A5087684518- Diabetes Treatment and Management
- Peptidase Inhibition and Analysis
- Neuropeptides and Animal Physiology
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Sirtuins and Resveratrol in Medicine
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Enzyme Production and Characterization
- Catalysis and Hydrodesulfurization Studies
- Speech and Audio Processing
- Cancer Research and Treatments
- Speech Recognition and Synthesis
- Immune cells in cancer
- Electrocatalysts for Energy Conversion
- Circular RNAs in diseases
- Birth, Development, and Health
- Metabolomics and Mass Spectrometry Studies
- Adipokines, Inflammation, and Metabolic Diseases
- ATP Synthase and ATPases Research
- Enzyme Catalysis and Immobilization
- Catalytic Processes in Materials Science
Anhui Medical University
2017-2021
Chengdu University
2018
Ministry of Education of the People's Republic of China
2017
Anhui University
2017
Nankai University
2013-2016
Wenzhou Medical University
2015
Primary liver cancer (PLC) is one of the most common types worldwide. Hepatocellular carcinoma (HCC) accounts for approximately 90% PLC cases. The HCC microenvironment plays an important role in occurrence and development HCC. Immunotherapy has become effective treatment strategy. T lymphocytes are part microenvironment, programmed cell death 1 (PD-1) cytotoxic lymphocyte-associated antigen 4 (CTLA-4) main immunosuppressive molecules lymphocytes. Transforming growth factor β1 (TGF-β1) can...
Abstract Androgen receptor (AR) can suppress hepatocellular carcinoma (HCC) invasion and metastasis at an advanced stage. Vasculogenic mimicry (VM), a new vascularization pattern by which tumour tissues nourish themselves, is correlated with progression metastasis. Here, we investigated the effect of AR on formation VM its mechanism in HCC. The results suggested that could down‐regulate circular RNA (circRNA) 7 , up‐regulate micro (miRNA) 7‐5p HCC Small hairpin circR7 (ShcircR7) reverse...
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that decreases postprandial glycemic excursions by enhancing insulin secretion but with short half-life due to rapid inactivation enzymatic N-terminal truncation. Therefore, efforts are being made improve the stability of GLP-1 via modifying its structure or inhibiting dipeptidylpeptidase IV (DPP IV), which responsible for degradation. GLP-M, consisting 10 tandem repeated rolGLP-1 (GLP-1 analog), has been expressed in Pichia pastoris our...
Although hydrogen sulfide (H2S) was always a negative factor leading to the reduction of permeability palladium (Pd) membranes, its proper application could result in positive effect. In this study, pure Pd membranes were firstly reacted with H2S at 23–450 °C, and then treated by redox reactions. Afterwards, tested under different reaction conditions using penetrant testing device. Moreover, both products morphology changes occurred on membrane surface analyzed XRD, XPS SEM. The results...
Glucagon-like peptide-1 (GLP-1) is a short peptide that can significantly reduce blood glucose level. Recombination oral long-acting glucagon-like (rolGLP-1), GLP-1 analog generated from site-specific mutation of GLP-1. CTB non-toxic portion the cholera toxin and an ideal protein antigen carrier. In this study, we firstly constructed vector pET-22b (+)-CTB-10×rolGLP-1 to express fusion composed ten tandem repeated rolGLP-1 in BL21 (DE3) line E.coli. The CTB-10×rolGLP-1 was expressed...
Probiotics, i.e., bacteria expressing therapeutic peptides (protein), are used as a new type of orally administrated biologic drugs to treat diseases. To develop yeast strains which could effectively prevent and 2 diabetes mellitus, we firstly constructed the integrating plasmid pNK1-PGK successfully express green fluorescent protein (GFP) in Saccharomyces cerevisiae. The gene encoding ten tandem repeats glucagon-like peptide-1(10 × GLP-1) was cloned into vector resulting plasmids were then...
The traditional double-threshold endpoint detection method has the phenomenon of missing detection. Therefore, speech recognition (SR) system based on vector quantization (VQ) in this paper proposes an improved algorithm for phenomenon, which effectively avoids problem Then, Mel Frequency Cepstral Coefficients (MFCC) is used to extract characteristic parameters signal, and multistage quantify parameters. Experimental results show that, proposed improves rate text-independent speaker by 8.7%,...
Adiposis is reputed as a twin disease of type 2 diabetes and greatly harmful to human health. In order understand the molecular mechanisms adiposis, changes physiological, pathological, epigenetic correlative gene expression were investigated during adiposis development C57BL/6J mice induced by long time (9 months) high-fat high-sucrose diet (HFSD) sustainably. The results showed that mRNA transcription level Leptin, Glut4 Glut2 genes have been obviously changed, which exhibit negative...
Glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) play a similar but complementary role in the regulation of glucose levels islet β-cells. This study was aimed to develop fusion peptide, which combines 4 tandem repeated GLP-1 GIP (4rolGG), investigate its therapeutic effect on type 2 diabetes using diabetic mice model.A 4rolGG expression plasmid constructed expressed BL21 (DE3). By inducting with IPTG, at high level, confirmed by SDS-PAGE electrophoresis Western...