There are several reports of Ct values RT PCR assays for COVID 19 being associated with disease severity and infectivity. We studied the correlation between mortality at our hospital . All patients diagnosed illness admitted study site whom were available included in study. The mild had significantly lower than severe but also been tested earlier those disease. who died survived here again they shorter duration symptoms before testing. therefore recommend that time testing since onset should...

Healthcare worker (HCW) infections due to COVID-19 are of serious consequence. Testing for antibodies against in HCWs has been previously recommended. We conducted a serosurvey at private hospital Mumbai which is treating COVID patients. A total 244 were tested. The prevalence infection asymptomatic was 4.3% and symptomatic untested 70%. recommend that with previous history symptoms who not tested/tested negative by reverse transcription–polymerase chain reaction should be tested least 2...

Background: There is a need to generate accurate data on temporal trends in incidence rates, aetiology and antimicrobial susceptibility of central line-associated bloodstream infections (CLABSIs) the Indian setting. Aim: To study incidence, CLABSI adult, paediatric neonatal intensive care units (NICUs) tertiary private hospital Mumbai, India. Materials Methods:This prospective observational conducted at NICUs from 2011 2018. was defined as per Centers for Disease Control criteria....

Clostridium difficile infection (CDI) is a serious healthcare-associated (HAI) now being increasingly reported from hospitals across India. However, there paucity of data on the incidence and impact control measures CDI in India.This retrospective study conducted at tertiary care hospital Mumbai January 2016 to December 2017. All patients with healthcare-onset diarrhoea were tested for C. by glutamate dehydrogenase (GDH)/toxin assay or nucleic acid amplification test (NAAT). was defined as...

Probiotic lactic acid bacteria (LAB) have been engrossed in plentiful food fermentations, known to man for millennia. The current investigation was aimed at investigating technical attributes, such as production of bioactive peptides, particularly ACE-I activity (anti-hypertensive property), proteolytic activity, and antioxidant activities the potential probiotic LAB strains isolated from a diverse dairy non-dairy based fermented foods. Among all ten isolates, PFC21, sauerkraut, exhibited...

Background: This study aims to the incidence, microbial aetiology and antimicrobial susceptibility of surgical site infections (SSIs) at a private tertiary care hospital in Mumbai, India, compare it with previously published data from same institute as well literature. Methods: is prospective observational done over 6 years (January 2013–December 2018) 750-bed multi-specialty among all patients undergoing clean clean-contaminated surgeries. Standard guidelines for preventing, diagnosing...

Abstract Introduction The growing resistance pattern of the gram-positive pathogens along with a steady increase in minimum inhibitory concentration currently available antibiotics have led to an morbidity and mortality rates India. This study aims access shifting antibiotic susceptibility paradigm various infections at tertiary care center. Methods is 3-year retrospective observational which was performed from January 2016 December 2018 hospital Mumbai. All clinically significant cocci...

Bloodstream infections (BSIs) remain a leading cause of morbidity and mortality especially in intensive care units across the world timely appropriate antimicrobial therapy is corner stone its treatment (i) To compare time difference to diagnose BSIs between FABCID2 identification sensitivity by automated systems (ii) analyse clinical utility panel positive blood samples among ICU patients. This was prospective study done from July 2020 August where consecutive thirty culture received ICUs...

Bile tolerance, bile deconjugation and cholesterol reducing properties of five strains lactobacilli, viz. PD2, PC27, PSC6, PH5 PFC21 were tested with a view to select culture for conducting in vivo feeding trial hyperlipemic mice. Strain PD2 was found be most tolerant, followed by PH5, PSC6 PFC21. The strain released maximum amount free cholic acid (2.37 mM) from sodium taurocholate. With respect assimilation, showed reduction 76.85%. Overall two among gave good performance all these vitro...

Antimicrobial resistance has emerged as a major public health problem in India. Hence effective antimicrobial stewardship programs (AMSP) are needed. We report the design, implementation and results of prospective audit feedback based AMSP at private tertiary care hospital.During study period - January 2018 to December 2019 prescription restricted antimicrobials required filling justification form which was reviewed by committee (AMSC) 48-72 ​h. Patients whom stopped earlier than 48 ​h were...

Probiotics are the live microbial food/feed supplements which benefit host when administered in a certain number.Probiotics have been within our domestic use for as long people consumed fermented milk, curd, butter but their association with health benefits dates only from turn of last century, Metchnikoff drew attention to promoting effects some gut microflora on host, and suggested that ingestion milk products ameliorated this so called auto-intoxication.Species Lactobacillus,...

Probiotic potential of Lactobacillus rhamnosus PFC21 isolated from fermented cabbage (Sauerkraut) was evaluated through in vitro studies. A laboratory made sauerkraut isolate showed intense probiotic prospective and to be further deliberated for the beneficial application society. The culture exhibited excellent acid tolerance at pH 1 bile 0.8% sodium taurocholate, negligible reduction viable count against artificial gastric intestinal juice presence enzymes i.e. pepsin pancreatin 2 8...

64 years old male presented fever, gastrointestinal symptoms, COVID-19 infection with bioprosthetic mitral in situ, cardio embolic stroke 2 ago. The D ECHO showed a vegetation indicating infective endocarditis. Three paired blood cultures grew Kytococcus schroeteri. organism was sensitive to Vancomycin, Teicoplanin, Gentamycin and Linezolid. Patient had multiorgan dysfunction which further deteriorated into failure, disseminated intravascular coagulation resulting death of the patient.

Patients with lung cancer suffer frequent infections which not only thwart the effect of oncological treatment but also affect overall survival. We present a fatal case where coinfection Pneumocystis jirovecii and Lophomonas blattarum caused pneumonia in patient advanced treated metastatic adenocarcinoma lung. Cytomegalovirus (CMV) PCR was positive for patient. Newer pathogens are emerging there is an increase incidence coinfections. Pneumonia due to rare unusual requires high degree...

Burkholderia cepacia complex (BCC) is a well-recognized cause of nosocomial infections. We describe here young healthy male who presented with fever and chest pain ECG changes acute pericarditis. Two sets blood cultures at separate timings grew gram negative bacilli identified as BCC by molecular methods. The patient responded to intravenous ceftazidime despite high MIC's. source infection was probably contaminated nasal spray/nasal saline wash which he used after balloon sinoplasty...

Several tissue engineering approaches have been proposed for articular cartilage repair, but to date there is no consensus on the optimal method. Self-assembling microsphere-incorporated cell sheets developed recently applications, as they provide an environment chondrogenic induction of human mesenchymal stem cells (hMSCs). In current study, early repair was assessed in a rabbit osteochondral defect model treated with self-assembling hMSC incorporated bioactive polymer microspheres....

A 44 years old, immunocompetent, male patient was admitted to the hospital with fever and left hemiparesis. Patient had undergone decompressive craniotomy partial clot evacuation at another institute for right Prieto-occipital intracranial haemorrhage (ICH) subarachnoid (SAH) four weeks back. CT scan on day of admission, showed peripherally enhancing brain abscess in parietal lobe surrounding oedema which surgical site. Pus evacuated from grew . treated intravenous vancomycin two a...