- Photoacoustic and Ultrasonic Imaging
- Optical Imaging and Spectroscopy Techniques
- Spectroscopy Techniques in Biomedical and Chemical Research
- Optical Coherence Tomography Applications
- Spectroscopy and Chemometric Analyses
- Thermography and Photoacoustic Techniques
- Photonic and Optical Devices
- Advanced Fiber Optic Sensors
- Skin Protection and Aging
- Cutaneous Melanoma Detection and Management
- Optical Polarization and Ellipsometry
- Advanced Fluorescence Microscopy Techniques
- Light effects on plants
- Biosensors and Analytical Detection
- Analytical Chemistry and Sensors
- Photonic Crystals and Applications
- Photosynthetic Processes and Mechanisms
- Advanced Fiber Laser Technologies
- Weed Control and Herbicide Applications
- Greenhouse Technology and Climate Control
- Metabolomics and Mass Spectrometry Studies
- Biocrusts and Microbial Ecology
- Semiconductor Lasers and Optical Devices
- Advanced Chemical Sensor Technologies
- Optical measurement and interference techniques
Laser Zentrum Hannover
2019-2024
Leibniz University of Applied Sciences
2023
Leibniz University Hannover
2011-2020
Hearing4all
2014-2019
Excellence Cluster Universe
2016
Abstract Contemporary white light-emitting diodes (LEDs) are much more efficient than compact fluorescent lamps and hence rapidly capturing the market for general illumination. LEDs also replacing halogen or even newer xenon based in automotive headlamps. Because laser inherently brighter often corresponding LEDs, there is great research interest developing diode illumination systems. Operating at higher current densities with smaller form factors, may outperform future. This article reviews...
In this work different fibre optic sensors for the structural health monitoring of civil engineering structures are reported. A crack sensor and two moisture have been designed to detect ingress in concrete based building structures. Moreover, degeneration mechanical properties optical glass hence their long-term stability reliability due chemical impact environment is discussed as well advantage applying a system sewerage tunnels demonstrated.
Autonomous robots in the agri-food sector are increasing yearly, promoting application of precision agriculture techniques. The same applies to online services and techniques implemented over Internet, such as Internet Things (IoT) cloud computing, which make big data, edge digital twins technologies possible. Developers autonomous vehicles understand that for must take advantage these on strengthen their usability. This integration can be achieved using different strategies, but existing...
Abstract Purpose Challenges in sustainable development envisioned the European Union for agricultural sector require innovation to raise efficiency of production and safety farming processes farmers ensure food consumers. One key productivity factors plant is effective weeding. The WeLASER project aimed develop a high-power autonomous vehicle with lasers control weeds. To be sustainable, invention should have high environmental performance whole life cycle perspective, including its...
In vivo Raman spectroscopy with low signal-to-noise ratio and strong, irregularly shaped fluorescence background imposes a challenge for automatic baseline correction methods. this work, an approach that enables fast efficient batch has been developed, which is based on morphological operation in combination mollifier algorithm. As algorithm relies only three parameters, are determined by the given experimental conditions, it can be used objective processing of many spectra. The...
A new multimodal system for rapid, noninvasive in vivo skin cancer screening is presented, combining optical coherence tomography (OCT) and optoacoustic (OA) modalities to provide precise tumor depth determination with a Raman spectroscopic modality capable of detecting the lesion type and, thus, providing diagnostic capability. Both OA setups use wide field illumination ensure compliance maximum permissible exposure (MPE) requirements. The signal collected via OCT scanning lens maximize...
A reliable, fast, and non‐invasive determination of melanoma thickness in vivo is highly desirable for clinical dermatology as it may facilitate the identification surgical margins, determine if a sentinel node biopsy should be performed or not, reduce number interventions patients. In this work, optical coherence tomography (OCT) high frequency ultrasound (HFUS) are evaluated quantitative preoperative assessment skin infiltration depth melanocytic tissue. Both methods allow imaging at...
Low-loss optical-coupling structures are highly relevant for applications in fields as diverse information and communication technologies, integrated circuits, or flexible highly-functional polymer sensor networks. For this suitable reliable production methods crucial. Self-written waveguides an interesting solution. In work, we present a simple efficient one-polymer approach self-written optical connections between light-guiding such single-mode multi-mode fibers that relies on self...
A combined optical coherence tomography (OCT)-Raman probe was designed and built into a spectral domain OCT head, its performance evaluated compared to the most common Raman setups, based on fiber bundle confocal free space optics. Due use of full field view an scanning lens, has superior within maximum permissible exposure limits, other two probes. Skin spectra, recorded in vivo, further prove feasibility OCT-Raman for future vivo clinical applications skin cancer screening.
Resonance Raman microspectroscopy in combination with hierarchical cluster analysis (HCA) is one of the most promising tools for rapid examination complex biological and medical samples. HCA a ready, computerized tool examining large sets data common characteristics, multitude algorithms this purpose have been developed over years. However, resonance spectra obtained from samples may originate different chromophores as well chromophore found host environments, i.e., bacteria. Therefore,...
Optoacoustic (OA) measurements can not only be used for imaging purposes but as a more general tool to "sense" physical characteristics of biological tissue, such geometric features and intrinsic optical properties. In order pave the way systematic model-guided analysis complex objects we devised numerical simulations in accordance with experimental measurements. We validate our computational approach results observed layered polyvinyl alcohol hydrogel samples, using melanin absorbing agent....
The temperature-sensitive gating of human Connexin 26 (hCx26) was analyzed with confocal Raman microscopy. High-resolution spectra covering the spectral range between 400 and 1500 rel. cm(-1) a resolution 1 were fully annotated, revealing notable differences spectrum recorded from solubilized hCx26 in Ca(2+)-buffered POPC at 10°C any other set protein conditions (temperature, Ca(2+) presence, presence). Spectral components originating specific amino acids show that TM1/EL1 parahelix probably...
In this study the application of UV-A-laser (343 nm) or UV-C (254 irradiation combined with a bacteriophage treatment was investigated to reduce Campylobacter jejuni on surface chicken breast fillet. At radiant exposure 26.2 J/cm2 inactivated 1.8 ± 0.1 log10 CFU/piece C. PT14, and 2.0 when phage C11 applied additionally multiplicity infection (MOI) 1. Using at J/cm2, an inactivation 0.5 PT14 achieved irradiating alone 1.0 MOI 100. Inactivation by either found be additive. The sequence...
Resonance Raman microscopy is well suited to examine living bacterial samples without further preparation. Therefore, comparatively little thought has been given its compatibility with common fixation methods. However, of cell a very important tool in the microbiological sciences, allowing preservation specific condition for examination, future measurements, transport, or later reference. We examined effects three fixatives-ethanol, formaldehyde solution, and gentle heat--on resonant...
Whispering gallery mode (WGM) resonators are versatile high sensitivity sensors, but applications regularly suffer from elaborate and expensive manufacturing read-out. We have realized a simple inexpensive concept for an all-polymer WGM sensor. Here, we evaluate its performance relative humidity measurements demonstrating of 47 pm/% RH. Our results show the sensor concepts’ promising potential use in real-life environments.
Dermatoscopes are routinely used in skin cancer screening but rarely employed for the diagnosis of other conditions. Broader application is promising from a diagnostic point view as biopsies differential may be avoided it requires non-contact devices allowing comparably large field that not commercially available today. Autofocus and color reproducibility specific challenges development dermatoscopy beyond screening. We present prototype such system including solutions autofocus independent...
Electrospun fiber scaffolds are gaining in importance the area of tissue engineering. They can be used, for example, to fabricate graded implants mimic tendon bone junction. For grading tensile strength scaffolds, orientation fibers plays a major role. This is currently measured by hand scanning electron microscope (SEM) images. In this work, correlation between polarimetric information generated measuring Mueller matrix (MM) and electrospun reported. this, MM which were manufactured with...
Absorption or resonance Raman scattering are often used to identify and even quantify carotenoids in situ. We studied the absorption spectra, spectra their behavior of β-carotene different molecular environments set up as mixtures from lipid (emulsion) non-polar (ethanol) solvents a polar component (water) with regard application references for situ measurement. show how both profiles strongly depend on environment. Most notably, our data suggests that characteristic bathochromic peak...
Dermoscopy systems that do not require direct skin contact open up the possibility to overcome limitations of established dermoscopes and promote application this diagnostic tool beyond cancer screening. In work, we present a non-contact remote digital dermoscope with large field view, high resolution true color imaging. We report preliminary clinical results for imaging melanocytic nevi two common inflammatory diseases, psoriasis lichen ruber planus, obtained in mode demonstrating potential...