A5049849832- Nanoplatforms for cancer theranostics
- Analytical Chemistry and Sensors
- Molecular Sensors and Ion Detection
- Supramolecular Self-Assembly in Materials
- Advanced biosensing and bioanalysis techniques
- Force Microscopy Techniques and Applications
- Nonlinear Dynamics and Pattern Formation
- Molecular Junctions and Nanostructures
- Biosensors and Analytical Detection
- Analytical Chemistry and Chromatography
- Nanocluster Synthesis and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Porphyrin and Phthalocyanine Chemistry
- Advanced Nanomaterials in Catalysis
- Electrochemical sensors and biosensors
- Nanoparticle-Based Drug Delivery
- Conducting polymers and applications
- Mass Spectrometry Techniques and Applications
- Luminescence and Fluorescent Materials
- Electrochemical Analysis and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Ionic liquids properties and applications
- Advanced Proteomics Techniques and Applications
- Liquid Crystal Research Advancements
Louisiana State University
2012-2018
Louisiana State University Agricultural Center
2014
Chemotherapeutic agents with low toxicity to normal tissues are a major goal in cancer research. In this regard, the therapeutic activities of cationic dyes, such as rhodamine 6G, toward cells have been studied for decades observed toxicities and cells. Herein, we report 6G-based organic salts varying counteranions that stable under physiological conditions, display excellent fluorescence photostability, more importantly tunable chemotherapeutic properties. Our vitro studies indicate...
We report on the synthesis and characterization of a PEGylated IR786 GUMBOS (Group Uniform Materials Based Organic Salts). The this material was accomplished using three step protocol: (1) substitution chloride cyclohexenyl ring in heptamethine chain by 6-aminohexanoic acid, (2) grafting methoxy polyethylene glycol (MeOPEG) onto acid via an esterification reaction, (3) anion exchange between [PEG786][I] lithium bis(trifluoromethylsulfonyl)imide (LiNTf2) or sodium...
A novel pH sensitive, colorimetric ionic liquid nanosensor based on phosphonium salts of fluorescein is reported. Herein, various stoichiometries were synthesized by use a trihexyltetradecylphosphonium cation [TTP]+ in combination with dianionic [FL]2− and monoanionic [FL]− fluorescein. Nanomaterials derived from these two compounds yielded contrasting responses neutral acidic environments. Variations fluorescence spectra as function also observed. Examination TEM DLS data revealed...
A rapid liquid phase extraction employing a novel hydrophobic surfactant-based room temperature ionic (RTIL), tetrabutylphosphonium dioctyl sulfosuccinate ([4C4 P][AOT]), coupled with capillary electrophoretic-UV (CE-UV) detection is developed for removal and determination of phenolic compounds. The long-carbon-chain RTIL used sparingly soluble in most solvents can be to replace volatile organic solvents. This fact, combination functional-surfactant-anions, proposed reduce the interfacial...
Herein, we report on the role of endocytosis in selective chemotherpeutic toxicity rhodamine 6G (R6G) based nanomaterials, i.e., nanoGUMBOS, that are derived from a group uniform materials organic salts (GUMBOS). Evaluation cellular uptake presence and absence inhibitors suggests nanoGUMBOS internalization via clathrin-mediated cancer cells reveals lack endocytic normal cells. Results characterization these nanomaterials suggest leads to dissociation within endosomal environment. This...
Detection of hydrophobic peptides remains a major obstacle for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). This stems from the fact that most matrices MALDI are hydrophilic and therefore have low affinities peptides. Herein, 1-aminopyrene (AP) AP-derived group uniform materials based on organic salts (GUMBOS) as novel MALDI-MS analyses were investigated peptides.A number solid-phase AP-based GUMBOS synthesized with variable hydrophobicity simply by changing...
We report on the synthesis and characterization of multifunctional ionic liquid crystals (melting points below 100 °C) which possess chirality fluorescent behavior as well mesomorphic magnetic properties. In this regard, (1R,2S)-(−)-N-methylephedrine ((−)MeEph), containing a chiral center, is linked with variable alkyl chain lengths (e.g., 14, 16, 18 carbons) to yield crystalline properties in cations these compounds. A complex counteranion consisting trivalent dysprosium (Dy3+) thiocyanate...
This study represents a one pot simplistic approach towards development of multimodal theranostic nanomaterials.