing tensor estimation. This openly provided non-commercial research may not be used clinical care. combines tools from FSL MRtrix3 to perform denoising, ringing correction, eddy current motion brain masking, image smoothing, Rician bias correction optimize estimation of multiple diffusion measures. It can across platforms...
Objective The Alzheimer's continuum is biologically defined by beta‐amyloid deposition, which at the earliest stages superimposed upon white matter degeneration in aging. However, extent to these co‐occurring changes characterized relatively underexplored. goal of this study was use diffusional kurtosis imaging (DKI) and biophysical modeling detect describe amyloid‐related preclinical Alzheimer disease. Methods Cognitively unimpaired participants ages 45 85 years completed brain magnetic...
The 3×Tg‐AD mouse is one of the most studied animal models Alzheimer's disease (AD), and develops both amyloid beta deposits neurofibrillary tangles in a temporal spatial pattern that similar to human AD pathology. Additionally, abnormal myelination patterns with changes oligodendrocyte myelin marker expression are reported be an early pathological feature this model. Only few diffusion MRI (dMRI) studies have investigated white matter abnormalities mice, inconsistent results. Thus, goal...
ABSTRACT PyDesigner is an open-source and containerized Python software package, adapted from the DESIGNER pipeline, for diffusion weighted magnetic resonance imaging preprocessing tensor estimation. combines tools FSL MRtrix3 to reduce effects of signal noise artifacts on multiple measures that can be derived kurtosis tensors. This publication describes main features highlights its ease use across platforms, while examining accuracy robustness in deriving commonly used metrics.
Age-related white matter degeneration is characterized by myelin breakdown and neuronal fiber loss that preferentially occur in regions myelinate later development. Conventional diffusion MRI (dMRI) has demonstrated age-related increases diffusivity but provide limited information regarding the tissue-specific changes driving these effects. A recently developed dMRI biophysical modeling technique, Fiber Ball White Matter (FBWM) modeling, offers enhanced biological interpretability estimating...
Two distinct types of microscopic diffusion anisotropy (MA) are compared in brain for both normal control and transgenic (3xTg-AD) mice, which develop Alzheimer's disease pathology. The first type MA is the commonly used fractional (μFA), second a new measure referred to as μFA'. These two parameters have different symmetry properties that central their physical interpretations. Specifically, μFA invariant with respect local rotations compartmental tensors while μFA' global tensor...
PyDesigner is a Python-based software package based on the original Diffusion parameter EStImation with Gibbs and NoisE Removal (DESIGNER) pipeline (Dv1) for dMRI preprocessing tensor estimation. This openly provided non-commercial research may not be used clinical care. combines tools from FSL MRtrix3 to perform denoising, ringing correction, eddy current motion brain masking, image smoothing, Rician bias correction optimize estimation of multiple diffusion measures. It can across platforms...
As human progenitor cells differentiate into neurons, the activities of many genes change; these changes are maintained within a narrow range, referred to as genome homeostasis. This process, which alters synchronization entire expressed genome, is distorted in neurodevelopmental diseases such schizophrenia. The coordinated gene activity networks formed by altering sets comprise recurring coordination modules, governed entropy-controlling action nuclear FGFR1, known be associated with DNA...
Abstract Background The Alzheimer’s Continuum is biologically defined by beta‐amyloid deposition, encompassing individuals with or without other biomarker clinical changes (Jack et al., 2018). Beta‐amyloid deposition superimposed upon white matter degeneration in aging, but the degree to which these co‐occurring are characterized vivo preclinical stage less understood. goal of this study was use Diffusional Kurtosis Imaging (Jensen & Helpern, 2010) and biophysical modeling (Fieremans...
Neurodegenerative diseases including Alzheimer's affect millions around the world, and this number is projected to increase over years unless a breakthrough made. There are several theories on pathogenesis of neurodegenerative diseases, with amyloid cascade tau theory being most prominent ones. The formation plaques tangles collapses capillaries in brain, thereby inducing hypoxia destruction neurons from loss nourishment. While we do understand some changes that occur brain's vasculature...