Aims: This study aims to investigate the results of lack melatonin in cerebellar tissue pinealectomized Wistar albino rats using immunohistochemistry and biochemistry. Methods: Control, pinealectomy, sham pinealectomy groups were designed for experiment (n=8). Pinealectomy surgery employed. At end 30 days, cerebellum was used histopathological, glial fibrillary acidic protein (GFAP) immunostaining, biochemical (oxidative stress markers) analyses. Purkinje cell counts layer thickness also...

In chronic hepatitis B virus (HBV) infection, inflammation-associated cytokines including proinflammatory are involved in the development and progression of liver fibrosis. The is a source many that may influence function. High-mobility group box 1 (HMGB1) was identified as an inflammatory cytokine. HMGB1 present nuclei all mammalian cells released both through active secretion from various by passive release necrotic cells. Here we explore relationship between plasma levels serum levels,...

Licorice originates from the root of Glycyrrhiza glabra, which has a herbal ingredient, glycyrrhizic acid, and mineralocorticoid-like effect. Chronic intake licorice induces syndrome similar to that found in primary hyperaldosteronism. Excessive may cause hypermineralocorticoidism-like characterized by sodium water retention, hypertension, hypokalemia, metabolic alkalosis, low-renin activity, hypoaldosteronism. In this case report, an association edema, thrombocytopenia is developed due...

The aim of this study was to evaluate the impact intracerebroventricular chronic fibroblast growth factor 21 (FGF21) infusion on hypothalamic–pituitary–thyroid (HPT) axis, energy metabolism, food intake and body weight. Thirty male Wistar albino rats were used divided into three groups including control, sham (vehicle) FGF21 infused (n = 10). Intracerebroventricularly, vehicle for 7 days with (0.72 µg/day) artificial cerebrospinal fluid, respectively. During experimental period, changes in...

AIM: To determine whether there was a relationship between the neutrophil/lymphocyte (NLR), monocyte/ /lymphocyte (MLR), and platelet/lymphocyte ratios (PLR) measured in blood samples taken at admission clinical outcomes (CO) on 90th day patients, who were diagnosed as acute ischemic stroke (AIS) emergency department (ED) underwent mechanical thrombectomy (MT).METHOD: Patients aged ≥ 18 years, AIS ED MT included study.Patients, received diagnostic codes of "Cerebrovascular Diseases" (CVD)...

The need for colonoscopy is common among diabetic patients. However, there are no standards per se bowel preparation in patients with type 2 diabetes. In this study, we evaluated the efficacy, safety, and tolerability of sodium phosphate (NaP), quality cleansing relation to glycemic control late complications.A total 50 consecutive non-diabetic underwent by NaP. Fasting blood glucose, (Na), potassium (K), calcium (Ca), phosphorus (P), magnesium, creatinine levels were measured on procedure...

We aimed to evaluate whether there was a relationship between endocan (human endothelial cell-specific molecule-1) levels and disease prognosis in patients who presented the emergency department with coronavirus 2019 (COVID-19). A total of 60 COVID-19 were hospitalized from clinical wards control group consisting healthy adult individuals (n = 28), included study. The majority (93.3%) discharged after recovery; 6.7% died. median value 243.5 ng/mL patient versus 201.5 (P .002). level 240.5...

We aimed to evaluate and compare the efficacy safety of high-dose furosemide+salt orally by comparing HSS+ furosemide (i.v.) repeated paracentesis in patients with RA.This was a prospective study 78 cirrhotic RA, randomized into three groups: Group A (n= 25) i.v. (200-300 mg bid) 3% hypotonic saline solution (HSS) (once or twice day); B 26) oral tablets (360-520 salt (2.5 g bid); and, C 27) large-volume-paracentesis (RLVP) albumin infusion. Patients without hyperkalemia were administrated...

The present study aimed to analyze the effects of pinealectomy and crocin treatment in isoproterenol-induced myocardial damage. Seventy rats were divided into seven groups: control, sham (PNX), isoproterenol (ISO; 85 mg/kg on 29th 30th days experiment, subcutaneous injection), PNX + ISO, (50 mg/kg/day for 30 days, intragastric administration), ISO crocin. procedure was performed first day study. A significant increase observed serum cardiac damage markers (CK-MB, Troponin I) after...

Alzheimer's disease (AD) is a progressive neurodegenerative disease. This study was performed to determine the possible relationship between melatonin, which known play role in neuro-protective mechanism AD, and fasciculation elongation protein zeta 1 (FEZ1). Thirty male rats were included separated into 3 groups (n = 10) as vehicle (artificial cerebrospinal fluid), streptozotocin (STZ) STZ+melatonin (MLT). Two intracerebroventricular (icv) injections of mg/kg STZ made 48 hours apart. MLT...

Carbon monoxide (CO) is one of the most common causes unintentional poisonings resulting in death. Patients with more severe findings such as loss consciousness and persistent neurological or cardiovascular dysfunction require hospitalization. Although there are clinical which determine hospitalization criteria patients presenting CO poisoning, some ambiguity regarding laboratory biomarkers length hospital stay (LOS) these patients. In this study, we aimed to identify effectiveness initial...

We aimed to observe the possible effects of melatonin (MLT) deprivation (pinealectomy) and exogenous MLT administration on pulmonary edema induced by alpha-naphthylthiourea (ANTU), a toxic chemical agent, in rats. Seventy animals were assigned seven groups: control, sham pinealectomy (PINX), PINX, ANTU (10 mg/kg intraperitoneal day 30), + mg/kg/day i.p. for 30 days), PINX MLT.In this study, pleural effusion (PE) formation, lung weight/body weight (LW/BW) PE/BW ratios (fluid accumulation...

Objective: This study aimed to assess the relationship between Type 2 Diabetes Mellitus (DM) and its complica­tions with severity of depression. Methods: Eighty diabetics under age 65 using insulin were enrolled clinical biochemical data recorded. The neuropathy was deter­mined by “United Kingdom screening score” (UKNS) whereas depression determined “Beck scale” (BDS). Ne­phropathy retinopathy assessed micro­albumin-creatinine ratio in spot urine samples de­tailed examination retina an...

Amaç: Bisfenoller (BP'ler), genel popülasyonun yaygın olarak kullandığı birçok üründe bulunan potansiyel hormon bozuculardır. Bisfenol A (BPA) ise, vücudun metabolik sistemleri üzerindeki olumsuz etkilerine rağmen, bazı plastik ve reçinelerin üretiminde uzun yıllardır kullanılan endüstriyel bir kimyasaldır. BPA gibi toksik ajanlardan dolayısıyla çevresel kirleticilerden etkilenen en önemli organlardan biri böbreklerdir. Ellajik asit (EA) fitokimyasal polifenol bileşiğidir yapılan çalışmada...