Non-alcoholic fatty liver disease (NAFLD) and -steatohepatitis (NASH) imply a state of excessive fat built-up in livers with/or without inflammation have led to serious medical concerns recent years. Antrodan (Ant), purified β-glucan from A. cinnamomea has been shown exhibit tremendous bioactivity, including hepatoprotective, antihyperlipidemic, antiliver cancer, anti-inflammatory effects. Considering the already well-known alleviating bioactivity for alcoholic steatohepatitis (ASH), we...

Supercritical fluid SF-CO2 treatment of Rosemarinus officinalis L. fresh leaves under optimum conditions (80 degrees C at 5,000 psi) yielded 5.3% extract supercritical extraction (SFE)-80, in which five major active principles were identified by liquid chromatography/mass spectrometry (LC/MS), viz., rosmarinic acid, carnosol, 12-methoxycarnosic carnosic and methyl carnosate. Total phenolic content was 155.8 mg/ gallic acid equivalent (GAE)/g SFE-80, showed 1,1-diphenyl-2-picrylhydrazyl...

Nutrient levels in buckwheats that were maximized day 8 sprouts (D8SP) included total phenolics, quercetin, and 𝓁-ascorbic acid, whereas those of oxalic, malic, tartaric, citric acids, rutin, γ-aminobutyric acid (GABA) found to reach maximum on 10. Ethanolic extract D8SP (2.5 mg/mL) revealed potent free-radical scavenging (FRS) antioxidative (ANO) capabilities. However, its Fe2+-chelating capability was only moderate. To further study the hypolipidemic activity D8SP, 36 Syrian hamsters...

Finger citron [Citrus medica L. var. Sarcodactylis Hort, Rutaceae] (FC) fruits, widely cultivated in Japan, the southern provinces of China and Taiwan, are commonly used as functional vegetables preserved sweetmeats. Previously we identified major compounds essential oils (% EO) FC fruits to be d-limonene (51.24), gamma-terpenene (33.71), alpha-pinene (3.40), beta-pinene (2.88). Documented evidence on its insulin secretion characteristics is still lacking. In parallel compositional analysis,...

A composite nano-TiO2-chitosan with collagen artificial skin (NTCAS) showed promising characteristics of moderate water absorptivity (110 wt.-%), fine thickness (0.34 mm), low density (0.33 mg x mm(-3)), biodegradability (<3.0%), and favorable time-dependent (0.0521 mL(-1) h(-1) on Day 0; 0.0006 h(-1)on 3 post covering). More importantly, it uniquely potent bactericidal (sterilization) property relatively large values pseudo first-order kinetic coefficients (0.1736-0.0360 min(-1)) for TiO2...

Astaxanthine (ASTx) is a novel carotenoid nutraceutical occurring in many crustaceans and red yeasts. It has potent antioxidant, photoprotective, hepatodetoxicant, anti-inflammatory activities. Documented effect of ASTx on treatment neurodegenerative disease still lacking. We used the β-amyloid peptide (Aβ) 25–35-treated PC12 model to investigate neuron-protective ASTx. The parameters examined included cell viability, caspase activation, various apoptotic biomarkers that play their critical...

Lipopolysaccharide (LPS)-induced acute hepatotoxicity is significantly associated with oxidative stress. Astaxanthin (AST), a xanthophyll carotenoid, well known for its potent antioxidant capacity. However, drawbacks of poor aqueous solubility and low bioavailability have limited utility. Liposome encapsulation considered as an effective alternative use the improvement hydrophobic compound. We hypothesized that AST encapsulated within liposomes (LA) apparently shows improved stability...

Operando imaging techniques have become increasingly valuable in both battery research and manufacturing. However, the reliability of these methods can be compromised by instabilities setup operando cells, particularly when utilizing high-resolution systems. The acquired data often include features arising from undesirable system vibrations drift, as well scientifically relevant deformations occurring sample during cell operation. For meaningful analysis, it is crucial to distinguish...

Five polysaccharide fractions (AB-1, AB-2, AB-3, AB-4, and AB-5) were obtained after a systemic solvent extraction precipitation of Agaricus blazei mycelia with yields 5.20, 9.03, 2.84, 17.47, 0.44%, respectively. Among which, AB-1 AB-3 demonstrated great DPPH• radical scavenging ability around 85.0 72.0%, respectively, at concentration 5 mg/mL. The ferrous ion chelating powers even more excellent 1 mg/mL, reaching almost over 99.65% for AB-4 as compared to the reference control citric acid...

Abstract: The aqueous extract of Psidium guajava L. (PE) inhibited the cancer cell DU-145 in a dose- and time-dependent manner. At 1.0 mg/mL, PE reduced viability PCa (the androgen independent cells) to 36.1 3.59%, respectively after 48 h 72 incubations. absolute suppressing capability (VSC)AC could reach 262.5 cells-mL-h/mg on exposure for h, corresponding safe ranges, i.e. percent rates (PVSR) 2.72 2.41 folds comparing PZ-HPV-7 cells when treated with at 0.5 mg/mL h. In addition, colony...

Isolation of phenolic diterpene constituents from the freeze-dried leaves Rosmarinus officinalis has been obtained by supercritical extraction with carbon dioxide. To determine ideal conditions for maximum yield extract, nine different using three levels pressures (3000, 4000 and 5000 psi) in combination temperatures at 40, 60 80 degrees C, respectively, analyses corresponding antioxidant activities which existed extracts investigated. The activity each extract was determined...

The unusual hypolipidemic activity of the methanolic fractionate essential oil (EOM) obtained from mountain celery seed was previously reported. most enriched 9(Z)-octadecenamide (oleamide) speculated to be responsible for relevant bioactivity. Chemically syntheized oleamide (CSO) yielded 85.1% with a purity 98.6% when identified by RP-HPLC, FTIR, HREIMS, (1)H NMR, and (13)C NMR. CSO tested its antioxidative bioactivities. Results indicated potently regard serum TG, TC, LDL-C, LDL-C/HDL-C,...

Background The renal function of chronic kidney disease (CKD) patients may be improved by a number rehabilitative mechanisms. Swimming exercise training was supposed to beneficial its recovery. Methodology/Principal Findings Doxorubicin-induced CKD (DRCKD) rat model performed. programmed three days per week, 30 or 60 min day for total period 11 weeks. Serum biochemical and pathological parameters were examined. In DRCKD, hyperlipidemia observed. Active mesangial cell activation evidenced...

Ferulic acid (4-hydroxy-3-methoxycinnamic acid) (FA) is a ubiquitous health beneficial phenolic acid. Although FA has shown diversity of biological activities including anti-inflammatory, antihypercholesterolemic and anticancer bioactivities, studies revealing its adverse effects are accumulating. Recently, 3D-cultures to exhibit uniquely behaviors different from that 2D cultures. To understand whether the cytotoxicity against T24 cell line (a bladder cancer line) in 2D-culture could...

Rhizoma <italic>A. officinarum</italic> (Hance) Farw, synonymously is called rhizoma galangae or smaller galangal (hereafter abbreviated as AO).

Trauma to intracochlear structures during cochlear implant insertion is associated with poorer hearing outcomes. One way surgeons can influence trauma by choosing the surgical approach. We seek compare cochleostomy (CO), peri-round window (PRW), and round (RW) approaches using a fresh frozen temporal bone model.Experiments bones.Cochlear insertions three aforementioned were performed on 15 human bones Cochlear 422 electrode. Insertions evaluated examining fluoroscopic recordings of...

Preservation of residual low-frequency hearing has become a priority in cochlear implantation. The purpose this study was to compare rates preservation and effects on performance loss acoustic with two different length electrodes.

Aqueous extract of Psidium guajava L. budding leaves (PE) has been shown to possess anti-prostate cancer activity in a cell line model. We examined whether its bioactivity could be conserved either the presence or absence synthetic androgen R1881. In both cases, PE was inhibit LNCaP proliferation and down-regulate expressions receptor (AR) prostate specific antigen (PSA). The cytotoxicity by enhanced LDH release cells. flow cytometry analysis revealed cycle arrests at G(0)/G(1) phase with...

Dictyophora indusiata (Vent. ex Pers.) Fish Phallaceae (Chinese name Zhu-Sūn, the bamboo fungi) has been used as a medicinal mushroom to treat many inflammatory, gastric and neural diseases since 618 AD in China. We hypothesize that soluble polysaccharides (SP) present D. their monosaccharide profiles can act an important role affecting antioxidative capability, which turn would influence biological activity involving anti-inflammatory, immune enhancing anticancer. obtained six SP fractions...

Many phytoantioxidants have therapeutic drawbacks due to their potent prooxidant bioactivity. It is hypothesized that (PAO) are beneficial only the early-stage diabetes mellitus (DM) and will become ineffective once renopathy occurs. Gallic acid, rutin, EGCG, ferulic acid (FA), quercetin were tried on streptozotocin (STZ)-induced DM rat model for a 28 week experimental period. All of these PAO shown be hypoglycemic action. The incidence cataract (50%), injured glomerules, renal cell...