A5064405939- Pregnancy and preeclampsia studies
- MicroRNA in disease regulation
- Prenatal Screening and Diagnostics
- Cancer-related gene regulation
- RNA Research and Splicing
- Genetic Syndromes and Imprinting
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- Congenital heart defects research
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
Queen Mary University of London
2022-2023
King's College London
2013-2021
Guy's Hospital
2020
The placenta is a fast-evolving organ with large morphological and histological differences across eutherians, but the genetic changes driving placental evolution have not been fully elucidated. Transposable elements, through their capacity to quickly generate variation affect host gene regulation, may helped define species-specific trophoblast expression programs. Here we assess contribution of transposable elements human as enhancers or promoters. Using epigenomic data from primary...
DNA binding factors are essential for regulating gene expression. CTCF and cohesin with central roles in chromatin organization We determined the sites of to mouse brain, genome wide an allele-specific manner high read-depth ChIP-seq. By comparing our results existing data liver embryonic stem (ES) cells, we investigated tissue specificity sites. ES cells have fewer unique occupied than consistent a ground-state pattern that is elaborated during differentiation. without canonical consensus...
Dopa decarboxylase (DDC) synthesizes serotonin in the developing mouse heart where it is encoded by Ddc_exon1a, a tissue-specific paternally expressed imprinted gene. Ddc_exon1a shares an imprinting control region (ICR) with imprinted, maternally (outside of central nervous system) Grb10 gene on chromosome 11, but little else known about expression Ddc_exon1a. Fluorescent immunostaining localizes DDC to myocardium pre-natal heart, susceptible abnormal development and implicated congenital...
Alternative splicing (AS) and alternative polyadenylation (APA) generate diverse transcripts in mammalian genomes during development differentiation. Epigenetic marks such as trimethylation of histone H3 lysine 36 (H3K36me3) DNA methylation play a role generating transcriptome diversity. Intragenic CpG islands (iCGIs) their corresponding host genes exhibit dynamic epigenetic gene expression patterns between different tissues. We hypothesise that iCGI-associated H3K36me3, transcription can...
Abstract The placenta is a fast-evolving organ with large morphological and histological differences across eutherians, but the genetic changes driving placental evolution have not been fully elucidated. Transposable elements, through their capacity to quickly generate variation affect host gene regulation, may helped define species-specific trophoblast expression programmes. Here, we assessed contribution of transposable elements human as enhancers or promoters. Using epigenomic data from...
Abstract The placenta is a fast-evolving organ with large morphological and histological differences across eutherians, but the genetic changes driving placental evolution have not been fully elucidated. Transposable elements, through their capacity to quickly generate variation affect host gene regulation, may helped define species-specific trophoblast expression programmes. Here, we assessed contribution of transposable elements human as enhancers or promoters. Using epigenomic data from...
ABSTRACT Alternative splicing (AS) and alternative polyadenylation (APA) generate diverse transcripts in mammalian genomes during development differentiation. Epigenetic factors such as trimethylation of histone H3 lysine 36 (H3K36me3) DNA methylation play a role generating transcriptome diversity. Intragenic CpG islands (iCGIs) their corresponding host genes exhibit dynamic epigenetic gene expression patterns between different tissues. We hypothesise that iCGI-associated H3K36me3,...