A5004334813- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Hyperthermia Applications
- Nanopore and Nanochannel Transport Studies
- Ultrasound Imaging and Elastography
- RNA Interference and Gene Delivery
- Lipid Membrane Structure and Behavior
California Institute of Technology
2020-2024
ABSTRACT Targeted gene delivery to the brain is a critical tool for neuroscience research and has significant potential treat human disease. However, site-specific of common vectors such as adeno-associated viruses (AAVs) typically performed via invasive injections, limiting their scope clinical applications. Alternatively, focused ultrasound blood-brain-barrier opening (FUS-BBBO), noninvasively, enables entry AAVs into from systemic circulation. when used in conjunction with natural AAV...
The rapid growth, invasiveness, and resistance to treatment of glioblastoma multiforme (GBM) underscore the urgent need for improved diagnostics therapies. Current surgical practice is limited by challenges with intraoperative imaging, while recurrence monitoring requires expensive magnetic resonance or nuclear imaging scans. Here we introduce 'acoustic tumor paint', an approach labeling brain tumors ultrasound a widely accessible modality. We show that gas vesicles (GVs), natural air filled...