A5073662016- Genetics and Neurodevelopmental Disorders
- Genomic variations and chromosomal abnormalities
- DNA Repair Mechanisms
- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Genomics and Rare Diseases
- Tumors and Oncological Cases
- Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Effects of Radiation Exposure
- Medical Imaging and Pathology Studies
- Childhood Cancer Survivors' Quality of Life
- Radiation Dose and Imaging
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Salivary Gland Tumors Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Thyroid Cancer Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Social and Behavioral Studies
- Radiation Effects and Dosimetry
- Advanced Radiotherapy Techniques
German Cancer Research Center
2010-2018
Heidelberg University
2010-2018
Cancer Genetics (United States)
2013
Leipzig University
1985
Relapse with drug-resistant disease is the main cause of death in MYCN-amplified neuroblastoma patients. cells vitro are characterized by a failure to arrest at G(1)-S checkpoint after irradiation- or drug-induced DNA damage. We show that several cell lines harbor additional chromosomal aberrations targeting p53 and/or pRB pathway components, including CDK4/CCND1/MDM2 amplifications, p16INK4A/p14ARF deletions TP53 mutations. Cells these undergo significantly lower levels doxorubicin...
Common fragile sites (cFS) represent chromosomal regions that are prone to breakage after partial inhibition of DNA synthesis. Activation cFS is associated with various forms instability in cancer cells, and thought be an initiating event the generation damage early-stage tumorigenesis. Only a few have been fully characterized despite growing interest genomes. In this study, six-color fluorescence situ hybridization revealed FRA2C consists two spanning 747 kb FRA2Ctel 746 FRA2Ccen at 2p24.3...
The TP53 tumor suppressor pathway is abrogated by mutations in the majority of human cancers. Increased levels wild-type aggressive neuroblastomas appear paradox but are tolerated cells due to co-activation ubiquitin ligase, MDM2. role MDM2 antagonist, p14(ARF), controlling TP53-MDM2 balance neuroblastoma unresolved. In present study, we show that conditional p14(ARF) expression substantially suppresses viability, clonogenicity and anchorage-independent growth p14(ARF)-deficient or...
Common fragile sites (cFSs) represent parts of the normal chromosome structure susceptible to breakage under replication stress. Although only a small number cFSs have been molecularly characterized, genomic damage cFS genes appears be critical for development various human diseases. In this study, we fine mapped location FRA14B and showed that region spans 765 kb at 14q23.3, containing large gephyrin ( GPHN ) gene. The sequence is enriched in perfect A/T >24 stretches R‐loop forming...