A5079116746- Prenatal Screening and Diagnostics
- Pregnancy and preeclampsia studies
- MicroRNA in disease regulation
- Advancements in Transdermal Drug Delivery
- Plant Reproductive Biology
- Skin and Cellular Biology Research
- Cellular transport and secretion
- Skin Protection and Aging
- 3D Printing in Biomedical Research
- Contact Dermatitis and Allergies
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
Queen Mary University of London
2022-2024
The placenta is a fast-evolving organ with large morphological and histological differences across eutherians, but the genetic changes driving placental evolution have not been fully elucidated. Transposable elements, through their capacity to quickly generate variation affect host gene regulation, may helped define species-specific trophoblast expression programs. Here we assess contribution of transposable elements human as enhancers or promoters. Using epigenomic data from primary...
Junctional epidermolysis bullosa caused by loss-of-function variants in genes encoding the skin basement membrane proteins laminin 332, type XVII collagen, or integrin α6β4 affects patients from birth with severe blistering, eventually leading to scarring and early lethality. In this study, we have optimized a previously published junctional bullosa-knockout mouse model weekly tamoxifen intraperitoneal injections, resulting more controllable model. Owing titratable dosing, now recapitulates...
Abstract The placenta is a fast-evolving organ with large morphological and histological differences across eutherians, but the genetic changes driving placental evolution have not been fully elucidated. Transposable elements, through their capacity to quickly generate variation affect host gene regulation, may helped define species-specific trophoblast expression programmes. Here, we assessed contribution of transposable elements human as enhancers or promoters. Using epigenomic data from...
Abstract The placenta is a fast-evolving organ with large morphological and histological differences across eutherians, but the genetic changes driving placental evolution have not been fully elucidated. Transposable elements, through their capacity to quickly generate variation affect host gene regulation, may helped define species-specific trophoblast expression programmes. Here, we assessed contribution of transposable elements human as enhancers or promoters. Using epigenomic data from...
Abstract The skin provides an essential barrier to the body. As we age, make-up of this changes, with a reduction stratum corneum lipids. This loss lipids as age can lead formation dry and easily damaged skin, allowing for water from surface. One mechanism in is dysfunctional lipid transport. To investigate transport within have developed two-dimensional high-throughput cholesterol assay. Using assay screened 200 naturally occurring compounds 800 plant extracts determine their ability...
Abstract Individuals with Junctional Epidermolysis Bullosa (JEB), a rare genetic skin disease characterised by loss of function mutations in the Laminin332 (Lam332), do not survive beyond their first birthday. Here we report that Lam332 leads to absence cholesterol lipid from epidermis vitro and vivo . Stable knockdown chains (LAMA3, LAMB3 LAMC2) was established using shRNA were used develop 3D equivalents. Changes synthesis assessed western blot analysis immunohistochemistry. Findings...